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van Dommelen, P. (author), Barios, R.M. (author), Arnaud, L. (author), le Masne, Q. (author), Koledova, E. (author)Worldwide regulations during COVID-19 positively and negatively impacted self-management in paediatric patients with chronic medical conditions. We investigated the impact of regulations on adherence to recombinant human growth hormone (r-hGH) therapy in paediatric patients with growth disorders, using real-world adherence data extracted March...article 2023
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Bekdemir, C. (author), Doosje, E. (author), Seykens, X. (author)At present, the hydrogen combustion engine has gained renewed interest from the heavy-duty internal combustion engine (ICE) industry as an enabler for fast decarbonization of well-to-wheel emissions and reinforced by the vast commitment of key stakeholders to establish a green hydrogen infrastructure. Past studies have often focused on partial...conference paper 2022
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Assefi, A. (author), van Dommelen, P. (author), Arnaud, L. (author), Otero, C. (author), Fernandez-Luque, L. (author), Koledova, E. (author), Calliari, L.E. (author)Background: Recombinant human growth hormone (rhGH) therapy is an effective treatment for children with growth disorders. However, poor outcomes are often associated with suboptimal adherence to treatment. Objective: The easypod connected injection device records and transmits injection settings and dose data from patients receiving rhGH. In...article 2022
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Singh, A. (author), Fokker, P.A. (author)This work is an extension of the time-resolved poro-elasto-plastic MohrCoulomb model by Fokker et al to include a more realistic constitutive model. Experiments on Slochteren sandstone revealed that the inelastic deformation contributes significantly in compressive deformation almost in all stages of loading and instigated the development of a...article 2021
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Wassing, B.B.T. (author), Candela, T.G.G. (author), Osinga, S. (author), Peters, E. (author), Buijze, L. (author), Fokker, P.A. (author), van Wees, J.D.A.M. (author)This paper describes and deploys a workflow to assess the evolution of seismicity associated to injection of cold fluids close to a fault. We employ a coupled numerical thermo-hydro-mechanical simulator to simulate the evolution of pressures, temperatures and stress on the fault. Adopting rate-and-state seismicity theory we assess induced...article 2021
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Bosklopper, J. (author), Sapra, H. (author), van de Ketterij, R. (author), van Sluijs, W. (author), Bekdemir, C. (author), de Vos, P. (author), Visser, K. (author)The maritime sector is currently facing a serious challenge of reducing emissions to meet the strict international and national emission regulations. In response to this challenge, the industry is initiating several research initiatives focused towards employment of alternative fuels in marine internal combustion engines. One of the promising...conference paper 2020
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Lathouwers, S. (author), Everts, M.H. (author), Huisman, M. (author)String sanitizers are widely used functions for preventing injection attacks such as SQL injections and cross-site scripting (XSS). It is therefore crucial that the implementations of such string sanitizers are correct. We present a novel approach to reason about a sanitizer's correctness by automatically generating a model of the implementation...conference paper 2020
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Bijlsma, T. (author), Buriachevskyi, A. (author), Frigerio, A. (author), Fu, Y. (author), Goossens, K. (author), Ors, A.O. (author), Van Der Perk, P.J. (author), Terechko, A. (author), Vermeulen, B. (author)Autonomous vehicles use cyber-physical systems to provide comfort and safety to passengers. Design of safety mechanisms for such systems is hindered by the growing quantity and complexity of SoCs (System-on-a-Chip) and software stacks required for autonomous operation. Our study tackles two challenges: (1) fault handling in an autonomous driving...conference paper 2020
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Seykens, X. (author), Bekdemir, C. (author), Han, J. (author), Willems, R. (author), van Hal, J. (author)This paper focusses on the application of bioalcohols (ethanol and butanol) derived from seaweed in Heavy-Duty (HD) Compression Ignition (CI) combustion engines. Seaweed-based fuels do not claim land and are not in competition with the food chain. Currently, the application of high octane bioalcohols is limited to Spark Ignition (SI) engines....conference paper 2020
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Koledova, E. (author), Tornincasa, V. (author), van Dommelen, P. (author)Background. Poor adherence to long-term recombinant human growth hormone (r-hGH) treatment can lead to suboptimal clinical outcomes; consequently, supporting and monitoring adherence is a crucial part of patient management. We assessed adherence to r-hGH treatment in children with growth disorders over 48 months using a connected monitoring...article 2020
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van Beek, P.J.G. (author), González Díez, N. (author), Aardal, P. (author)Flexible corrugated pipes as used for the transport of gas in offshore deepwater applications can generate undesired flow-induced pulsations (FLIP). This phenomenon has been also traditionally called “singing risers”. The pulsations generated may result in high-amplitude cyclic stresses in the pipe systems attached to the flexible. Moreover, an...conference paper 2020
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Fu, Y. (author), Terechko, A. (author), Bijlsma, T. (author), Cuijners, P.J.L. (author), Redegeld, J. (author), Ors, A.O. (author)Autonomous vehicles use Electronic Control Units running complex software to improve passenger comfort and safety. To test safety of in-vehicle electronics, the ISO 26262 standard on functional safety recommends using fault injection during component and system-level design. A Fault Injection Framework (FIF) induces hard-to-trigger hardware and...conference paper 2019
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Willems, F. (author), Kupper, F. (author), Ramesh, S. (author), Indrajuana, A. (author), Doosje, E. (author)Reactivity Controlled Compression Ignition (RCCI) combines very high thermal efficiencies with ultra-low engine out NO x and PM emissions. Moreover, it enables the use of a wide range of fuels. As this pre-mixed combustion concept relies on controlled auto-ignition, closed-loop combustion control is essential to guarantee safe and stable...conference paper 2019
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Simone, G. (author), Dyson, M.J. (author), Weijtens, C.H.L. (author), Meskers, S.C.J. (author), Coehoorn, R. (author), Janssen, R.A.J. (author), Gelinck, G.H. (author)Minimizing the reverse bias dark current while retaining external quantum efficiency is crucial if the light detection sensitivity of organic photodiodes (OPDs) is to compete with inorganic photodetectors. However, a quantitative relationship between the magnitude of the dark current density under reverse bias (Jd) and the properties of the bulk...article 2019
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Hunicz, J. (author), Mikulski, M. (author)Low-temperature combustion in reciprocating engines appears to be a cutting-edge technology which ensures extremely low emissions of nitrogen oxides and particulate matters in parallel with high fuel efficiency. This mode of combustion can be realized in homogeneous charge compression ignition engines. However, this technology poses challenges,...article 2018
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Hunicz, J. (author), Mikulski, M. (author), Rybak, A. (author)Controlled auto-ignition (CAI) is an advanced combustion technology offering high thermal efficiency and low NOX emissions. One promising approach to achieve CAI combustion is application of negative valve overlap resulting in internal exhaust gas re-circulation. However, combustion control is still an issue which should be resolved before wide...conference paper 2018
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Hunicz, J. (author), Mikulski, M. (author)One of the pending issues regarding Homogeneous Charge Compression Ignition (HCCI) engines is high load operation limit constrained by excessive pressure rise rates (PRRs). The present study investigates various measures to reduce combustion harness in a residual-affected HCCI engine. At the same time, the impact of those measures on efficiency...conference paper 2018
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Hunicz, J. (author), Mikulski, M. (author), Geca, M.S. (author), Kordos, P. (author), Komsta, H. (author)Homogeneous charge compression ignition concepts despite high efficiency and ultra-low nitrous oxides emissions, suffer from week controllability and load range limited by excessive pressure rise rates. In the present work, controlled auto-ignition is achieved via direct injection of gasoline into the exhaust gasses recompressed during negative...article 2018
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Duda, K. (author), Wierzbicki, S. (author), Śmieja, M. (author), Mikulski, M. (author)In the present paper, laboratory produced, animal origin biofuels (swine lard and turkey lard had been used as raw material for biofuel production) were evaluated in terms of physicochemical parameters and compared with commercial mineral diesel fuel and its mixture with rapeseed oil methyl esters. Basing on the results of physicochemical...article 2018
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van Hees, R.P.J. (author), Lubelli, B.A. (author), Hacuebord, A. (author)The injection of chemical products, meant to penetrate in the capillaries of the materials composingan affected wall, is perhaps the most diffused method to deal with rising damp. The majority of thesechemical products are hydrophobic treatments; they can be either solvent-based or (increasingly) water-based. Traditionally, these products are...article 2018