Searched for: subject%3A%22infiltration%22
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Bodin, J. (author), Kocbach Bølling, A. (author), Wendt, A. (author), Eliasson, L. (author), Becher, R. (author), Kuper, F. (author), Løvik, M. (author), Nygaard, U.C. (author)
Type 1 diabetes mellitus (T1DM) is an autoimmune destruction of insulin producing pancreatic beta-cells due to a genetic predisposition and can be triggered by environmental factors. We have previously shown that bisphenol A (BPA) accelerates the spontaneous development of diabetes in non-obese diabetic (NOD) mice. Here, we hypothesized that...
article 2015
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Sutanudjaja, E.H. (author), van Beek, L.P.H. (author), de Jong, S.M. (author), van Geer, F.C. (author), Bierkens, M.F.P. (author)
We explore the possibility of using remotely sensed soil moisture data and in situ discharge observations to calibrate a large-extent hydrological model. The model used is PCR-GLOBWB-MOD, which is a physically based and fully coupled groundwater-land surface model operating at a daily basis and having a resolution of 30 arc sec (about 1 km at...
article 2014
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Jacobs, P. (author), Phaff, J.C. (author), Voogt, M.H. (author)
An intervention study with a decentral electrostatic filter has been carried out in a nursery. The field study shows that it is possible to reach a reduction up to 80% of ultra-fine (<0.1 μm) and up to 68% for the PM1 and PM2,5-PM1 fractions at a relatively low energy consumption. These particle fractions were mostly determined by the outdoor...
conference paper 2014
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de Lange-Brokaar, B.J.E. (author), Ioan-Facsinay, A. (author), van Osch, G.J.V.M. (author), Zuurmond, A.-M. (author), Schoones, J. (author), Toes, R.E.M. (author), Huizinga, T.W.J. (author), Kloppenburg, M. (author)
Objective: Although osteoarthritis (OA) is considered a non-inflammatory condition, it is widely accepted that synovial inflammation is a feature of OA. However, the role of immune cells and their cytokines in OA is largely unknown. This narrative systematic review summarizes the knowledge of inflammatory properties, immune cells and their...
article 2012
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Mariman, R. (author), Kremer, S.H.A. (author), van Erk, M. (author), Lagerweij, T. (author), Koning, F. (author), Nagelkerken, L. (author)
Background: Host-microbiota interactions in the intestinal mucosa play a major role in intestinal immune homeostasis and control the threshold of local inflammation. The aim of this study was to evaluate the efficacy of probiotics in the recurrent trinitrobenzene sulfonic acid (TNBS)-induced colitis model and gain more insight into protective...
article 2012
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van Gaans, P.F.M. (author), Griffioen, J. (author), Mol, G. (author), Klaver, G. (author)
Purpose: Sedimentary aquifers are prone to anthropogenic disturbance. Measures aimed at mitigation or adaptation require sound information on the reactivity of soil/sediments towards the infiltrating water, as this determines the chemical quality of the groundwater and receiving surface waters. Here, we address the issues of relevant sediment...
article 2011
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de Louw, P.G.B. (author), Eeman, S. (author), Siemon, B. (author), Voortman, B.R. (author), Gunnink, J. (author), van Baaren, E.S. (author), Oude Essink, G.H.P. (author)
In deltaic areas with saline seepage, fresh water availability is often limited to shallow rainwater lenses lying on top of saline groundwater. Here we describe the characteristics and spatial variability of such lenses in areas with saline seepage and the mechanisms that control their occurrence and size. Our findings are based on different...
article 2011
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Balguid, A. (author), Mol, A. (author), van Marion, M.H. (author), Bank, R.A. (author), Bouten, C.V.C. (author), Baaijens, F.P.T. (author), TNO Kwaliteit van Leven (author)
Despite the attractive features of nanofibrous scaffolds for cell attachment in tissue-engineering (TE) applications, impeded cell ingrowth has been reported in electrospun scaffolds. Previous findings have shown that the scaffold can function as a sieve, keeping cells on the scaffold surface, and that cell migration into the scaffold does not...
article 2009
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Abdul-Hussien, H. (author), Hanemaaijer, R. (author), Verheijen, J.H. (author), van Bockel, J.H. (author), Geelkerken, R.H. (author), Lindeman, J.H.N. (author), TNO Kwaliteit van Leven (author)
Background: Matrix metalloproteinase-9 (MMP-9) is thought to play a central role in abdominal aortic aneurysm (AAA) initiation. Doxycycline, a tetracycline analogue, has direct MMP-9-inhibiting properties in vitro, and it effectively suppresses AAA development in rodents. Observed inhibition of AAA progression, and contradictory findings in...
article 2009
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Kupreishvili, K. (author), ter Weeme, M. (author), Morré, S.A. (author), van den Brule, A.J.C. (author), Huybregts, M.A.J.M. (author), Quax, P.H.A. (author), ten Velden, J. (author), van Hinsbergh, V.W.M. (author), Stooker, W. (author), Eijsman, L. (author), Niessen, H.W.M. (author), TNO Kwaliteit van Leven (author)
Background: Several studies have suggested an association between Chlamydophila pneumoniae (Cp) infection and atherosclerosis. A recent study detected Cp DNA in the saphenous vein of 12% of all patients before bypass grafting and in 38% of failed grafts. We used a system in which human veins were perfused with autologous blood under arterial...
article 2008
document
Arts, J.H.E. (author), Schijf, M.A. (author), Kuper, C.F. (author), TNO Kwaliteit van Leven (author)
Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, the effect of airway irritation by synthetic amorphous silica (SAS) on respiratory allergy to trimellitic anhydride (TMA) was studied. Brown Norway (BN) rats were topically sensitized on day 0 and on day 7,...
article 2008
document
van den Brink, C. (author), Zaadnoordijk, W.J. (author), van der Grift, B. (author), de Ruiter, P.C. (author), Griffioen, J. (author), TNO Bouw en Ondergrond (author)
A negotiation support system (NSS) was developed to solve groundwater conflicts that arose during land-use management. It was set up in cooperation with the stakeholders involved to provide information on the impact of land use, e.g., agriculture, nature (forested areas), recreation, and urban areas, on the quality of both infiltrating and...
article 2008
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Kel, J.M. (author), de Geus, E.D. (author), van Stipdonk, M.J. (author), Drijfhout, J.W. (author), Koning, F. (author), Nagelkerken, L. (author), TNO Kwaliteit van Leven (author)
In this study, we investigated the development of T cell responses in mice after administration of a mannosylated ovalbumin peptide (M-OVA323-339). Immunization with M-OVA323-339 in complete adjuvant resulted in enhanced antigen presentation in draining lymph nodes. Monitoring the fate of CFSE-labeled ovalbumin peptide-specific TCR transgenic...
article 2008
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Zhu, Q. (author), de With, G. (author), Dortmans, L.J.M.G. (author), Feenstra, F. (author), TNO Industrie (author)
Near net-shape fabrication of hydroxyapatite (HA) glass composites has been attempted by infiltrating a glass into porous HA performs. Main efforts were put to develop glasses that are chemically compatible with HA at elevated temperatures. After extensive investigations in the phosphate and borosilicate systems, glasses of (50-55)SiO2-(20-25...
article 2004
document
Nagelkerken, L. (author), Haspels, I. (author), van Rijs, W. (author), Blauw, B. (author), Ferrant, J.L. (author), Hess, D.M. (author), Garber, E.A. (author), Taylor, F.R. (author), Burkly, L.C. (author), Gaubius Instituut TNO (author)
It has been demonstrated that anti-CD154 mAb treatment effectively inhibits the development of experimental autoimmune encephalomyelitis (EAE). However, although it appears to prevent the induction of Th1 cells and reactivation of encephalitogenic T cells within the CNS, little information is available regarding the involvement of alternative...
article 2004
document
Wipfler, E.L. (author), van Dijke, M.I.J. (author), van der Zee, S.E.A.T.M. (author)
We considered dense nonaqueous phase liquid (DNAPL) infiltration into a water-unsaturated porous medium that consists of two horizontal layers, of which the top layer has a lower intrinsic permeability than the bottom layer. DNAPL is the intermediate-wetting fluid with respect to the wetting water and the nonwetting air. The layer interface...
article 2004
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Bouw, L. (author), Oude Essink, G.H.P. (author)
A basin-scale hydrogeological study of the inverted northern Broad Fourteens Basin, Netherlands offshore, has resulted in a reconstruction of geological evolution, an estimate of Late Cretaceous topography and model scenarios of syn-inversion meteoric water infiltration. This study was performed in the scope of a basin-scale analysis of the...
article 2003
document
Griffioen, J. (author)
Fertilization of agricultural land in groundwater infiltration areas often causes deterioration of groundwater quality. In addition to nitrogen and phosphorous, potassium deserves attention. The fate of potassium in the subsurface is controlled mainly by cation-exchange. Use of the Potassium Adsorption Ratio (PAR), analogous to the Sodium...
article 2001
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TNO Prins Maurits Laboratorium, Department of Pharmacology (author), Langeveld-Wildschut, E.G. (author), Bruijnzeel, P.L.B. (author), Mudde, G.C. (author), Versluis, C. (author), van Dijk-van Ieperen, A.G. (author), Bihari, I.C. (author), Knol, E.F. (author), Thepen, T. (author), Bruijnzeel-Koomen, C.A.F.M. (author), van Reijsen, F.C. (author)
article 2000
document
Energieonderzoek Centrum Nederland (author), Koene, F.G.H. (author), Ligthart, F.A.T.M. (author)
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report 2000
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