Searched for: subject%3A%22heart%255C%2Binfarction%22
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Kühnast, S. (author), Fiocco, M. (author), van der Hoorn, J.W.A. (author), Princen, H.M.G. (author), Jukema, J.W. (author)
Non-HDL-cholesterol is well recognised as a primary causal risk factor in cardiovascular disease. However, despite consistent epidemiological evidence for an inverse association between HDL-C and coronary heart disease, clinical trials aimed at raising HDL-C (AIM-HIGH, HPS2-THRIVE, dal-OUTCOMES) failed to meet their primary goals. This...
article 2015
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van den Borne, S.W.M. (author), Cleutjens, J.P.M. (author), Hanemaaijer, R. (author), Creemers, E.E. (author), Smits, J.F.M. (author), Daemen, M.J.A.P. (author), Blankesteijn, W.M. (author), TNO Kwaliteit van Leven (author)
Background: Infarct rupture is a usually fatal complication of myocardial infarction (MI), for which no molecular mechanism has been described in humans. Experimental evidence in mouse models suggests that the degradation of the extracellular matrix by matrix metalloproteinases (MMPs) plays an important role in infarct rupture. The present study...
article 2009
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van der Hoeven, B.L. (author), Pires, N.M.M. (author), Warda, H.M. (author), Putter, H. (author), Quax, P.H.A. (author), Schalij, M.J. (author), Jukema, J.W. (author), TNO Kwaliteit van Leven (author)
Diabetes mellitus (DM) is a strong predictor of in-stent restenosis. This may be due to a higher level of vascular inflammation. We hypothesized that diabetic patients will benefit from dexamethasone-eluting stents, since local inflammation and consequently neointimal growth are suppressed and no systemic side effects will occur. Methods: 21...
article 2008
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Monraats, P.S. (author), Kurreeman, F.A.S. (author), Pons, D. (author), Sewgobind, V.D.K.D. (author), de Vries, F.R. (author), Zwinderman, A.H. (author), de Maat, M.P.M. (author), Doevendans, P.A. (author), de Winter, R.J. (author), Tio, R.A. (author), Waltenberger, J. (author), Huizinga, T.W.J. (author), Eefting, D. (author), Quax, P.H.A. (author), Frants, R.R. (author), van der Laarse, A. (author), van der Wall, E.E. (author), Jukema, J.W. (author), TNO Kwaliteit van Leven (author)
Genetic factors appear to be important in the process of restenosis after percutaneous coronary intervention (PCI), as well as in inflammation, a pivotal factor in restenosis. An important mediator in the inflammatory response is interleukin (IL)-10. Our aim was to study whether genetic variants in IL-10 predispose to the risk of restenosis. The...
article 2007
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Beulens, J.W.J. (author), Rimm, E.B. (author), Ascherio, A. (author), Spiegelman, D. (author), Hendriks, H.F.J. (author), Mukamal, K.J. (author), TNO Kwaliteit van Leven (author)
Background: Heavy alcohol consumption increases risk for hypertension, which is in itself a strong risk factor for cardiovascular disease (CVD). However, data on the association between alcohol consumption and CVD among individuals with hypertension are scarce. Objective: To assess whether alcohol consumption is inversely associated with CVD...
article 2007
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Zacharowski, K. (author), Zacharowski, P.A. (author), Friedl, P. (author), Mastan, P. (author), Koch, A. (author), Boehm, O. (author), Rother, R.P. (author), Reingruber, S. (author), Henning, R. (author), Emeis, J.J. (author), Petzelbauer, P. (author), TNO Kwaliteit van Leven (author)
Many compounds have been shown to prevent reperfusion injury in various animal models, although to date, translation into clinic has revealed several obstacles. Therefore, the National Heart, Lung, and Blood Institute convened a working group to discuss reasons for such failure. As a result, the concept of adequately powered, blinded, randomized...
article 2007
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Beulens, J.W.J. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
article 2006
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Wykretowicz, A. (author), Guzik, P. (author), Bartkowiak, G. (author), Krauze, T. (author), Kasinowski, R. (author), Dziarmaga, M. (author), Wesseling, K.H. (author), Wysocki, H. (author), TNO Biomedical Instrumentation (author)
Endothelial dysfunction and reduced BRS (baroreflex sensitivity) may be present in patients with CAD (coronary artery disease). The normal fasting glucose level does not exclude abnormal glucose metabolism in patients with CAD. The aim of present study was to evaluate endothelial function and BRS according to glucose metabolism in patients with...
article 2005
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Agema, W.R.P. (author), de Maat, M.P.M. (author), Zwinderman, A.H. (author), Kastelein, J.J.P. (author), Rabelink, T.J. (author), van Boven, A.J. (author), Feskens, E.J.M. (author), Boer, J.M.A. (author), van der Wall, E.E. (author), Jukema, J.W. (author), Gaubius Instituut TNO (author)
In the present study, we sought to evaluate the role of three polymorphisms in the ecNOS (endothelial constitutive nitric oxide synthase) gene in relation to the existence, severity and progression of CAD (coronary artery disease), MI (myocardial infarction) and the occurrence of ischaemia in a predominantly Caucasian population. Patients with...
article 2004
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Agema, W.R.P. (author), Monraats, P.S. (author), Zwinderman, A.H. (author), de Winter, R.J. (author), Tio, R.A. (author), Doevendans, P.A.F.M. (author), Waltenberger, J. (author), de Maat, M.P.M. (author), Frants, R.R. (author), Atsma, D.E. (author), van der Laarse, A. (author), van der Wall, E.E. (author), Jukema, J.W. (author), Gaubius Instituut TNO (author)
Aims To document the practice of interventional cardiology and the clinical restenosis rate, as well as the risk factors for clinical restenosis in an unselected population of patients in daily practice and to provide a perspective for the need of new devices such as drug-eluting stents. Methods and results A total of 3177 consecutive patients,...
article 2004
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Gómez-Aracena, J. (author), Martin-Moreno, J.M. (author), Riemersma, R.A. (author), Bode, P. (author), Gutiérrez-Bedmar, M. (author), Gorgojo, L. (author), Kark, J.D. (author), Garcia-Rodríguez, A. (author), Gomez-Gracia, E. (author), Kardinaal, A.F.M. (author), Aro, A. (author), van 't Veer, P. (author), Wedel, H. (author), Kok, F.J. (author), Fernández-Crehuet, J. (author)
The association between scandium status and risk of acute myocardial infarction (MI) was examined in a multicentre case control study in 10 centres from Europe and Israel. Scandium in toenails was assessed in 684 cases and 724 controls less than 70 years of age. Mean concentrations of toenail scandium were 6.74 μg/kg in cases and 7.75 μg/kg in...
article 2002
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Guallar, E. (author), Aro, A. (author), Jiménez, F.J. (author), Martín-Moreno, J.M. (author), Salminen, I. (author), van 't Veer, P. (author), Kardinaal, A.F.M. (author), Gömez-Aracena, J. (author), Martin, B.C. (author), Kohlmeier, L. (author), Kark, J.D. (author), Mazaev, V.P. (author), Ringstad, J. (author), Guillén, J. (author), Riemersma, R.A. (author), Huttunen, J.K. (author), Thamm, M. (author), Kok, F.J. (author)
Omega-3 fatty acids have potential antiatherogenic, antithrombotic, and antiarrhythmic properties, but their role in coronary heart disease remains controversial. To evaluate the association of omega-3 fatty acids in adipose tissue with the risk of myocardial infarction in men, a case-control study was conducted in eight European countries and...
article 1999
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Klipstein-Grobusch, K. (author), Grobbee, D.E. (author), den Breeijen, J.H. (author), Boeing, H. (author), Hofman, A. (author), Witteman, J.C.M. (author)
Free iron has been implicated in lipid peroxidation and ischemic myocardial damage, and it has been suggested that iron is an independent risk factor for myocardial infarction. The authors investigated whether dietary iron is associated with an increased risk of fatal and nonfatal myocardial infarction in the Rotterdam Study, a community-based...
article 1999
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Su, L.C.J. (author), Bui, M. (author), Kardinaal, A. (author), Gomez-Aracena, J. (author), Martin-Moreno, J. (author), Martin, B. (author), Thamm, M. (author), Simonsen, N. (author), van 't Veer, P. (author), Kok, F. (author), Strain, S. (author), Kohlmeier, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Biomarkers of dietary exposure or nutritional status are sought actively to overcome limitations of traditional dietary methodology. We compared plasma and adipose tissue biomarkers for carotenoids and tocopherols. The data consisted of samples from 91 men and 122 women, ages 45-70 years, from the control group of the European Community...
article 1998
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Haverkate, F. (author), Thompson, S.G. (author), Pyke, S.D.M. (author), Gallimore, J.R. (author), Pepys, M.B. (author), TNO Preventie en Gezondheid (author)
Background. Inflammation is an important feature of atherosclerotic lesions, and increased production of the acute-phase reactant, C-reactive protein (CRP), is associated with a poor prognosis in severe unstable angina. We have investigated the existence and possible significance of the acute-phase responses of CRP and another sensitive reactant...
article 1997
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van der Bom, J.G. (author), de Knijff, P. (author), Haverkate, F. (author), Bots, M.L. (author), Meijer, P. (author), de Jong, P.T.V.M. (author), Hofman, A. (author), Kluft, C. (author), Grobbee, D.E. (author), Gaubius Instituut TNO (author)
Background: Impaired fibrinolytic capacity, as assessed by euglobulin clot lysis time or plasma concentration of fibrinolytic parameters, has been associated with an increased risk of myocardial infarction (MI). We studied the association of a polymorphism in the gene for TPA and of plasma concentrations of TPA (antigen and activity) with the...
article 1997
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Juhan-Vague, I. (author), Pyke, S.D.M. (author), Alessi, M.C. (author), Jespersen, J. (author), Haverkate, F. (author), Thompson, S.G. (author), Hematology Laboratory, CHU Timone, Marseille, France Medical Statistics Unit, London (UK) Sch. of Hyg./Trop. Med. Centralsygehuset, Esbjerg, Denmark Gaubius Laboratory Hematology Laboratory, CHU Timone, 13385 Marseille Cedex 5, France TNO Preventie en Gezondheid (author)
Background: Disturbances of the fibrinolytic system that lead to decreased removal of fibrin deposits may be important risk factors for coronary thrombosis. There is as yet no consensus on the prognostic value of fibrinolytic parameters, which may be attributed in part to the choice of confounding variables controlled for. Methods and Results:...
article 1996
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Iacoviello, L. (author), di Castelnuovo, A. (author), de Knijff, P. (author), d' Orazio, A. (author), Amore, C. (author), Kluft, C. (author), Donati, M.B. (author), Gaubius Instituut TNO (author)
Several authors have suggested that increased t-PA antigen levels were associated to thrombotic events in coronary, cerebral and peripheral arteries. Baseline and stimulated levels of t-PA in plasma appear highly heritable, therefore, it could be of interest to evaluate the role of genetic variations in the t-PA locus in determining its plasma...
article 1996
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van der Bom, J.G. (author), Bots, M.L. (author), Haverkate, F. (author), Slagboom, P.E. (author), Meijer, P. (author), de Jong, P.T.V.M. (author), Hofman, A. (author), Grobbee, D.E. (author), Kluft, C. (author), Gaubius Instituut TNO (author)
Background: Resistance to activated protein C (APC), which results from various factors, including a mutation in the gene for coagulant factor V, has been associated with increased risk for venous thrombosis. However, its relation to arterial disease is still not well defined. Objective: To investigate the association of both response to APC and...
article 1996
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van der Bom, J.G. (author), Bots, M.L. (author), Haverkate, F. (author), Grobbee, D.E. (author), Kluft, C. (author), Gaubius Instituut TNO (author)
article 1996
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