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Pouran, B. (author), Moshtagh, P.R. (author), Arbabi, V. (author), Snabel, J. (author), Stoop, R. (author), Ruberti, J. (author), Malda, J. (author), Zadpoor, A.A. (author), Weinans, H. (author)An important aspect in cartilage ageing is accumulation of advanced glycation end products (AGEs) after exposure to sugars. Advanced glycation results in cross-links formation between the collagen fibrils in articular cartilage, hampering their flexibility and making cartilage more brittle. In the current study, we investigate whether collagen...article 2018
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Deemter, M.V. (author), Bank, R.A. (author), Vehof, J. (author), Hooymans, J.M.M. (author), Los, L.I. (author)Purpose: To explore factors associated with pentosidine accumulation in the human vitreous. Methods: Vitreous samples were obtained during trans pars plana vitrectomy for macular hole or rhegmatogenous retinal detachment. Patient characteristics included age, gender, and diabetes mellitus. Ocular characteristics included pseudophakia, posterior...article 2017
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Verhoeckx, K.C.M. (author), Vissers, Y.M. (author), Baumert, J.L. (author), Faludi, R. (author), Feys, M. (author), Flanagan, S. (author), Herouet-Guicheney, C. (author), Holzhauser, T. (author), Shimojo, R. (author), van der Bolt, N. (author), Wichers, H. (author), Kimber, I. (author)Food processing can have many beneficial effects. However, processing may also alter the allergenic properties of food proteins. A wide variety of processing methods is available and their use depends largely on the food to be processed. In this review the impact of processing (heat and non-heat treatment) on the allergenic potential of proteins...article 2015
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Willems, N.M.B.K. (author), Langenbach, G.E.J. (author), Stoop, R. (author), den Toonder, J.M.J. (author), Mulder, L. (author), Zentner, A. (author), Everts, V. (author)The role of mature collagen cross-links, pentosidine (Pen) cross-links in particular, in the micromechanical properties of cancellous bone is unknown. The aim of this study was to examine nonenzymatic glycation effects on tissue stiffness of demineralized and non-demineralized cancellous bone. A total of 60 bone samples were derived from...article 2014
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Vos, P.A.J.M. (author), Welsing, P.M.J. (author), de Groot, J. (author), Huisman, A.M. (author), Oostveen, J.C.M. (author), Reijman, M. (author), Damen, J. (author), Mastbergen, S.C. (author), Lafeber, F.P.J.G. (author)Age-related changes in articular cartilage are likely to play a role in the etiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced glycation end products (AGEs). The present study evaluates whether pentosidine can predict radiographic progression and/or burden over 5 years follow-up in...article 2013
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Vos, P.A.J.M. (author), Mastbergen, S.C. (author), Huisman, A.M. (author), de Boer, T.N. (author), de Groot, J. (author), Polak, A.A. (author), Lafeber, F.P.J.G. (author)Objectives: Age is the most prominent predisposition for development of osteoarthritis (OA). Age-related changes of articular cartilage are likely to play a role. Advanced glycation endproducts (AGEs) accumulate in cartilage matrix with increasing age and adversely affect the biomechanical properties of the cartilage matrix and influence...article 2012
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Vos, P.A.J.M. (author), Degroot, J. (author), Barten-Van Rijbroek, A.D. (author), Zuurmond, A.-M. (author), Bijlsma, J.W.J. (author), Mastbergen, S.C. (author), Lafeber, F.P.J.G. (author)Osteoarthritis is a highly prevalent disease, age being the main risk factor. The age-related accumulation of advanced-glycation-endproducts (AGEs) adversely affects the mechanical and biochemical properties of cartilage. The hypothesis that accumulation of cartilage AGEs in combination with surgically induced damage predisposes to the...article 2012
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van Deemter, M. (author), Ponsioen, T.L. (author), Bank, R.A. (author), Snabel, J.M.M. (author), van der Worp, R.J. (author), Hooymans, J.M.M. (author), Los, L.I. (author), TNO Kwaliteit van Leven (author)The human vitreous body undergoes structural changes with aging. This can be followed by a posterior vitreous detachment, which can result in ocular pathology. As in many collagenous tissues, age-related changes in the vitreous could be caused by the formation of advanced glycation end products (AGEs). The goal of this study was to find out...article 2009
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Steenvoorden, M.M.C. (author), Toes, R.E.M. (author), Ronday, H.K. (author), Huizinga, T.W.J. (author), de Groot, J. (author), TNO Kwaliteit van Leven (author)Ligands for the receptor for advanced glycation endproducts (RAGE) are increased in RA synovial fluid (SF), serum and synovium. Since RAGE is present on fibroblast-like synoviocytes (FLS), the present study investigates whether the RAGE ligands HMGB-1 and AGEs are able to stimulate the characteristic, pathological invasive behaviour of these...article 2007
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Sivan, S.S. (author), Tsitron, E. (author), Wachtel, E. (author), Roughley, P. (author), Sakkee, N. (author), van der Ham, F. (author), de Groot, J. (author), Maroudas, A. (author), TNO Kwaliteit van Leven (author)During aging and degeneration, many changes occur in the structure and composition of human cartilaginous tissues, which include the accumulation of the AGE (advanced glycation end-product), pentosidine, in long-lived proteins. In the present study, we investigated the accumulation of pentosidine in constituents of the human IVD (intervertebral...article 2006
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TNO Kwaliteit van Leven (author), Steenvoorden, M.M.C. (author), Huizinga, T.W.J. (author), Verzijl, N. (author), Bank, R.A. (author), Ronday, H.K. (author), Luning, H.A.F. (author), Lafeber, F.P.J.G. (author), Toes, R.E.M. (author), de Groot, J. (author)Objective. The major risk factor for osteoarthritis (OA) is aging, but the mechanisms underlying this risk are only partly understood. Age-related accumulation of advanced glycation end products (AGEs) could be one of these mechanisms. We undertook this study to investigate the role of the receptor for AGEs (RAGE) in mediating the cellular...article 2006
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van Teeffelen, A.M.M. (author), Broersen, K. (author), de Jongh, H.H.J. (author), TNO Kwaliteit van Leven (author)Chemical glycosylation of proteins occurs in vivo spontaneously, especially under stress conditions, and has been linked in a number of cases to diseases related to protein denaturation and aggregation. It is the aim of this work to study the origin of the change in thermodynamic properties due to glucosylation of the folded β-lactoglobulin A....article 2005
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de Groot, J. (author)Accumulation of advanced glycation endproducts (AGEs) plays a crucial part in the development of age-related diseases and diabetic complications. AGEs are formed in vivo via the so-called Maillard reaction: a reducing sugar reacts with a protein to form a labile Amadori product that is subsequently stabilized, producing an irreversible, non...article 2004
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de Groot, J. (author), Verzijl, N. (author), van Wenting-Wijk, M.J.G. (author), Jacobs, K.M.G. (author), van El, B. (author), van Roermund, P.M. (author), Bank, R.A. (author), Bijlsma, J.W.J. (author), TeKoppele, J.M. (author), Lafeber, F.P.J.G. (author), TNO Preventie en Gezondheid (author)Objective. Osteoarthritis (OA) is one of the most prevalent and disabling chronic conditions affecting the elderly. Its etiology is largely unknown, but age is the most prominent risk factor. The current study was designed to test whether accumulation of advanced glycation end products (AGEs), which are known to adversely affect cartilage...article 2004
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Valencia, J.V. (author), Weldon, S.C. (author), Quinn, D. (author), Kiers, G.H. (author), de Groot, J. (author), TeKoppele, J.M. (author), Hughes, T.E. (author), Gaubius instituut TNO (author)Advanced glycation end products (AGEs) accumulate with age and at an accelerated rate in diabetes. AGEs bind cell-surface receptors including the receptor for advanced glycation end products (RAGE). The dependence of RAGE binding on specific biochemical characteristics of AGEs is currently unknown. Using standardized procedures and a variety of...article 2004
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Verzijl, N. (author), Bank, R.A. (author), TeKoppele, J.M. (author), de Groot, J. (author), TNO Preventie en Gezondheid Gaubius instituut TNO (author)Purpose of review: Across the world, osteoarthritis is the most commonly occurring musculoskeletal disease of the elderly, affecting more than 25% of the population older than 60 years of age. By far the single greatest risk factor for the development of osteoarthritis is age, but a mechanism to explain this relation has not yet been identified....article 2003
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Verzijl, N. (author), de Groot, J. (author), Zaken, C.B. (author), Braun-Benjamin, O. (author), Maroudas, A. (author), Bank, R.A. (author), Mizrahi, J. (author), Schalkwijk, C.G. (author), Thorpe, S.R. (author), Baynes, J.W. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), TeKoppele, J.M. (author), Gaubius Instituut TNO (author)Objective. Age is an important risk factor for osteoarthritis (OA). During aging, nonenzymatic glycation results in the accumulation of advanced glycation end products (AGEs) in cartilage collagen. We studied the effect of AGE crosslinking on the stiffness of the collagen network in human articular cartilage. Methods. To increase AGE levels,...article 2002
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Chen, A.C. (author), Temple, M.M. (author), Ng, D.M. (author), Verzijl, N. (author), de Groot, J. (author), TeKoppele, J.M. (author), Sah, R.L. (author)Objective. To determine whether increasing advanced glycation end products (AGEs) in bovine articular cartilage to levels present in aged human cartilage modulates the tensile biomechanical properties of the tissue. Methods. Adult bovine articular cartilage samples were incubated in a buffer solution with ribose to induce the formation of AGEs...article 2002
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Verzijl, N. (author), de Groot, J. (author), Bank, R.A. (author), Bayliss, M.T. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), Maroudas, A. (author), TeKoppele, J.M. (author), Gaubius Instituut (author)During aging, non-enzymatic glycation results in the formation and accumulation of the advanced glycation endproduct pentosidine in long-lived proteins, such as articular cartilage collagen. In the present study, we investigated whether pentosidine accumulation also occurs in cartilage aggrecan. Furthermore, pentosidine levels in aggrecan...article 2001
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de Groot, J. (author), Verzijl, N. (author), Budde, M. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), TeKoppele, J.M. (author), Gaubius Instituut (author)The integrity of the collagen network is essential for articular cartilage to fulfill its function in load support and distribution. Damage to the collagen network is one of the first characteristics of osteoarthritis. Since extensive collagen damage is considered irreversible, it is crucial that chondrocytes maintain a functional collagen...article 2001
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