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Weening-Verbree, L.F. (author), Schuller, A.A. (author), Zuidema, S.U. (author), Hobbelen, J.S.M. (author)An Oral Care Program (OCP) was implemented in home care nursing teams in a northern province of the Netherlands to improve the oral health and hygiene of older people who make use of formal home care in 2018-2019. The aim of the current study was to evaluate the experiences of the stakeholders involved (older people, home-care nurses and dental...article 2023
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Suchowerska, A.K. (author), Stokman, G. (author), Palmer, J.T. (author), Coghlan, P.A. (author), Pieterman, E.J. (author), Keijzer, N. (author), Lambert, G. (author), Chemello, K. (author), Jaafar, A.K. (author), Parmar, J. (author), Yan, L. (author), Tong, Y. (author), Mu, L. (author), Princen, H.M.G. (author), Bonnar, J. (author), Evison, B.J. (author)Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibits the clearance of low-density lipoprotein (LDL) cholesterol (LDL-C) from plasma by directly binding with the LDL receptor (LDLR) and sending the receptor for lysosomal degradation. As the interaction promotes elevated plasma LDL-C levels, and therefore a predisposition to...article 2022
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Rasheed, M.B. (author), Rodriguez Moreno, M.D. (author)This paper considers the time of use (TOU) pricing scheme to propose a consumer aware pricing policy (CAPP), where each customer receives a separate electricity pricing signal. These pricing signals are obtained based on individualized load demand patterns to optimally manage the flexible load demand. The main objective of CAPP is to reduce the...article 2022
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Fratric, P. (author), Sileno, G. (author), van Engers, T. (author), Klous, S. (author)The financial sector continues to experience wide digitalization; the resulting transactional activity creates large amounts of data, in principle enabling public and private actors to better understand the social domain they operate on, possibly facilitating the design of interventions to reduce illegal activity. However, the adversarial nature...conference paper 2022
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- Phillipson, F. (author), Bhatia, H.S. (author) conference paper 2021
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Bornet, A. (author), Doerig, A. (author), Herzog, M.H. (author), Francis, G. (author), van der Burg, E. (author)In crowding, perception of a target deteriorates in the presence of nearby flankers. Traditionally, it is thought that visual crowding obeys Bouma's law, i.e., all elements within a certain distance interfere with the target, and that adding more elements always leads to stronger crowding. Crowding is predominantly studied using sparse displays ...article 2021
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van Keulen, D. (author), van Koeverden, I.D. (author), Boltjes, A. (author), Princen, H.M.G. (author), van Gool, A.J. (author), de Borst, G.J. (author), Asselbergs, F.W. (author), Tempel, D. (author), Pasterkamp, G. (author), van der Laan, S.W. (author)Background and Aims: Oncostatin M (OSM) signaling is implicated in atherosclerosis, however the mechanism remains unclear. We investigated the impact of common genetic variants in OSM and its receptors, OSMR and LIFR, on overall plaque vulnerability, plaque phenotype, intraplaque OSMR and LIFR expression, coronary artery calcification burden and...article 2021
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Egberts, P.J.P. (author), Tümer, C. (author), Loh, K.K.L. (author), Octaviano, R. (author)Different stakeholders have different design considerations that shape a heating grid. In short term, theserange from achieving lowest ownership costs to preventing monopolies. In long term, project developersfocus on how uncertainties of design parameters (e.g. demand/supply, heat prices) affect the grid designand, ultimately, the business case...article 2020
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Naafs, J.C. (author), Verkerk, P.H. (author), Fliers, E. (author), van Trotsenburg, A.S.P. (author), Zwaveling-Soonawala, N. (author)Objective To evaluate clinical characteristics of patients with central congenital hypothyroidism (CH), detected in the Dutch neonatal screening program. This included patients with isolated central CH but the majority have multiple pituitary hormone deficiencies (MPHD). Design Nationwide, cross-sectional study. Methods Data was collected on...article 2020
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Bitzer, J. (author), Henkel, T. (author), Nikiforov, A.I. (author), Rihner, M.O. (author), Verspeek-Rip, C.M. (author), Usta, B. (author), van den Wijngaard, M. (author)A series of in vitro studies were conducted to assess the genetic toxicity of jelly mushroom glycolipids from Dacryopinax spathularia (herein referred to as “AM-1“). In the bacterial reverse mutation assay (Ames test), there was no evidence of mutagenic activity in any Salmonella typhimurium strains tested or in Escherichia coli strain WP2uvrA,...article 2019
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Saffre, F. (author), Gianini, G. (author), Hildmann, H. (author), Davies, J. (author), Bullock, S. (author), Damiani, E. (author), Deneubourg, J.L. (author)We investigate the hypothesis that long-term memory in populations of agents can lead to counterproductive emergent properties at the system level. Our investigation is framed in the context of a discrete, one-dimensional road-traffic congestion model: we investigate the influence of simple cognition in a population of rational commuter agents...article 2019
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Stock Williams, C.F.W. (author), Krishna Swamy, S. (author)Offshore wind farm managers and schedulers need to manage large numbers of wind turbine visits every day, in order to: repair minor faults; conduct inspections; and perform scheduled service operations. Daily schedules form a choice of which maintenance activities to conduct, taking account of: constraints on weather conditions, shifts, vessel...article 2019
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Tans, R. (author), van Diepen, J.A. (author), Bijlsma, S. (author), Verschuren, L. (author), Suppers, A. (author), Stienstra, R. (author), Wevers, R.A. (author), Tack, C.J. (author), Gloerich, J. (author), van Gool, A.J. (author)Background: Overweight and obesity can lead to adipose tissue inflammation, which causes insulin resistance and on the long-term type 2 diabetes mellitus (T2D). The inflammatory changes of obese-adipose tissue are characterized by macrophage infiltration and activation, but validated circulating biomarkers for adipose tissue inflammation for...article 2019
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van der Veen, D.J. (author), Döpp, C.M. (author), Siemonsma, P.C. (author), Nijhuis-van der Sanden, M.W.G. (author), de Swart, B.J.M. (author), Steultjens, E.M. (author)Background: Stroke has a major impact on survivors and their social environment. Care delivery is advocated to become more client-centered and home-based because of their positive impact on client outcomes. The objective of this study was to explore professionals' perspectives on the provision of Home-Based Stroke Rehabilitation (HBSR) in the...article 2019
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Mevissen, F.E.F. (author), van Empelen, P. (author), Watzeels, A. (author), van Duin, G. (author), Meijer, S. (author), van Lieshout, S. (author), Kok, G. (author)This paper describes the development of a Dutch online programme called Long Live Love+ focusing on positive, coercion-free relationships, contraception use, and the prevention of STIs, using the Intervention Mapping (IM) approach. All six steps of the approach were followed. Step 1 confirmed the need for a sexual health programme targeting...article 2018
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van Groen, B.D. (author), van de Steeg, E. (author), Mooij, M.G. (author), van Lipzig, M.M.H. (author), de Koning, B.A.E. (author), Verdijk, R.M. (author), Wortelboer, H.M. (author), Gaedigk, R. (author), Bi, C. (author), Leeder, S. (author), van Schaik, R.H.N. (author), van Rosmalen, J. (author), Tibboel, D. (author), Vaes, W.H. (author), de Wildt, S.N. (author)Background Hepatic membrane transporters are involved in the transport of many endogenous and exogenous compounds, including drugs. We aimed to study the relation of age with absolute transporter protein expression in a cohort of 62 mainly fetus and newborn samples. Methods Protein expressions of BCRP, BSEP, GLUT1, MCT1, MDR1, MRP1, MRP2, MRP3,...article 2018
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Bouwhuis, S. (author), de Wind, A. (author), de Kruif, A. (author), van der Beek, A.J. (author), Bongers, P.M. (author), Boot, C.R.L. (author)Background. Multiple job holding (MJH) is a common and growing phenomenon in many countries. Little is known about experiences with MJH among older workers. The objective of the present study is to gain insight in experiences with MJH among Dutch workers aged 45 years and older. Methods. Multiple job holders were selected from the Study on...article 2018
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de Groot, J.F. (author), Damen, N. (author), de Loos, E. (author), Goorhuis, J. (author), Wagner, C. (author)Background: Paediatric Early Warning Scores (PEWS) are increasingly being used for early identification and management of clinical deterioration in paediatric patients. A PEWS system includes scores, cut-off points and appropriate early intervention. In 2011, The Dutch Ministry of Health advised hospitals to implement a PEWS system in order to...article 2018
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Shankar, K. (author), Pivik, R.T. (author), Johnson, S.L. (author), van Ommen, B. (author), Demmer, E. (author), Murray, R. (author)Understanding health requires more than knowledge of the genome. Environmental factors regulate gene function through epigenetics. Collectively, environmental exposures have been called the "exposome." Caregivers are instrumental in shaping exposures in a child's initial years. Maternal dietary patterns, physical activity, degree of weight gain,...article 2018
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Rusli, F. (author), Boekschoten, M.V. (author), Borelli, V. (author), Sun, C. (author), Lute, C. (author), Menke, A.L. (author), van den Heuvel, J. (author), Salvioli, S. (author), Franceschi, C. (author), Müller, M. (author), Steegenga, W.T. (author)Calorie restriction (CR) is a dietary regimen that supports healthy aging. In this study, we investigated the systemic and liver-specific responses caused by a diet switch to a medium-fat (MF) diet in 24-month-old lifelong, CR-exposed mice. This study aimed to increase the knowledge base on dietary alterations of gerontological relevance. Nine...article 2018