Apolipoprotein e4 allele and cognitive decline in elderly men

Objectives - To determine whether polymorphism of apolipoprotein E - notably, the e4 allele - predicts cognitive deterioration in the general population. Design - Population based cohort investigated in 1990 and in 1993. Setting - Zutphen, the Netherlands. Subjects - Representative cohort of 538 Dutch men aged 70-89 at baseline. Main outcome...

Prognostic relevance of plasminogen activators and their inhibitors in colorectal cancer

Human colorectal carcinogenesis has been shown previously to be associated with impressive changes in the tissue levels of plasminogen activators and their inhibitors, exemplified by an increase in the urokinase-type plasminogen activator (u-PA) and the inhibitors PAI-1 and PAI-2, and a decrease in tissue-type plasminogen activator (t-PA). In...

Impaired prenatal and postnatal growth in Dutch patients with phenylketonuria

Objective - To assess whether physical growth is affected in early treated Dutch patients with phenylketonuria (PKU). Methods - The birth weights of all 137 early detected patients with PKU born in the period from 1974 to 1988 in the Netherlands were compared with reference values. Height, head circumference, and weight were measured at the age...

Prospective study on alcohol consumption and the risk of cancer of the colon and rectum in the Netherlands

The association between alcohol consumption and cancer of the colon and rectum was investigated in a prospective cohort study, conducted in the Netherlands from 1986 onwards among 120,852 men and women, aged 55 to 69 years. During 3.3 years of follow-up, 312 and 166 cases of colon and rectal cancer had accumulated, respectively. After exclusion...

School performance at nine years of age in very premature and very low birth weight infants: Perinatal risk factors and predictors at five years of age

To assess the impact of both perinatal disorders and developmental problems identified at preschool age on school performance, we followed a virtually complete birth cohort of very premature (<32 completed weeks of gestation) and very low birth weight infants until they were 9 years of age. In 84% of the survivors (n = 813), data on school...

Gezondheidsproblemen na ernstige vroeggeboorte: 9 jaar naonderzoek [Health problems after very premature birth; nine years follow-up]

Evaluation of care for the preterm infant: Review of literature on follow-up of preterm and low birthweight infants : Report from the collaborative Project On Preterm and Small for gestational age infants (POPS) in The Netherlands

Since the introduction of neonatal intensive care in the 1960s, mortality in very preterm and very low birthweight infants has been decreasing steadily. Consequently, interest in the outcome of surviving infants is growing. Restriction of health care resources has stressed the need for information concerning the effect of individual treatment...

SMOCC: Design of a representative cohort-study of live-born infants in the Netherlands

The Social Medical Survey of Children attending Child Health Clinics (SMOCC) was initiated to obtain reference data on morbidity in children in their first two years of life. During 1988 and 1989, the staff of 21 Child Health Clinics recorded data on the pre- and perinatal period, and on the first two years of life, of infants born in the...

Transient hypothyroxinaemia associated with developmental delay in very preterm infants

In 563 surviving very preterm (<32 weeks gestational age) and/or very low birthweight (<1500 g) infants the relationship between neonatal thyroxine concentration and psychomotor development at 2 years of age (corrected for preterm birth) was studied. A significant association was found between low neonatal thyroxine concentration and a negative...

Grafting of venous leg ulcers. An intraindividual comparison between cultured skin equivalents and full-thickness skin punch grafts

Skin equivalents that consisted of a noncontracted collagen gel populated with allogeneic fibroblasts and covered with autologous cultured keratinocytes were used for grafting venous leg ulcers. The results were compared in the same patient with those obtained with a routinely used standard method of grafting with autologous full-thickness punch...

Elevated plasminogen activator inhibitor (PAI), a cause of thrombophilia? A study in 203 patients with familial or sporadic venous thrombophilia

Two hundred and three patients with venous thrombophilia were investigated in order to find out whether an elevated plasma concentration of plasminogen activator inhibitor (PAI) could be a cause of their tendency to thrombosis. The patients were studied in an asymptomatic period about 3 months after their last thromboembolic episode. PAI...