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- Jin, Y. (author), Behrens, P. (author), Tukker, A. (author), Scherer, L. (author) article 2022
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Ripken, D. (author), van der Wielen, N. (author), van der Meulen, J. (author), Schuurman, T. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author), Koopmans, S.J. (author)The vagal nerve and gut hormones CCK and GLP-1 play important roles in the control of food intake. However, it is not clear to what extent CCK and GLP-1 increase satiation by stimulating receptors located on abdominal vagal nerve endings or via receptors located elsewhere. This study aimed to further explore the relative contribution of the...article 2015
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Gerards, S.M.P.L. (author), Dagnelie, P.C. (author), Gubbels, J.S. (author), van Buuren, S. (author), Hamers, F.J.M. (author), Jansen, M.W.J. (author), van der Goot, O.H.M. (author), de Vries, N.K. (author), Sanders, M.R. (author), Kremers, S.P.J. (author)Introduction Lifestyle Triple P is a general parenting intervention which focuses on preventing further excessive weight gain in overweight and obese children. The objective of the current study was to assess the effectiveness of the Lifestyle Triple P intervention in the Netherlands. Method We used a parallel randomized controlled design to...article 2015
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Deckers, I.A.G. (author), van den Brandt, P.A. (author), van Engeland, M. (author), Soetekouw, P.M.M.B. (author), Baldewijns, M.M.L.L. (author), Goldbohm, R.A. (author), Schouten, L.J. (author)Background:As sodium, potassium and fluid intake are related to hypertension, an established risk factor for renal cell cancer (RCC), they may be independent risk factors for RCC.Methods:The Netherlands Cohort Study (NLCS) with case-cohort design included 120 852 participants aged 55-69 years. At baseline, diet and lifestyle were assessed with...article 2014
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Mons, M.N. (author), van der Wielen, J.M.L. (author), Blokker, E.J.M. (author), Sinclair, M.I. (author), Hulshof, K.F.A.M. (author), Dangendorf, F. (author), Hunter, P.R. (author), Medema, G.J. (author), TNO Kwaliteit van Leven (author)The volume of cold tap water consumed is an essential element in quantitative microbial risk assessment. This paper presents a review of tap water consumption studies. Study designs were evaluated and statistical distributions were fitted to water consumption data from The Netherlands, Great Britain, Germany and Australia. We conclude that the...article 2007
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TNO Kwaliteit van Leven (author), Beulens, J.W.J. (author), van Loon, L.J.C. (author), Kok, F.J. (author), Pelsers, M. (author), Bobbert, T. (author), Spranger, J. (author), Helander, A. (author), Hendriks, H.F.J. (author)Aims/hypothesis: The aim of this study was to investigate whether moderate alcohol consumption increases plasma high molecular weight (HMW) adiponectin and/or muscle oxidative capacity. Materials and methods: Eleven lean (BMI 18-25 kg/m2) and eight overweight (BMI ≥27 kg/m2) men consumed 100 ml whisky (∼32 g alcohol) or water daily for 4 weeks...article 2007
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Appel, M.J. (author), van Veen, H.A. (author), Vietsch, H. (author), Salaheddine, M. (author), Nuijens, J.H. (author), Ziere, B. (author), de Loos, F. (author), TNO Kwaliteit van Leven (author)The oral toxicity of recombinant human lactoferrin (rhLF) produced in the milk of transgenic cows was investigated in Wistar rats by daily administration via oral gavage for 13 consecutive weeks, 7 days per week. The study used four groups of 20 rats/sex/dose. The control group received physiological saline and the three test groups received...article 2006
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Smeets, P.A.M. (author), de Graaf, C. (author), Stafleu, A. (author), van Osch, M.J.P. (author), van der Grond, J. (author), TNO Kwaliteit van Leven (author)Background: Evidence exists that beverages do not trigger appropriate anticipatory physiologic responses, such as cephalic phase insulin release. Therefore, it is of interest to elucidate the food properties necessary for triggering adaptive responses. Previously, we found a prolonged dose-dependent decrease in the hypothalamic functional...article 2005
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Smeets, P.A.M. (author), de Graaf, C. (author), Stafleu, A. (author), van Osch, M.J.P. (author), van der Grond, J. (author), TNO Kwaliteit van Leven (author)The hypothalamus is intimately involved in the regulation of food intake, integrating multiple neural and hormonal signals. Several hypothalamic nuclei contain glucose-sensitive neurons, which play a crucial role in energy homeostasis. Although a few functional magnetic resonance imaging (fMRI) studies have indicated that glucose consumption has...article 2005
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Rietjens, G.J.W.M. (author), van Arensbergen, W. (author), Daanen, H.A.M. (author)An elevated core temperature is one of the underlying factors responsible for a decrease of performance during exercise in a hot environment. Therefore, strategies that minimise the rise in core temperature during exercise in the heat are likely to be effective in enhancing exercise performance. There are several strategies to minimise this...article 2004
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Waalkens-Berendsen, D.H. (author), Bär, A. (author), TNO Voeding (author)The embryotoxicity/teratogenicity of α-cyclodextrin (α-CD) was examined in Wistar Crl:(WI)WU BR rats. α-CD was fed at dietary concentrations of 0, 1.5, 5, 10, or 20% to groups of 25 pregnant female rats from day 0 to 21 of gestation. An additional group received a diet with 20% lactose. The additions to the diet of α-CD and lactose were made at...article 2004
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Lambert, J. (author), Agostoni, C. (author), Elmadfa, I. (author), Hulshof, K. (author), Krause, E. (author), Livingstone, B. (author), Socha, P. (author), Pannemans, D. (author), Samartín, S. (author)The objective of this project was to collect and evaluate data on nutrient intake and status across Europe and to ascertain whether any trends could be identified. Surveys of dietary intake and status were collected from across Europe by literature search and personal contact with country experts. Surveys that satisfied a defined set of criteria...article 2004
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Beulens, J.W.J. (author), Sierksma, A. (author), van Tol, A. (author), Fournier, N. (author), van Gent, T. (author), Paul, J.L. (author), Hendriks, H.F.J. (author)Moderate alcohol consumption increases HDL cholesterol, which is involved in reverse cholesterol transport (RCT). The aim of this study was to investigate the effect of moderate alcohol consumption on cholesterol efflux, using J774 mouse macrophages and Fu5AH cells, and on other parameters in the RCT pathway. Twenty-three healthy men (45-65...article 2004
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Boelsma, E. (author), van de Vijver, L.P.L. (author), Goldbohm, R.A. (author), Klöpping-Ketelaars, I.A.A. (author), Hendriks, H.F.J. (author), Roza, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Background: Nutritional factors exert promising actions on the skin, but only scant information is available on the modulating effects of physiologic concentrations of nutrients on the skin condition of humans. Objective: The objective was to evaluate whether nutrient concentrations in serum and diet are associated with the skin condition of...article 2003
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Delaney, B. (author), Carlson, T. (author), Frazer, S. (author), Zheng, T. (author), Hess, R. (author), Ostergren, K. (author), Kierzek, K. (author), Haworth, J. (author), Knutson, N. (author), Junker, K. (author), Jonker, D. (author), TNO Voeding (author)β-Glucans are water-soluble cell-wall polysaccharides consisting of (1→3,1→4)-linked β-D-glucopyranosyl monomers that comprise a considerable proportion of soluble fiber from certain grains including oats and barley. Consumption of foods containing β-glucan or β-glucan-enriched fractions prepared from these grains lower serum cholesterol...article 2003
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TNO Voeding (author), Vente-Spreeuwenberg, M.A.M. (author), Verdonk, J.M.A.J. (author), Verstegen, M.W.A. (author), Beynen, A.C. (author)The present study was designed to evaluate the differential effects of dietary glucose, lactose and starch on small-intestinal morphology, organ weights, pH of chyme and haptoglobin levels in blood plasma of weaned piglets. It was hypothesised that lactose consumption would ameliorate the weaning-induced decrease in gut integrity. A total of...article 2003
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Jonker, D. (author), Lina, B.A.R. (author), Kozianowski, G. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)The potential subchronic oral toxicity of isomaltulose (Palatinose®) was examined by administering this substance in the diet to groups of 20 male and 20 female Wistar rats at levels of 0, 2.5, 5 and 10% for 13 consecutive weeks. Daily clinical observations, body weight, food conversion efficiency, food and water consumption were not affected at...article 2002
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Missmer, S.A. (author), Smith-Warner, S.A. (author), Spiegelman, D. (author), Yaun, S.-S. (author), Adami, H.-O. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Fraserf, G.E. (author), Freudenheim, J.L. (author), Goldbohm, R.A. (author), Graham, S. (author), Kushi, L.H. (author), Miller, A.B. (author), Potter, J.D. (author), Rohan, T.E. (author), Speizer, F.E. (author), Toniolo, P. (author), Willett, W.C. (author), Wolk, A. (author), Zeleniuch-Jacquotte, A. (author), Hunter, D.J. (author)Background. More than 20 studies have investigated the relation between meat and dairy consumption and breast cancer risk with conflicting results. Our objective was evaluate the risk of breast cancer associated with meat and dairy food consumption and to assess whether non-dietary risk factors modify the relation. Methods. We combined the...article 2002
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Lina, B.A.R. (author), van Garderen-Hoetmer, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Systemic alkalosis has been postulated to enhance tumorigenesis, whereas systemic acidosis has been implicated to exert a favourable influence on tumour control and regression. In the present study the urinary pH was influenced by feeding acid-forming or base-forming diets, and the effect of alkaline or acid urine on the early and late...article 1999
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Lina, B.A.R. (author), Bär, A. (author)The toxicity of γ-cyclodextrin (γ-CD), a cyclic polymer of eight α-1,4-linked glucopyranosyl units with potential applications as a food ingredient, was examined in a 2-week pilot study followed by a 13-week oral toxicity study in Wistar rats. In the 2-week study, the test substance was administered to groups of 5 male rats at dietary levels of...article 1998
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