Searched for: subject%3A%22evidence%255C%2Bbased%255C%2Bmedicine%22
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Sewell, F. (author), Strupp, C. (author), van der Laan, J.W. (author), Wolf, D.C. (author), Wolterink, G. (author), Woutersen, R. (author), Zvonar, Z. (author), Heusinkveld, H. (author), Braakhuis, H. (author)
Currently the only methods for non-genotoxic carcinogenic hazard assessment accepted by most regulatory authorities are lifetime carcinogenicity studies. However, these involve the use of large numbers of animals and the relevance of their predictive power and results has been scientifically challenged. With increased availability of innovative...
article 2020
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Deurloo, J.A. (author), Verkerk, P.H. (author)
Objectives: Over the years, there has been much debate about the desirability and efficacy of screening for adolescent idiopathic scoliosis. To analyse the current evidence from a public health point of view a renewed evaluation of the literature was performed. Study design: Literature review. Methods: We performed two literature searches: from...
article 2015
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Mihaescu, R. (author), Detmar, S.B. (author), Cornel, M.C. (author), van der Flier, W.M. (author), Heutink, P. (author), Hol, E.M. (author), Rikkert, M.G.M.O. (author), van Duijn, C.M. (author), Janssens, A.C.J.W. (author), TNO Kwaliteit van leven (author)
Alzheimer's disease (AD) is the most prevalent form of dementia and the number of cases is expected to increase exponentially worldwide. Three highly penetrant genes (AβPP, PSEN1, and PSEN2) explain only a small number of AD cases with a Mendelian transmission pattern. Many genes have been analyzed for association with non-Mendelian AD, but the...
article 2010
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TNO Kwaliteit van Leven (author), Altorf, W. (author), van der Kuil, W.A. (author), Engberink, M.F. (author), Brink, E.J. (author), van Baak, M.A. (author), Bakker, S.J.L. (author), Navis, G. (author), van't Veer, P. (author), Geleijnse, J.M. (author)
Background: Elevated blood pressure (BP), which is a major risk factor for cardiovascular disease, is highly prevalent worldwide. Recently, interest has grown in the role of dietary protein in human BP. We performed a systematic review of all published scientific literature on dietary protein, including protein from various sources, in relation...
article 2010
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TNO Kwaliteit van Leven (author), Matthys, C. (author), Bucchini, L. (author), Busstra, M.C. (author), Cavelaars, A.E.J.M. (author), Eleftheriou, P. (author), Garc?a-Alvarez, A. (author), Fairweather-Tait, S. (author), Gurinovi?, M. (author), van Ommen, B. (author), Contor, L. (author)
Approaches through which reference values for micronutrients are derived, as well as the reference values themselves, vary considerably across countries. Harmonisation is needed to improve nutrition policy and public health strategies. The EURRECA (EURopean micronutrient RECommendations Aligned, http://www.eurreca.org) Network of Excellence is...
article 2010
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Ashwell, M. (author), Lambert, J.P. (author), Alles, M.S. (author), Branca, F. (author), Bucchini, L. (author), Brzozowska, A. (author), de Groot, L.C.P.G.M. (author), Dhonukshe-Rutten, R.A.M. (author), Dwyer, J.T. (author), Fairweather-Tait, S. (author), Koletzko, B. (author), Pavlovic, M. (author), Raats, M.M. (author), Serra-Majem, L. (author), Smith, R. (author), van Ommen, B. (author), Veer, P.V. (author), Von Rosen, J. (author), Pijls, L.T.J. (author), TNO Kwaliteit van Leven (author)
Background: There is considerable variation in the recommended micronutrient intakes used by countries within Europe, partly due to different methodologies and concepts used to determine requirements and different approaches used to express the recommendations. As populations become more mobile and multi-national, and more traditional foods...
article 2008
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Fransman, W. (author), Schinkel, J. (author), Meijster, T. (author), van Hemmen, J. (author), Tielemans, E. (author), Goede, H. (author), TNO Kwaliteit van Leven (author)
Objectives: This paper describes the development and evaluation of an evidence database on the effectiveness of risk management measures (RMMs) to control inhalation exposure. This database is referred to as Exposure Control Efficacy Library (ECEL). Methods: A comprehensive review of scientific journals in the occupational hygiene field was...
article 2008
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van Dommelen, P. (author), van Wouwe, J.P. (author), Breuning-Boers, J.M. (author), van Buuren, S. (author), Verkerk, P.H. (author), TNO Kwaliteit van Leven (author)
Objective: The validity of the rule of thumb that infants may have a weight loss of 10% in the first days after birth is unknown. We assessed the validity of this and other rules to detect breast-fed infants with hypernatraemic dehydration. Design: A reference chart for relative weight change was constructed by the LMS method. The reference...
article 2007
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Goldbohm, R.A. (author), Tielemans, E.L.J.P. (author), Heederik, D. (author), Rubingh, C.M. (author), Dekkers, S. (author), Willems, M.I. (author), Dinant Kroese, E. (author), TNO Kwaliteit van Leven (author)
It is generally recognized that human, epidemiological data, if available, are preferred as the starting point for quantitative risk analysis above the use of data from animal studies. Although methods to obtain proper risk estimates from epidemiological data are available, several impediments prevent their widespread application. These...
article 2006
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van Buuren, S. (author), Boshuizen, H.C. (author), Reijneveld, S.A. (author), TNO Kwaliteit van Leven (author)
Background. Guidelines for screening and subsequent treatment of hypertension vary widely between countries. Part of this variation can be attributed to systematic differences between populations, but little is known about the way in which guidelines should be targeted to the population of interest. Optimal guidelines should have high yield and...
article 2006
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Heerdink-Obenhuijsen, N. (author), Kamphuis, M. (author), Fleuren, M.A.H. (author), van Velzen-Mol, H.W.M. (author), de Wilde, J.A. (author), TNO Kwaliteit van Leven (author)
The Dutch Child Health Care guideline on the early detection of congenital heart disease was developed according to the principles for evidence-based guideline development and contains recommendations for the conduct of the examination during routine check-ups and for referral criteria. Most congenital heart diseases can be detected in the first...
article 2006
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van Dommelen, P. (author), van Buuren, S. (author), Zandwijken, G.R.J. (author), Verkerk, P.H. (author), TNO Kwaliteit van Leven (author)
The goal of this study is to assess whether a growth curve model approach will lead to a more precise detection of Turner sydnrome (TS) than conventional referral criteria for growth monitoring. The Jenss-Bayley growth curve model was used to describe the process of growth over time. A new screening rule is defined on the parameters of this...
article 2005
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Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Although obesity is an established risk factor for endometrial cancer, evidence linking risk to height, weight change since age 20, and physical activity is limited. In this case-cohort study, 62 573 women from The Netherlands Cohort Study on Diet and Cancer were followed up from 1986 to 1995, and 226 endometrial cancer case patients were...
article 2004
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de Jong, O.R.W. (author), Hopman-Rock, M. (author), Tak, E.C.M.P. (author), Klazinga, N.S. (author), TNO Preventie en Gezondheid (author)
Implementation studies are recommended to assess the feasibility and effectiveness in real-life of programmes which have been tested in randomized controlled trials (RCTs). We report on an implementation study of two evidence-based exercise and health education programmes for older adults with osteoarthritis (OA) of the knee of hip. Three types...
article 2004
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van Poppel, M.N.M. (author), Hooftman, W.E. (author), Koes, B.W. (author)
Objective. To update the evidence on the effectiveness of lumbar supports, education and exercise in the primary prevention of low back pain at the workplace. Methods. A computerized search for controlled clinical trials published between 1997 and 2002 was conducted, and the methodological quality of the studies was assessed using a criteria...
article 2004
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de Maat, M.P.M. (author), Trion, A. (author), TNO Preventie en Gezondheid (author)
Purpose of review C-reactive protein (CRP) is consistently associated with cardiovascular disease in prospective and cross-sectional clinical and epidemiological studies. Inflammation is an important mechanism in cardiovascular disease, and the plasma level of CRP is considered to. reflect the inflammatory condition of the patient and/or the...
article 2004
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TNO Arbeid (author), Hooftman, W.E. (author), van Poppel, M.N.M. (author), van der Beek, A.J. (author), Bongers, P.M. (author), van Mechelen, W. (author)
Gender differences in the prevalence of musculoskeletal complaints might be explained by differences in the effect of exposure to work-related physical and psychosocial risk factors. A systematic review was conducted to examine gender differences in the relations between these risk factors and musculoskeletal complaints. Several electronic...
article 2004
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Goede, H.A. (author), Tijssen, S.C.H.A. (author), Schipper, H.J. (author), Warren, N. (author), Oppl, R. (author), Kalberlah, F. (author), van Hemmen, J.J. (author), TNO Voeding (author)
This paper describes how default dermal exposure values can be adjusted with modifier values for specific work situations. The work presented here is supplementary to a toolkit developed for the EU RISKOFDERM project. This toolkit is intended for the assessment and management of dermal risks in small and medium sized enterprises. Potential...
article 2003
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Jansen, S.C. (author), van Dusseldorp, M. (author), Bottema, K.C. (author), Dubois, A.E.J. (author)
Objective: To evaluate the scientific evidence for purported intolerance to dietary biogenic amines. Data Sources: MEDLINE was searched for articles in the English language published between January 1966 and August 2001. The keyword biogenic amin* was combined with hypersens*, allerg*, intoler*, and adverse. Additionally, the keywords histamine,...
article 2003
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), Valtueña, S. (author), Cashman, K. (author), Robins, S.P. (author), Cassidy, A. (author), Kardinaal, A. (author), Branca, F. (author)
Research on the bone effects of natural phyto-oestrogens after menopause is at a relatively early stage. Published studies are few, difficult to compare and often inconclusive, due in part to design weaknesses. Currently, many questions remain to be answered including to what extent a safe daily intake may prevent postmenopausal bone loss. These...
article 2003
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