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TNO Preventie en Gezondheid (author), Lindahl, U. (author), Li, J.P. (author), Kusche-Gullberg, M. (author), Salmivirta, M. (author), Alaranta, S. (author), Veromaa, T. (author), Emeis, J. (author), Roberts, I. (author), Taylor, C. (author), Oreste, P. (author), Zoppetti, G. (author), Naggi, A. (author), Torri, G. (author), Casu, B. (author)Heparin remains a major drug in prevention of thromboembolic disease. Concerns related to its animal source have prompted search for heparin analogues. The anticoagulant activity of heparin depends on a specific pentasaccharide sequence that binds antithrombin. We report the generation of a product with antithrombin-binding, anticoagulant, and...article 2005
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- Bos, R. (author), Nieuwenhuizen, W. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author) article 1992
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Nieuwenhuizen, W. (author), Voskuilen, M. (author), Hermans, J. (author), Gaubius instituut TNO (author)The present study was undertaken as a step to delineate further the localization of the calcium-binding sites in fibrinogen and to assess the anticlotting properties of fibrinogen degradation products. To this purpose, fragments Y were prepared by plasmin digestion of human fibrinogen in the presence of added Ca2+, and purified. We found that,...article 1982
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Davidse, L.C. (author), Flach, W. (author), Centrum voor Plantenfysiologisch Onderzoek Nationale Raad voor Landbouwkundig Onderzoek TNO (author)Chemicals/CAS: benomyl, 17804-35-2; carbon 14, 14762-75-5; colchicine, 64-86-8; fuberidazole, 3878-19-1; griseofulvin, 126-07-8; mebendazole, 31431-39-7; melatonin, 73-31-4; nocodazole, 31430-18-9; parbendazole, 14255-87-9; podophyllotoxin, 518-28-5; tiabendazole, 148-79-8; vinblastine, 865-21-4; Benzimidazoles; Carbamates; Colchicine, 64-86-8;...article 1977