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Tans, R. (author), van Diepen, J.A. (author), Bijlsma, S. (author), Verschuren, L. (author), Suppers, A. (author), Stienstra, R. (author), Wevers, R.A. (author), Tack, C.J. (author), Gloerich, J. (author), van Gool, A.J. (author)Background: Overweight and obesity can lead to adipose tissue inflammation, which causes insulin resistance and on the long-term type 2 diabetes mellitus (T2D). The inflammatory changes of obese-adipose tissue are characterized by macrophage infiltration and activation, but validated circulating biomarkers for adipose tissue inflammation for...article 2019
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Fallaize, R. (author), Livingstone, K.M. (author), Celis-Morales, C. (author), Macready, A.L. (author), San-Cristobal, R. (author), Navas-Carretero, S. (author), Marsaux, C.F.M. (author), O’Donovan, C.B. (author), Kolossa, S. (author), Moschonis, G. (author), Walsh, M.C. (author), Gibney, E.R. (author), Brennan, L. (author), Bouwman, J. (author), Manios, Y. (author), Jarosz, M. (author), Martinez, J.A. (author), Daniel, H. (author), Saris, W.H.M. (author), Gundersen, T.E. (author), Drevon, C.A. (author), Gibney, M.J. (author), Mathers, J.C. (author), Lovegrove, J.A. (author)Diet-quality scores (DQS), which are developed across the globe, are used to define adherence to specific eating patterns and have been associated with risk of coronary heart disease and type-II diabetes. We explored the association between five diet-quality scores (Healthy Eating Index, HEI; Alternate Healthy Eating Index, AHEI; MedDietScore,...article 2018
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Masthoff, L.J.N. (author), Blom, W.M. (author), Rubingh, C.M. (author), Klemans, R.J.B. (author), Remington, B.C. (author), Bruijnzeel-Koomen, C.A.F.M. (author), van Hoffen, E. (author), Houben, G.F. (author), Meyer, Y. (author), Pasmans, S.G.M.A. (author), Knulst, A.C. (author)[No abstract available] Chemicals / CAS immunoglobulin E, 37341-29-0; Allergens; Antigens, Plant; Cor a 14 allergen, hazelnut; Cor a 9 protein, hazelnut; Immunoglobulin E; Plant Proteins.article 2018
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Fransson, E.I. (author), Nyberg, S.T. (author), Heikkilä, K. (author), Alfredsson, L. (author), Bjorner, J.B. (author), Borritz, M. (author), Burr, H. (author), Dragano, N. (author), Geuskens, G.A. (author), Goldberg, M. (author), Hamer, M. (author), Hooftman, W.E. (author), Houtman, I.L. (author), Joensuu, M. (author), Jokela, M. (author), Knutsson, A. (author), Koskenvuo, M. (author), Koskinen, A. (author), Kumari, M. (author), Leineweber, C. (author), Lunau, T. (author), Madsen, I.E.H. (author), Hanson, L.L.M. (author), Nielsen, M.L. (author), Nordin, M. (author), Oksanen, T. (author), Pentti, J. (author), Pejtersen, J.H. (author), Rugulies, R. (author), Salo, P. (author), Shipley, M.J. (author), Steptoe, A. (author), Suominen, S.B. (author), Theorell, T. (author), Toppinen-Tanner, S. (author), Vahtera, J. (author), Virtanen, M. (author), Väänänen, A. (author), Westerholm, P.J.M. (author), Westerlund, H. (author), Zins, M. (author), Britton, A. (author), Brunner, E.J. (author), Singh-Manoux, A. (author), Batty, G.D. (author), Kivimäki, M. (author)BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain. METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between...article 2015
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de Lange-Brokaar, B.J.E. (author), Ioan-Facsinay, A. (author), Yusuf, E. (author), Visser, A.W. (author), Kroon, H.M. (author), van Osch, G.J.V.M. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Bloem, J.L. (author), Nelissen, R.G.H.H. (author), Huizinga, T.W. (author), Kloppenburg, M. (author)Objective To determine possible patterns of synovitis on contrast-enhanced magnetic resonance imaging (CE-MRI) and its relation to pain and severity in patients with radiographic knee osteoarthritis (OA). Methods In total, 86 patients (mean age 62 years, 66% women, median body mass index 29 kg/m2) with symptomatic knee OA (Kellgren/Lawrence...article 2015
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Mulder, P. (author), Stavro, P.M. (author), Manuel Suárez, M. (author), Arola-Arnal, A. (author), van Duyvenvoorde, W. (author), Kooistra, T. (author), Wielinga, P.Y. (author), Kleemann, R. (author)Background and Aims As dietary saturated fatty acids are associated with metabolic and cardiovascular disease, a potentially interesting strategy to reduce disease risk is modification of the quality of fat consumed. Vegetable oils represent an attractive target for intervention, as they largely determine the intake of dietary fats. Furthermore,...article 2015
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Kühnast, S. (author), Fiocco, M. (author), van der Hoorn, J.W.A. (author), Princen, H.M.G. (author), Jukema, J.W. (author)Non-HDL-cholesterol is well recognised as a primary causal risk factor in cardiovascular disease. However, despite consistent epidemiological evidence for an inverse association between HDL-C and coronary heart disease, clinical trials aimed at raising HDL-C (AIM-HIGH, HPS2-THRIVE, dal-OUTCOMES) failed to meet their primary goals. This...article 2015
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Busnadiego, O. (author), Gorbenko del Blanco, D. (author), González-Santamaría, J. (author), Habashi, J.P. (author), Calderon, J.F. (author), Sandoval, P. (author), Bedja, D. (author), Guinea-Viniegra, J. (author), Lopez-Cabrera, M. (author), Rosell-Garcia, T. (author), Snabel, J.M. (author), Hanemaaijer, R. (author), Forteza, A. (author), Dietz, H.C. (author), Egea, G. (author), Rodriguez-Pascual, F. (author)Patients with Marfan syndrome (MFS) are at high risk of life-threatening aortic dissections. The condition is caused by mutations in the gene encoding fibrillin-1, an essential component in the formation of elastic fibers. While experimental findings in animal models of the disease have shown the involvement of transforming growth factor-β (TGF...article 2015
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Borgdorff, H. (author), Verwijs, M.C. (author), Wit, F.W.N.M. (author), Tsivtsivadze, E. (author), Ndayisaba, G.F. (author), Verhelst, R. (author), Schuren, F.H. (author), van de Wijgert, J.H.H.M. (author)Background The observed association between Depo-Provera injectable use and increased HIV acquisition may be caused by hormone-induced increased susceptibility to other sexually transmitted infections (STIs) or changes in the cervicovaginal microbiota (VMB), accompanied by genital immune activation and/or mucosal remodeling. Methods Rwandan...article 2015
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Simons, M. (author), Koopman, H. (author), Osinga, M. (author)Insulin requirement affects the careers of diabetic professionals who do safety-sensitive jobs. In most cases, insulin-treated individuals are automatically banned from safety-sensitive jobs because the risk of hypoglycaemia is regarded as incompatible with safety. Recent developments—such as diabetes self-management education, self-monitoring...article 2014
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Zeegers, M.P. (author), Nekeman, D. (author), Khan, H.S. (author), van Dijk, B.A.C. (author), Goldbohm, R.A. (author), Schalken, J. (author), Shajahan, S. (author), Pearlman, A. (author), Oddoux, C. (author), van den Brandt, P.A. (author), Schouten, L.J. (author), Ostrer, H. (author), TNO Preventie en Gezondheid (author)Background:Prostate cancer is the most commonly diagnosed cancer in men in Europe and the United States. Numerous studies have indicated genetics to have a major role in the aetiology of this disease; as much as 42% of the risk may be explained by heritable factors. Genome-wide association studies have detected an association between prostate...article 2013
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Heinen, M.M. (author), Verhage, B.A.J. (author), Goldbohm, R.A. (author), Lumey, L.H. (author), van den Brandt, P.A. (author)Background: Because of their influence on insulin concentrations, we hypothesized that both physical activity and energy restriction may reduce the risk of pancreatic cancer. Objective: We examined the associations between physical activity, proxies for energy restriction, and pancreatic cancer risk. Design: The Netherlands Cohort Study...article 2011
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Haas, F.J.L.M. (author), Schutgens, R.E.G. (author), Kluft, C. (author), Biesma, D.H. (author)Introduction. The exclusion of deep venous thrombosis (DVT) by pre-test probability (PTP) and D-dimer in the elderly is safe, but has a low specificity. There is increasing interest in the diagnostic role of thrombin generation in patients with thrombosis. We evaluated the value of thrombin generation in the exclusion of DVT, especially in...article 2011
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Schouten, L.J. (author), van Dijk, B.A.C. (author), Lumey, L. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author)Dietary energy restriction may protect against cancer. In parts of the Netherlands, mostly in larger cities, periods of chronically impaired nutrition and even severe famine (Hunger Winter 1944-1945) existed during the 1930s and World War II (1940-1945). We studied the association between energy restriction during childhood and early adulthood...article 2011
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Pedersen, G.S. (author), Hogervorst, J.G.F. (author), Schouten, L.J. (author), Konings, E.J.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Acrylamide, a potential human carcinogen, has been discovered in a variety of heat-treated carbohydrate-rich food products. Previously, dietary acrylamide intake was shown to be associated with endocrine-related cancers in humans. We assessed the association between dietary acrylamide intake and risk of postmenopausal breast cancer stratified by...article 2010
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Geert Heidema, A. (author), Thissen, U. (author), Boer, J.M.A. (author), Bouwman, F.G. (author), Feskens, E.J.M. (author), Mariman, E.C.M. (author), TNO Kwaliteit van Leven (author)In this study, we applied the multivariate statistical tool Partial Least Squares (PLS) to analyze the relative importance of 83 plasma proteins in relation to coronary heart disease (CHD) mortality and the intermediate end points body mass index, HDL-cholesterol and total cholesterol. From a Dutch monitoring project for cardiovascular disease...article 2009
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- Reijneveld, S.A. (author), de Meer, G. (author), Wiefferink, C.H. (author), Crone, M.R. (author), TNO Kwaliteit van Leven (author) article 2008
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Bongaerts, B.W.C. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), de Goeij, A.F.P.M. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. Analyses...article 2008
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Beulens, J.W.J. (author), de Zoete, E.C. (author), Kok, F.J. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)Objective: Moderate alcohol consumption is associated with a decreased risk of type II diabetes. This study investigates the effect of moderate alcohol consumption on adipokines and insulin sensitivity. Subjects: Twenty healthy, lean (body mass index (BMI) 18.5-25 kg/m2; n=11) or overweight (BMI>27 kg/m2; n=9) men (18-25 years). Methods: Three...article 2008
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Zaadstra, B.M. (author), Chorus, A.M.J. (author), van Buuren, S. (author), Kalsbeek, H. (author), van Noort, J.M. (author), TNO Defensie en Veiligheid TNO Kwaliteit van Leven (author), DenV KvL (author)Previous studies have suggested an association between multiple sclerosis (MS) and infectious mononucleosis (IM) but data on the exact strength of this association or its selectivity have been conflicting. In this study we have evaluated the association between MS and a variety of common childhood infections and afflictions in a large population...article 2008