Four-week oral toxicity study with erythritol in rats

Erythritol was orally administered to Wistar rats at dietary levels of 0, 5, and 10% for 4 weeks. Soft stools and diarrhea were observed in male and female animals of the 10% group and in female animals of the 5% group. These symptoms disappeared during the course of the study. Mean body weights of male rats in the high-dose group were...

Subchronic oral toxicity studies with erythritol in mice and rats

Erythritol is a sugar alcohol (polyol) with potential applications as a low-calorie, bulk sweetener. Ingested erythritol is efficiently absorbed and excreted unchanged via the urine since it is not metabolized systemically by the animal or human body. Erythritol was administered to four groups of 10 male and 10 female Swiss CD-1 mice and four...

Chronic (89-week) feeding study with hydroxypropyl distarch phosphate, starch acetate, lactose and sodium alginate in mice

The aetiology of caecal enlargement in the rat

The effect of hydroxypropyl starches (degree of substitution (DS) 0.025-0.106), lactose, raw potato starch, polyethylene glycol 1000 or magnesium sulphate on caecal size and some constituents of the caecal contents was studied in male rats of ages varying from 4 wk to 3 mth in experiments lasting from 10 days to 3 mth. All the test compounds...