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Wenczl, E. (author), Pool, S. (author), Timmerman, A.J. (author), van der Schans, G.P. (author), Roza, L. (author), Schothorst, A.A. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)An immunochemical assay, i.e. sandwich enzyme-linked immunosorbent assay, has been modified to detect UV-induced damage in cellular DNA of monolayer-grown human melanocytes. The method is based on the binding of a monoclonal antibody to single-stranded DNA. The melanocytes derived from human foreskin of skin type II individuals were suspended...article 1997
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Beekman, B. (author), Verzijl, N. (author), de Roos, J.A.D.M. (author), Koopman, J.L. (author), Tekoppele, J.M. (author), Leiden, Netherlands Gaubius Instituut TNO (author)Doxycycline is known for its ability to inhibit matrix metalloproteinases (MMPs), a family of enzymes that play a role in cartilage breakdown in arthritides. Its prophylactic effect in reducing joint degradation in osteoarthritis is mainly attributed to this property. In this study, we show that doxycycline exhibits a profound inhibition of...article 1997
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Visser, M.J.T. (author), van Lennep, A.C.D. (author), van Bockel, J.H. (author), van Hinsbergh, V.W.M. (author), van der Keur, M. (author), Hermans, J. (author), Gaubius Instituut TNO (author)For in vitro evaluation of functional properties of endothelial cells seeded on synthetic vascular prostheses accurate and reproducible quantification of cells is mandatory. Comparison of these properties with those resulting from other studies requires correlation of the functional parameters to reliably counted cell numbers. The accuracy of...article 1996
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- Wang, W. (author), Oppedijk, B.J. (author), Lu, X. (author), van Duijn, B. (author), Schilperoort, R.A. (author), TNO Voeding (author) article 1996
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- Rozing, J. (author), de Geus, B. (author), TNO Preventie en Gezondheid (author) article 1995
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- TNO Voeding (author), Sloot, W.N. (author) doctoral thesis 1995
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- Gezondheidsorganisatie TNO TNO Voeding Medisch Biologisch laboratorium TNO (author), de Raat, W.K. (author) doctoral thesis 1994
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- Centraal Instituut voor Voedingsonderzoek TNO (author), Jore, J. (author) doctoral thesis 1993
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- Geertman, E.J.M. (author) doctoral thesis 1992
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Centraal Instituut voor Voedingsonderzoek TNO (author), van Hengel, A.J. (author), Harkes, M.P. (author), Wichers, H.J. (author), Hesselink, P.G.M. (author), Buitelaar, R.M. (author)Camptotheca acuminata plants contain camptothecin which is a secondary metabolite with strong anti-tumor activity. The induction of callus and cell suspension cultures from Camptotheca acuminata stem parts on different media is described. Growth in the original media and in media with different salts and/or vitamins was followed by measuring...article 1992
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Instituut voor Experimentele Gerontologie TNO Institute of Ageing and Vascular Research TNO (author), Dobber, R. (author), Hertogh-Huijbregts, A. (author), Rozing, J. (author), Bottomly, K. (author), Nagelkerken, L. (author)It is well known that immune reactivity declines with age. Recently, we demonstrated that the age-related decrease in IL-2 production by CD4+ T cells was accompanied by an increased production of IL-4 and interferon-gamma (IFN-gamma). This age-related shift in the profile of lymphokine production was related to phenotypic changes within the CD4+...article 1992
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- Garbis-Berkvens, J.M. (author), Hofstee-Hooftman, M.W.A. (author), Verhoef, A. (author), Piersma, A.H. (author), Peters, P.W.J. (author), Koëter, H.B.W.M. (author) report 1991
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den Besten, C. (author), Smink, M.C.C. (author), de Vries, E.J. (author), van Bladeren, P.J. (author)Microsomal metabolism of (1,2,4-TrCB) and (PeCB) was studied with special emphasis on the conversion-dependent covalent binding to protein and DNA. 1,2,4-TrCB was metabolized to 2,3,6- and 2,4,5-trichlorophenol, and to a lesser extent to 2,4,6- and 2,3,5-trichlorophenol, and trichlorohydroquinone. About 10% of all metabolites became covalently...article 1991
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- Angelino, S.A.G.F. (author), Bol, J. (author) article 1990
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- Instituut CIVO-Toxicologie en voeding TNO (author), de Vos, R.H. (author) bookPart 1990
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- Centraal Instituut voor Voedingsonderzoek TNO (author), van der Plas, J. (author) doctoral thesis 1989
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- Nationale Raad voor Landbouwkundig Onderzoek (author) report 1989
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- Schönwalder, H. (author), Haaijman, J.J. (author), Holbrook, R. (author), Huis in 't Veld, J. (author), Notermans, S. (author), Schäffers, I.M. (author), Zschaler, R. (author) article 1988
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- Hartog, B.J. (author), Notermans, S. (author) bookPart 1988
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Rutten, A.A.J.J.L. (author), Jongen, W.M.F. (author), de Haan, L.H.J. (author), Hendriksen, E.G.J. (author), Koeman, J.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The dye-coupled intercellular communication across gap junctions in primary hamster tracheal epithelial cells has been studied in serum-free, hormone-supplemented medium. In the absence of vitamin A, non-cytotoxic concentrations of cigarette-smoke condensate (CSC) inhibited intercellular communication between tracheal epithelial cells in a...article 1988