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Tous, L. (author), Govaert, J. (author), Harrison, S. (author), Carrière, C. (author), Barth, V. (author), Giglia, V. (author), Buchholz, F. (author), Chen, N. (author), Halm, A. (author), Faes, A. (author), Nogay, G. (author), Quest, H. (author), Roessler, T. (author), Fellmeth, T. (author), Reinwand, D. (author), Stolzenburg, H. (author), Schindler, F. (author), Mittag, M. (author), Morlier, A. (author), Bokalic, M. (author), Brecl, K. (author), Kikelj, M. (author), Topic, M. (author), Kester, J.C.P. (author), Wendlandt, S. (author), Galiazzo, M. (author), Voltan, A. (author), Galbiati, G. (author), Ortiga, M.E. (author), Torregrosa, F. (author), Grimm, M. (author), Denafas, J. (author), Radavicius, T. (author), Lukinskas, P. (author), Savisalo, T. (author), Regrettier, T. (author), Gordon, I. (author)The EU crystalline silicon (c-Si) PV manufacturing industry has faced strong foreign competition in the last decade. To strive in this competitive environment and differentiate itself from the competition, the EU c-Si PV manufacturing industry needs to (1) focus on highly performing c-Si PV technologies, (2) include sustainability by design, and...article 2023
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Lozano-Ojalvo, D. (author), Benede, S. (author), Antunes, C.M. (author), Bavaro, S.L. (author), Bouchaud, G. (author), Costa, A. (author), Denery-Papini, S. (author), Diaz-Perales, A. (author), Garrido-Arandia, M. (author), Gavrovic-Jankulovic, M. (author), Hayen, S. (author), Martinez-Blanco, M. (author), Molina, E. (author), Monaci, L. (author), Pieters, R.H.H. (author), Villemin, C. (author), Wichers, H.J. (author), Wroblewska, B. (author), Willemsen, L.E.M. (author), Roggen, E.L. (author), van Bilsen, J.H.M. (author)Background: Before introducing proteins from new or alternative dietary sources into the market, a compressive risk assessment including food allergic sensitization should be carried out in order to ensure their safety. We have recently proposed the adverse outcome pathway (AOP) concept to structure the current mechanistic understanding of the...article 2019
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- MacDougall, P. (author), Ran, B. (author), Huitema, G.B. (author), Deconinck, G. (author) conference paper 2018
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- Ooi, H.W. (author), Mota, C. (author), ten Cate, T. (author), Calore, A. (author), Moroni, L. (author), Baker, M.B. (author) article 2018
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Laan, C.M. (author), Barros, A.I. (author), Boucherie, R.J. (author), Monsuur, H. (author)This paper considers a special case of security games dealing with the protection of a large area divided in multiple cells for a given planning period. An intruder decides on which cell to attack and an agent selects a patrol route visiting multiple cells from a finite set of patrol routes such that some given operational conditions on the...conference paper 2017
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Stegehuis, P.L. (author), Boogerd, L.S.F. (author), Inderson, A. (author), Veenendaal, R.A. (author), van Gerven, P. (author), Bonsing, B.A. (author), Sven Mieog, J. (author), Amelink, A. (author), Veselic, M. (author), Morreau, H. (author), van de Velde, C.J.H. (author), Lelieveldt, B.P.F. (author), Dijkstra, J. (author), Robinson, D.J. (author), Vahrmeijer, A.L. (author)Endoscopic ultrasound-guided fine needle aspirations (EUS-FNA) of pancreatic masses suffer from sample errors and low-negative predictive values. Fiber-optic spectroscopy in the visible to near-infrared wavelength spectrum can noninvasively extract physiological parameters from tissue and has the potential to guide the sampling process and...article 2017
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Sadeghian Marnani, H. (author), Paul, P.C. (author), Herfst, R.W. (author), Dekker, A. (author), Winters, J. (author), Maturova, K. (author)Scanning Probe microscope (SPM) is an important nanoinstrument for several applications such as bioresearch, metrology, inspection and nanopatterning. Single SPM is associated with relatively slow rate of scanning and low throughput measurement, thus not being suitable for scanning large samples such as semiconductor wafers and photolithography...conference paper 2017
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Martinez, A.M. (author), Trichias, K. (author), Litjens, R. (author)Active Antenna Systems (AAS) technology is one of several advanced features that enable a mobile network operator to cost-efficiently increase its network capacity to cope with the exponential mobile data traffic growth and the ever more demanding performance requirements. AAS can be exploited to perform e.g. Virtual Sectorisation (ViS), i.e....conference paper 2016
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Stegehuis, P.L. (author), Boogerd, L.S.F. (author), Inderson, A. (author), Veenendaal, R.A. (author), Bonsing, B.A. (author), Amelink, A. (author), Vahrmeijer, A.L. (author), Dijkstra, J. (author), Robinson, D.J. (author)EUS-FNA can be used for pathological confirmation of a suspicious pancreatic mass. However, performance depends on an on-site cytologist and time between punction and final pathology results can be long. SFR spectroscopy is capable of extracting biologically relevant parameters (e.g. oxygenation and blood volume) in real-time from a very small...conference paper 2016
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Hoffmann, H. (author), Ramachandra, P. (author), Kovacs, I.Z. (author), Jorguseski, L. (author), Gunnarsson, F. (author), Kurner, T. (author)In recent years Mobile Network Operators (MNOs) worldwide are extensively deploying LTE networks in different spectrum bands and utilising different bandwidth configurations. Initially, the deployment is coverage oriented with macro cells using the lower LTE spectrum bands. As the offered traffic (i.e. the requested traffic from the users)...article 2015
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Higuera, G.A. (author), Fernandes, H. (author), Spitters, T.W.G.M. (author), van de Peppel, J. (author), Aufferman, N. (author), Truckenmueller, R. (author), Stoop, R. (author), van Leeuwen, J.P. (author), de Boer, J. (author), Subramaniam, V. (author), Karperien, M. (author), van Blitterswijk, C. (author), van Boxtel, A. (author), Moroni, L. (author)Cells and tissues are intrinsically adapted to molecular gradients and use them to maintain or change their activity. The effect of such gradients is particularly important for cell populations that have an intrinsic capacity to differentiate into multiple cell lineages, such as bone marrow derived mesenchymal stromal cells (MSCs). Our results...article 2015
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Ramasamy, U.S. (author), Venema, K. (author), Schols, H.A. (author), Gruppen, H. (author)The aim of this research was to study the in vitro fermentation of chicory root pulp (CRP) and ensiled CRP (ECRP) using human fecal inoculum. Analysis of carbohydrate levels in fermentation digests showed that 51% of all CRP carbohydrates were utilized after 24 h of fermentation. For ECRP, having the same cell wall polysaccharide composition as...article 2014
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Chen, Y. (author), Sun, A. (author), Wang, M. (author), Zhu, Z. (author), Ouwerkerk, P.B.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Glutelins are the most abundant storage proteins in rice grain and can make up to 80 % of total protein content. The promoter region of GluB-1, one of the glutelin genes in rice, has been intensively used as a model to understand regulation of seed-storage protein accumulation. In this study, we describe a zinc finger gene of the Cys3His1 (CCCH...article 2014
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TNO Kwaliteit van Leven (author), Bijland, S. (author), Pieterman, E.J. (author), Maas, A.C.E. (author), van der Hoorn, J.W.A. (author), van Erk, M.J. (author), van Klinken, J.B. (author), Havekes, L.M. (author), van Dijk, K.W. (author), Princen, H.M.G. (author), Rensen, P.C.N. (author)The peroxisome proliferator-activated receptor alpha (PPARalpha) activator fenofibrate efficiently decreases plasma triglycerides (TG), which is generally attributed to enhanced very low density lipoprotein (VLDL)-TG clearance and decreased VLDL-TG production. However, because data on the effect of fenofibrate on VLDL production are...article 2010
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van Riet, E. (author), Everts, B. (author), Retra, K. (author), Phylipsen, M. (author), van Hellemond, J.J. (author), Tielens, A.G.M. (author), van der Kleij, D. (author), Hartgers, F.C. (author), Yazdanbakhsh, M. (author), TNO Defensie en Veiligheid (author)Background: Recognition of pathogens by dendritic cells (DCs) through interaction with pattern recognition receptors, including Toll like receptors (TLR), is crucial for the initiation of appropriate polarized T helper (Th) cell responses. Yet, the characteristics and differences in molecular profiles of DCs with different T cell polarizing...article 2009
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Hamer, H.M. (author), Jonkers, D.M.A.E. (author), Loof, A. (author), van Houtvin, S.A.L.W. (author), Troost, F.J. (author), Venema, K. (author), Kodde, A. (author), Koek, G.H. (author), Schipper, R.G. (author), van Heerde, W.L. (author), Brummer, R.J. (author), TNO Kwaliteit van Leven (author)Background: The mucus layer is an important dynamic component of the epithelial barrier. It contains mucin glycoproteins and other compounds secreted by the intestinal epithelium, such as secretory IgA. However, a standardized in vivo sampling technique of mucus in humans is not yet available. Aim: To assess the validity and feasibility of mucin...article 2009
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Liu, J. (author), O'Brien, K.L. (author), Lynch, D.M. (author), Simmons, N.L. (author), La Porte, A. (author), Riggs, A.M. (author), Abbink, P. (author), Coffey, R.T. (author), Grandpre, L.E. (author), Seaman, M.S. (author), Landucci, G. (author), Forthal, D.N. (author), Montefiori, D.C. (author), Carville, A. (author), Mansfield, K.G. (author), Havenga, M.J. (author), Pau, M.G. (author), Goudsmit, J. (author), Barouch, D.H. (author), TNO Kwaliteit van Leven (author)A recombinant adenovirus serotype 5 (rAd5) vector-based vaccine for HIV-1 has recently failed in a phase 2b efficacy study in humans. Consistent with these results, preclinical studies have demonstrated that rAd5 vectors expressing simian immunodeficiency virus (SIV) Gag failed to reduce peak or setpoint viral loads after SIV challenge of rhesus...article 2009
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Lu, Z.F. (author), Doulabi, B.Z. (author), Huang, C.L. (author), Bank, R.A. (author), Helder, M.N. (author), TNO Kwaliteit van Leven (author)β1 integrins play a controversial role during chondrogenesis. Since the maturation of chondrocytes relies on a signaling switch from cell-cell to cell-matrix interactions, we hypothesized that β1 integrins play a different role at the earlier (mainly cell-cell interaction) from the later stage (mainly cell-matrix interaction) of chondrogenesis....article 2008
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de Ruiter, M.C. (author), Alkemade, F.E. (author), de Gittenberger - Groot, A.C. (author), Poelmann, R.E. (author), Havekes, L.M. (author), van Dijk, K.W. (author), TNO Kwaliteit van Leven (author)In this review, we briefly summarize the possible signals crossing the placental barrier and discuss the molecular mechanisms of epigenetic programming in the developing fetus leading to increased athero-susceptibility of the vessel wall. © 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.article 2008
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Henneman, S. (author), Bildt, M.M. (author), de Groot, J. (author), Kuijpers-Jagtman, A.M. (author), Von den Hoff, J.W. (author)The main cells in the periodontal ligament (PDL) are the fibroblasts, which play an important role in periodontal remodelling. Matrix metalloproteinases (MMPs) are largely responsible for the degradation of extracellular matrix proteins in the PDL. Previous studies have indicated that MMP production can be stimulated by the hormone relaxin. This...article 2008