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van Gorcom, R.F.M. (author), Boschloo, J.G. (author), Kuijvenhoven, A. (author), Lange, J. (author), van Vark, A.J. (author), Bos, C.J. (author), van Balken, J.A.M. (author), Pouwels, P.H. (author), van den Hondel, C.A.M.J.J. (author)
The gene coding for benzoate-para-hydroxylase (bphA) of Aspergillus niger was cloned using differential hybridisation techniques and complementation of mutants deficient in this enzyme activity. The nucleotide sequence of the gene was determined, the presence of two introns was shown and the transcription start and termination sites were...
article 1990
Instituut CIVO-Toxicologie en Voeding TNO (author), van Ommen, B. (author), Hendriks, W. (author), Bessems, J.G.M. (author), Geesink, G. (author), Muller, F. (author), van Bladeren, P.J. (author)
The relation between the major toxic effect of hexachlorobenzene, hepatic porphyria, and its oxidative biotransformation was studied in vivo, by observing the effect of modulating its biotransformation on the expression of porphyria. This modulation was achieved by selective in vivo inhibition of the major cytochrome P450 isoenzyme involved in...
article 1989