Searched for: subject%3A%22cyclic%255C%2BAMP%22
(1 - 19 of 19)
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Boon, M.R. (author), Kooijman, S. (author), van Dam, A.D. (author), Pelgrom, L.R. (author), Berbée, J.F.P. (author), Visseren, C.A.R. (author), van Aggele, R.C. (author), van den Hoek, A.M. (author), Sips, H.C.M. (author), Lombès, M. (author), Havekes, L.M. (author), Tamsma, J.T. (author), Guigas, B. (author), Meijer, O.C. (author), Jukema, J.W. (author), Rensen, P.C.N. (author)
The endocannabinoid system is an important player in energy metabolism by regulating appetite, lipolysis, and energy expenditure. Chronic blockade of the cannabinoid 1 receptor (CB1R) leads to long-term maintenance of weight loss and reduction of dyslipidemia in experimental and human obesity. The molecular mechanism by which CB1R blockade...
article 2014
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Gaubius Instituut TNO (author), Coomans, C.P. (author), Geerling, J.J. (author), Guigas, B. (author), van den Hoek, A.M. (author), Parlevliet, E.T. (author), Ouwens, D.M. (author), Pijl, H. (author), Voshol, P.J. (author), Rensen, P.C.N. (author), Havekes, L.M. (author), Romijn, J.A. (author)
Insulin signaling in the central nervous system (CNS) is required for the inhibitory effect of insulin on glucose production. Our aim was to determine whether the CNS is also involved in the stimulatory effect of circulating insulin on the tissue-specific retention of fatty acid (FA) from plasma. In wild-type mice, hyperinsulinemic-euglycemic...
article 2011
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de Leeuw van Weenen, J.E. (author), Parlevliet, E.T. (author), Maechler, P. (author), Havekes, L.M. (author), Romijn, J.A. (author), Ouwens, D.M. (author), Pijl, H. (author), Guigas, B. (author), TNO Kwaliteit van Leven (author)
Treatment with the dopamine receptor D2 (DRD2) agonist bromocriptine improves metabolic features in obese patients with type 2 diabetes by a still unknown mechanism. In the present study, we investigated the acute effect of bromocriptine and its underlying mechanism(s) on insulin secretion both in vivo and in vitro. For this purpose, C57Bl6/J...
article 2010
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TNO Kwaliteit van Leven (author), Madsen, L. (author), Pedersen, L.M. (author), Liaset, B. (author), Ma, T. (author), Petersen, R.K. (author), van den Berg, S. (author), Pan, J. (author), Müller-Decker, K.M. (author), Dülsner, E.D. (author), Kleemann, R. (author), Kooistra, T. (author), Døskeland, S.O. (author), Kristiansen, K. (author)
The effect of n-6 polyunsaturated fatty acids (n-6 PUFAs) on adipogenesis and obesity is controversial. Using in vitro cell culture models, we show that n-6 PUFAs was pro-adipogenic under conditions with base-line levels of cAMP, but anti-adipogenic when the levels of cAMP were elevated. The anti-adipogenic action of n-6 PUFAs was dependent on a...
article 2008
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Verhoeckx, K.C.M. (author), Korthout, H.A.A.J. (author), van Meeteren-Kreikamp, A.P. (author), Ehlert, K.A. (author), Wang, M. (author), van der Greef, J. (author), Rodenburg, R.J.T. (author), Witkamp, R.F. (author), TNO Kwaliteit van Leven (author)
There is a great interest in the pharmacological properties of cannabinoid like compounds that are not linked to the adverse effects of Δ9-tetrahydrocannabinol (THC), e.g. psychoactive properties. The present paper describes the potential immuno-modulating activity of unheated Cannabis sativa extracts and its main non-psychoactive constituent Δ9...
article 2006
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Verhoeckx, K.C.M. (author), Doornbos, R.P. (author), Witkamp, R.F. (author), van der Greef, J. (author), Rodenburg, R.J.T. (author), TNO Kwaliteit van Leven (author)
Vascular endothelial growth factor (VEGF), oncostatin M (OSM), and granulocyte chemotactic protein-2 (GCP-2/CXCL6) are up-regulated in U937 macrophages and peripheral blood macrophages exposed to LPS, beta-adrenergic receptor (β2-AR) agonists (e.g. zilpaterol, and clenbuterol) and some other agents that induce intracellular cAMP (prostaglandin...
article 2006
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Verhoeckx, K.C.M. (author), Gaspari, M. (author), Bijlsma, S. (author), van der Greef, J. (author), Witkamp, R.F. (author), Doornbos, R.P. (author), Rodenburg, R.J.T. (author), TNO Kwaliteit van Leven (author)
Two-dimensional difference gel electrophoresis (DIGE) in combination with univariate (Student's t-test) and multivariate data analysis, principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were used to study the anti-inflammatory effects of the β2-adrenergic receptor (β2-AR) agonist zilpaterol. U937...
article 2005
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Verhoeckx, K.C.M. (author), Doornbos, R.P. (author), van der Greef, J. (author), Witkamp, R.F. (author), Rodenburg, R.J.T. (author), TNO Kwaliteit van Leven (author)
In this study the anti-inflammatory properties of zilpaterol, a β2-adrenergic receptor (AR) agonist specifically developed as a growth promoter in cattle were investigated. Although zilpaterol has a different structure compared with the β2-AR agonists known to date, it was noted that it was able to bind to both the β2-AR (K i = 1.1 × 10-6) and...
article 2005
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Izeboud, C.A. (author), Vermeulen, R.M. (author), Zwart, A. (author), Vos, H.P. (author), van Miert, A.S.J.P.A.M. (author), Witkamp, R.F. (author)
Previous research has shown that β-adrenoceptor (β-AR) agonists have potent anti-inflammatory capabilities, e.g. represented by suppression of release of the proinflammatory cytokines. Aim of this research was to determine whether the effects of β-agonists on LPS-induced TNFα and IL-10 release are influenced by their different stereochemistry....
article 2000
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van Nieuw Amerongen, G.P. (author), Vermeer, M.A. (author), van Hinsbergh, V.W. (author), Gaubius Instituut TNO (author)
In the present study, the roles of the small GTPase RhoA and its target Rho kinase in endothelial permeability were investigated in vitro. We have shown previously that, in addition to a rise in the intracellular Ca(2+) concentration ([Ca(2+)](i)), RhoA is involved in the prolonged thrombin-induced barrier dysfunction. To study the role of RhoA...
article 2000
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Hegeman, R.J. (author), van den Eijnden-Schrauwen, Y. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
The effect of compounds increasing intracellular adenosine 3':5'cyclic monophosphate [cAMP](i) levels (prostacyclin. isoproterenol, forskolin, cholera toxin), and of the cAMP analogs 8-bromo-cAMP and dibutyrpl-cAMP, on the regulated secretion (acute release) of tissue-type plasminogen activator (tPA) and von Willebrand factor (vWF) was studied...
article 1998
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Emeis, J.J. (author), van den Hoogen, C.M. (author), Diglio, C.A. (author), Gaubius Instituut TNO (author)
The synthesis, storage and regulated secretion (acute release) of tissue-type plasminogen activator (tPA) were studied in cultured rat heart endothelial (RHE) cells. In this study, special attention was paid to the correspondence between tPA metabolism in RHE cells in vitro and tPA metabolism in rats in vivo. RHE cells synthetized tPA, as shown...
article 1998
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van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
article 1997
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), Evers, R. (author), Cnubben, N.H.P. (author), Wijnholds, J. (author), van Deemter, L. (author), van Bladeren, P.J. (author), Borst, P. (author)
The human multidrug resistance protein MRP1 mediates transport of organic substrates conjugated to glutathione, glucuronide, or sulfate. The naturally occurring prostaglandins A1 and A2 can form two diastereomeric glutathione S-conjugates, and it has been speculated that these might be substrates for MRP1. Here we present evidence that polarized...
article 1997
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Kooistra, T. (author), Lansink, M. (author), Emeis, J.J. (author), TNO Preventie en Gezondheid (author)
Chemicals/CAS: 4 [2 (5,6,7,8 tetrahydro 5,5,8,8 tetramethyl 2 naphthyl) 1 propenyl]benzoic acid, 71441-28-6; butyric acid, 107-92-6, 156-54-7, 461-55-2; cyclic AMP, 60-92-4; protein kinase C, 141436-78-4; retinoic acid, 302-79-4; tissue plasminogen activator, 105913-11-9; trichostatin A, 58880-19-6
article 1996
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Draijer, R. (author), Atsma, D.E. (author), van der Laarse, A. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
Previous studies have demonstrated that cGMP and cAMP reduce the endothelial permeability for fluids and macromolecules when the endothelial permeability is increased by thrombin. In this study, we have investigated the mechanism by which cGMP improves the endothelial barrier function and examined whether nitric oxide (NO) can serve as an...
article 1995
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Tranquille, N. (author), Emeis, J.J. (author), Gaubius Laboratory Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
The modulation of the induced acute release of tissue-type plasminogen activator (t-PA) and of von Willebrand factor (vWF) by compounds affecting cyclic nucleotide levels was studied, using an isolated rat hindleg perfusion system. Platelet-activating factor (PAF; 5 nM) or bradykinin (0.8 μM) were used to induce release of t-PA and vWF. The...
article 1993
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Emeis, J.J. (author), Tranquille, N. (author), Gaubius Instituut TNO (author)
Bradykinin will induce, in perfused rat hindlegs, the acute release from endothelial cells of tissue-type plasminogen activator and of von Willebrand factor. This release is mediated by B2-receptors, requires the influx of extracellular calcium, and is modulated by cyclic nucleotides. A possible role of bradykinin in the physiological regulation...
article 1992
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Gaubius instituut TNO (author), Kooistra, T. (author), van den Berg, J. (author), Tons, A. (author), Platenburg, G. (author), Rijken, D.C. (author), van den Berg, E.A. (author)
Incubation of cultured human endothelial cells with 5-mM-dibutyryl cyclic AMP led to an approx. 2-fold increase in tissue-type plasminogen-activator (t-PA) production over a 24 h incubation period. The stimulating effect of dibutyryl cyclic AMP could be explained by the slow liberation of butyrate, as the effect could be reproduced by addition...
article 1987
Searched for: subject%3A%22cyclic%255C%2BAMP%22
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