Searched for: subject:"controlled%5C+study"
(1 - 20 of 1,610)

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Wolthuis, O.L. (author), Benschop, H.P. (author), Berends, F. (author), Medisch Biologisch Laboratorium TNO (author)
Anaesthetized, atropinized rats were posioned with 6x LD50 soman (1,2,2-trimethylpropyl methylphosphonofluoridate). Purified acetylcholinesterase, injected i.v. 75 min later, was rapidly inhibited, presumably by soman stored in a 'depot' from which it was gradually released. Existence of a depot is supported by the effect of a soman-simulator (...
article 1981
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Kempen, H.J.M. (author), van Vos-Holstein, P.M. (author), de Lange, J. (author), Gaubius instituut TNO (author)
Contents of bile acids and lipids, as well as rates of triglyceride synthesis, were determined in isolated hepatocytes from control or cholestyramine-fed rats (denoted below as "control" or "treated" hepatocytes, respectively). During a 3-hr incubation period, total bile acid production was markedly higher in "treated" cells than in "conrol"...
article 1982
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Reynders, J.B.J. (author), Immel, H.R. (author), Scherrenberg, P.M. (author), Feron, V.J. (author), Beems, R.B. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Two groups of male and female Syrian golden hamsters, of which the trachea was severely injured by electrocoagulation, received 6 weekly intratracheal instillations of benzo[a]pyrene (BaP) + ferric oxide in saline or saline alone. Two comparable groups of hamsters were similarly treated but had an undamaged trachea. The experiment was terminated...
article 1985
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van den Berg, H. (author), Louwerse, E.S. (author), Bruinse, H.W. (author), Thissen, J.T.N.M. (author), Schrijver, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The vitamin B6 status of women suffering from premenstrual symptoms (PMS, n = 19) and a group of matched controls (n = 19) has been investigated. The women volunteering in the study were selected on strictly defined criteria. Several biochemical parameters of the metabolism of vitamin B6 and tryptophan were studied in blood and urine samples...
article 1986
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Riemersma, J.B.J. (author), Instituut voor Zintuigfysiologie TNO (author)
Driver behaviour will partially be a function of the cognitive schemata by which drivers represent features, functions and operations of traffic system components. This paper uses the Repertory Grid Technique to address the questions: (1) How do drivers internally represent different categories of road? (2) How are those representations mapped...
article 1988
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Godthelp, J. (author), Käppler, W.D. (author), Instituut voor Zintuigfysiologie TNO (author)
The time-to-line-crossing (TLC) concept has been used as a time-related measure to describe driving strategy. The purpose of this research is to analyze whether TLC might enlarge our understanding of the relationship between vehicle handling characteristics and a driver's looking and lateral control strategy in a straight-lane-keeping task....
article 1988
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Lotens, W.A. (author), Instituut voor Zintuigfysiologie TNO (author)
The effect of geometric factors on insulation was calculated mathematically for standing humans. It was found that internal radiative heat transfer in an ensemble was significant for insulation, that intrinsic clothing insulation is a useful concept only for indoor climates, and that shape plays a minor role. The literature agrees closely on...
article 1989
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van 't Veer, P. (author), Dekker, J.M. (author), Lamers, J.W.J. (author), Kok, F.J. (author), Schouten, E.G. (author), Brants, H.A.M. (author), Sturmans, F. (author), Hermus, R.J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In a case-control study in The Netherlands, we observed a significantly lower consumption of fermented milk products (predominantly yogurt and buttermilk) among 133 incident breast cancer cases as compared to 289 population controls (mean ± SD among users only, 116 ± 100 versus 157 ± 144 g/day; P<0.01). The age-adjusted odds ratio of daily...
article 1989
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Theeuwes, J. (author), Instituut voor Zintuigfysiologie TNO (author)
Two experiments were conducted which tested the effect of two different types of cues on the allocation of attention in the visual field. Subjects responded to a target appearing either 6.5° to the right or to the left of fixation in a field with small randomly positioned line segments. The target form was either a circle or diamond in which a...
article 1989
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Odink, J. (author), Kramer, F.M. (author), van der Beek, E.J. (author), Thissen, J.T.N.M. (author), Kempen, H.J.M. (author), van den Berg, H. (author), Egger, R.J. (author), Wientjes, C.J.E. (author), CIVO-TNO Nederlands instituut voor praeventieve gezondheidszorg TNO, NIPG-TNO Gaubius instituut TNO, GI-TNO Instituut voor zintuigfysiologie TNO, IZF-TNO (author)
This study was designed to investigate the relation between fatty acid consumption, total plama cholesterol and neuroendocrine response to exposure to stress, factors thought to play a role in the development of coronary heart disease. For this purpose 32 apparently healthy male volunteers were classified on the basis of their plasma cholesterol...
article 1989
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Emeis, J.J. (author), van Houwelingen, A.C. (author), van den Hoogen, C.M. (author), Hornstra, G. (author), Gaubius Institute TNO, 2300 AP Leiden, Netherlands (author)
For a period of 6 weeks, 76 healthy male volunteers consumed during their daily main meal the contents of one tin (~ 135 g) of either fish (mackerel) paste or meat paste. Fibrinolytic parameters were determined in plasma samples obtained at the beginning and at the end of the experimental period. No changes were found in plasminogen, α2...
article 1989
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Huisman, J. (author), van der Poel, A.F.B. (author), van Leeuwen, P. (author), Verstegen, M.W.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The effects of lectins in the diet have been mainly studied in rats. An important question is whether results obtained in rats can be extrapolated to larger animals like the pig. Phaseolus vulgaris beans are rich in toxic lectins. Therefore a study was carried out to compare the effects of diets containing 200 g Phaseolus vulgaris beans (raw or...
article 1990
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Havenith, G. (author), Heus, R. (author), Lotens, W.A. (author)
The individual and combined effects of sitting, walking at two speeds and three wind speeds on the insulation value of three clothing ensembles were determined on four subjects (two with loose clothing fit and two with tight clothing fit). Subjects were wrapped in synthetic foil before dressing in order to avoid sweat evaporation and so increase...
article 1990
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Holewijn, M. (author)
In an experimental study of load carrying the effects of mass (0, 5.4, 10.4 kg) and the type of support (on the shoulder or on waist) on parameters of physiological strain were quantified to determine the factor(s) which limit carrying time. Four categories of strain were investigated: metabolic (in terms of oxygen uptake), cardiovascular (in...
article 1990
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van 't Veer, P. (author), van der Wielen, R.P.J. (author), Kok, F.J. (author), Hermus, R.J.J. (author), Sturmans, F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The association between breast cancer and selenium, measured in the diet, plasma, erythrocytes, and toenails, was investigated in a case-control study in the Netherlands during 1985-1987. Dietary selenium intake was assessed by a structured dietary history technique among 133 breast cancer cases and 238 population controls. Absolute and energy...
article 1990
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Wertheim, A.H. (author), van Gelder, P. (author)
When the eyes pursue a fixation point that sweeps across a moving background pattern, and the fixation point is suddenly made to stop, the ongoing motion of the background pattern seems to accelerate to a higher velocity. Experiment I showed that this acceleration illusion is not caused by the sudden change in (i) the relative velocity between...
article 1990
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van 't Veer, P. (author), van Leer, E.M. (author), Rietdijk, A. (author), Kok, F.J. (author), Schouten, E.G. (author), Hermus, R.J.J. (author), Sturmans, F. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Combinations of dietary factors were studied in relation to breast-cancer occurrence among 133 breast cancer cases and 289 population controls in The Netherlands. Dietary factors were classified according to their possible mechanism of action, i.e., relating either to the intestinal microflora (total fat, fiber, fermented milk products) or to...
article 1991
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Gijbels, M.J.J. (author), Visser, J.W.M. (author), Solleveld, H.A. (author), Broerse, J.J. (author), Zurcher, C. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
Archival paraffin embedded material was used to examine whether additional quantitative criteria would be helpful to discriminate between histologically benign and malignant rat mammary tumours. To this end nuclear DNA content expressed as DNA ploidy index (DI) was measured using flow cytometry (FCM). A total of 63 benign and malignant mammary...
article 1991
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Wolthuis, O.L. (author), Philippens, I.H.C.H.M. (author), Vanwersch, R.A.P. (author), Medisch Biologisch Laboratorium TNO (author), MBL (author)
Several earlier studies showed that, in contrast with DFP, repeated injections with soman did not lead to behavioral tolerance in rats. The reason for the difference between the effects of these two organophosphate cholinesterase inhibitors was not clear and a neurophysiological approach was undertaken. Four experiments (A, B, C and D) were...
article 1991
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Korteling, J.E. (author)
Age-related differences in dual-task performance may be affected by factors such as skill integration and perceptual competition. Therefore these factors were examined in a dual-task experiment with young and older adults involving two one-dimensional compensatory tracking tasks. Single-task difficulty was individually adjusted for each subject....
article 1991
Searched for: subject:"controlled%5C+study"
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