Searched for: subject:"controlled%5C+clinical%5C+trial"
(1 - 20 of 158)

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Havermans, B.M. (author), Boot, C.R.L. (author), Brouwers, E.P.M. (author), Houtman, I.L.D. (author), Anema, J.R. (author), van der Beek, A.J. (author)
Objective: The objective was to evaluate the process and feasibility of a digital platform-based implementation strategy aimed at work stress prevention. Methods: The process evaluation was performed alongside a controlled trial within a health care organization, in the experimental group (N = 221). Mental models, context, and barriers and...
article 2018
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Boesveld, I.C. (author), Bruijnzeels, M.A. (author), Hitzert, M. (author), Hermus, M.A.A. (author), van der Pal-de Bruin, K.M. (author), van den Akker-van Marle, M.E. (author), Steegers, E.A.P. (author), Franx, A. (author), de Vries, R.G. (author), Wiegers, T.A. (author)
Background: The goal of integrated care is to offer a continuum of care that crosses the boundaries of public health, primary, secondary, and tertiary care. Integrated care is increasingly promoted for people with complex needs and has also recently been promoted in maternity care systems to improve the quality of care. Especially when located...
article 2017
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van den Broek, T.J. (author), Bakker, G.C.M. (author), Rubingh, C.M. (author), Bijlsma, S. (author), Stroeve, J.H.M. (author), van Ommen, B. (author), van Erk, M.J. (author), Wopereis, S. (author)
Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. A systemic review defined an optimal nutritional challenge test, the "PhenFlex test" (PFT). Recently, it has been shown that the PFT enables the quantification of all relevant metabolic processes involved in maintaining or regaining homeostasis of...
article 2017
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Kocken, P.L. (author), Scholten, A.M. (author), Westhoff, E. (author), Kok, B.P.H. (author), Taal, E.M. (author), Goldbohm, R.A. (author)
The effectiveness of the “Extra Fit!” (EF!) education program in promoting healthy diet and physical activity to prevent and reduce overweightness among primary school children aged 9 to 11 was evaluated. A randomized controlled design was carried out in 45 primary schools (n = 1112) in the Netherlands, 23 intervention and 22 control schools....
article 2016
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de Lijster, G.P.A. (author), Felten, H. (author), Kok, G. (author), Kocken, P.L. (author)
Many adolescents experience sexual harassment and victims of sexual harassment have higher risks regarding well-being and health behaviors such as higher risks of suicidal thoughts, suicidal ideation and feeling unsafe at school. A peer-performed play and school lessons on preventing sexual harassment behavior were presented to secondary school...
article 2016
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van Laethem, M. (author), Beckers, D.G.J. (author), Kompier, M.A.J. (author), Kecklund, G. (author), van den Bossche, S.N.J. (author), Geurts, S.A.E. (author)
Objective In this longitudinal two-wave study, bidirectional relations between work-related stress and sleep quality were examined. Moreover, it was investigated whether perseverative cognition is a potential underlying mechanism in this association, related to both work-related stress and sleep quality. Methods A randomly selected sample of...
article 2015
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Levels, K. (author), de Koning, J.J. (author), Mol, E. (author), Foster, C. (author), Daanen, H.A.M. (author)
This study examined the effect of active pre-warming on speed and quality of performance during simulated firefighting exercise. Twelve male firefighters performed two trials in counterbalanced order. They were either pre-warmed by 20-min cycling at 1.5 Watt kg-1 body mass (WARM) or remained thermoneutral (CON) prior to a simulated firefighting...
article 2014
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Bakker, G.C.M. (author), van Erk, M.J. (author), Pellis, L. (author), Wopereis, S. (author), Rubingh, C.M. (author), Cnubben, N.H.P. (author), Kooistra, T. (author), van Ommen, B. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Background: Low-grade chronic inflammation in overweight subjects is thought to play an important role in disease development. Objective: It was hypothesized that specific dietary components are able to reduce low-grade inflammation as well as metabolic and oxidative stress. Design: Dietary products [resveratrol, green tea extract, α-tocopherol,...
article 2010
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Hamer, H.M. (author), Jonkers, D.M.A.E. (author), Renes, I.B. (author), Vanhoutvin, S.A.L.W. (author), Kodde, A. (author), Troost, F.J. (author), Venema, K. (author), Brummer, R.-J.M. (author), TNO Kwaliteit van Leven (author)
INTRODUCTION: The colonic mucus layer plays an important role in the protection of the intestinal epithelium and mainly consists of mucin glycoproteins (primarily MUC2 in the colon) trefoil factor 3 (TFF3) and secretory IgA. Butyrate is a major end product of fermentation of dietary fibres and is associated with beneficial effects on colonic...
article 2010
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Hogenkamp, P.S. (author), Mars, M. (author), Stafleu, A. (author), de Graaf, C. (author), TNO Kwaliteit van Leven (author)
Background: An important question in the regulation of energy intake is whether dietary learning of energy content depends on the food's characteristics, such as texture. Texture might affect the duration of sensory exposure and eating rate. Objective: The objective was to investigate whether a long sensory exposure, due to differences in means...
article 2010
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Tak, P.P. (author), van Kuijk, A.W.R. (author), de Groot, J. (author), Koeman, R.C. (author), Sakkee, N. (author), Baeten, D.L. (author), Gerlag, D.M. (author), TNO Kwaliteit van Leven (author)
Background: There is growing interest in soluble biomarkers that could be used on the group level for screening purposes in small proof of principle studies during early drug development. We investigated early changes in serum levels of several candidate biomarkers involved in cartilage and bone metabolism following the initiation of adalimumab...
article 2010
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Ceconi, C. (author), Fox, K.M. (author), Remme, W.J. (author), Simoons, M.L. (author), Deckers, J.W. (author), Bertrand, M. (author), Parrinello, G. (author), Kluft, C. (author), Blann, A. (author), Cokkinos, D. (author), Ferrari, R. (author), TNO Kwaliteit van Leven (author)
The PERTINENT study measured biomarkers of atherosclerosis and thrombosis in a stable coronary artery disease population from EUROPA receiving ACE inhibition with perindopril 8 mg/day or placebo. Biomarkers of inflammation, C-reactive protein (CRP), fibrinogen, and tumor necrosis factor-alpha (TNF-α), and a biomarker of thrombosis, d-dimer, were...
article 2009
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van Peppen, R.P.S. (author), Schuurmans, M.J. (author), Stutterheim, E.C. (author), Lindeman, E. (author), van Meeteren, N.L.U. (author), TNO Kwaliteit van Leven (author)
Objective: To determine the influence of tutor expertise on the uptake of a physiotherapists' educational programme intended to promote the use of outcome measures in the management of patients with stroke. Design: Pilot randomized controlled trial. Methods: Thirty physiotherapists involved in stroke management were randomized into two groups...
article 2009
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Zijlstra, N. (author), de Wijk, R.A. (author), Mars, M. (author), Stafleu, A. (author), de Graaf, C. (author), TNO Kwaliteit van Leven (author)
article 2009
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van Dommelen, P. (author), Kamphuis, M. (author), van Leerdam, F.J.M. (author), de Wilde, J.A. (author), Rijpstra, A. (author), Campagne, A.E. (author), Verkerk, P.H. (author), TNO Kwaliteit van Leven (author)
Objective: To assess the short- and long-term effects of 3 simple behavioral interventions to overcome nocturnal enuresis in young children. Study design: We performed a randomized controlled trial in children aged four to five years with mono-symptomatic nocturnal enuresis (n = 570). The children were placed in one of four groups: (1) lifting...
article 2009
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Hellgren, M. (author), Conard, J. (author), Norris, L. (author), Kluft, C. (author), TNO Kwaliteit van Leven (author)
Objective: To study cardiovascular risk markers in women taking estradiol/trimegestone or estradiol/dydrogesterone. Design: Multicenter, randomized, prospective, double-blind study of 184 healthy post-menopausal women randomized to 6 cycles of either estradiol (2 mg) + trimegestone (0.5 mg) (T-group) or estradiol (2 mg) + dydrogesterone (10 mg) ...
article 2009
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Abdul-Hussien, H. (author), Hanemaaijer, R. (author), Verheijen, J.H. (author), van Bockel, J.H. (author), Geelkerken, R.H. (author), Lindeman, J.H.N. (author), TNO Kwaliteit van Leven (author)
Background: Matrix metalloproteinase-9 (MMP-9) is thought to play a central role in abdominal aortic aneurysm (AAA) initiation. Doxycycline, a tetracycline analogue, has direct MMP-9-inhibiting properties in vitro, and it effectively suppresses AAA development in rodents. Observed inhibition of AAA progression, and contradictory findings in...
article 2009
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Kersten, S. (author), Lichtenstein, L. (author), Steenbergen, E. (author), Mudde, K. (author), Hendriks, H.F.J. (author), Hesselink, M.K. (author), Schrauwen, P. (author), Müller, M. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE-: Plasma lipoprotein levels are determined by the balance between lipoprotein production and clearance. Recently, angiopoietin-like protein 4 (ANGPTL4) was uncovered as a novel endocrine factor that potently raises plasma triglyceride levels by inhibiting triglyceride clearance. However, very little is known about ANGPTL4 in human....
article 2009
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van den Heuvel, E.G.H.M. (author), Muijs, T. (author), Brouns, F. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Consumption of fructo-oligosaccharides (FOS) has been shown to improve mineral absorption in the short term, but no long-term effects were studied in girls with a low calcium intake. Therefore, we hypothesized that short- and long-term consumption of short-chain FOS (sc-FOS) improves calcium and magnesium absorption in girls with a low habitual...
article 2009
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van Wier, M.F. (author), Arins, G.A.M. (author), Dekkers, J.C. (author), Hendriksen, I.J.M. (author), Smid, T. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)
Background. The work setting provides an opportunity to introduce overweight (i.e., Body Mass Index 25 kg/m2) adults to a weight management programme, but new approaches are needed in this setting. The main purpose of this study was to investigate the effectiveness of lifestyle counselling by phone or e-mail on body weight, in an overweight...
article 2009
Searched for: subject:"controlled%5C+clinical%5C+trial"
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