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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), Löwik, M.R.H. (author), Hulshof, K.F.A.M. (author), Brussaard, J.H. (author)Dietary intake characteristics were studied among 3833 adults of the second Dutch National Food Consumption Survey held in 1992. The subjects were classified into three groups based on their intake of total fat (% energy), saturated fatty acids (% energy), dietary fibre (g/MJ), and fruit and vegetables (g/d). All the classifications resulted in...article 1999
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Feron, V.J. (author), Cassee, F.R. (author), Groten, J.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)This paper reviews major activities outside the United States on human health issues related to chemical mixtures. In Europe an international study group on combination effects has been formed and has started by defining synergism and antagonism. Successful research programs in Europe include the development and application of statistically...article 1998
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Goldbohm, R.A. (author), Brants, H.A.M. (author), Hulshof, K.F.A.M. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)This study presents data on dietary intake of specific carotenoids in the Netherlands, based on a recently developed food composition database for carotenoids. Regularly eaten vegetables, the main dietary source of carotenoids, were sampled comprehensively and analysed with modern analytic methods. The database was complemented with data from...article 1998
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Bast, A. (author), Haenen, G.R.M.M. (author), van den Berg, R. (author), van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Surprisingly, neither the precise pharmacological effect nor the toxicological profile is usually established for food components. Carotenoids are no exception in this regard. Only limited insight into the pharmacology and toxicology of carotenoids exists. It is known that the antioxidant action of carotenoids is determined by 1. electron...article 1998
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Rulkens, W.H. (author), Bruning, H. (author), van Hasselt, H.J. (author), Rienks, J. (author), van Veen, H.J. (author), Terlingen, J.P.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Solvent extraction is one of the possibilities to clean-up polluted sediments. It is especially attractive when the sediment mainly consists of clay particles polluted with contaminants which are not, or not easily, biodegradable. Using acetone as extracting agent the extraction process has been investigated at laboratory scale for treating...conference paper 1998
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van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Carotenoid interactions during absorption anti in postabsorptive metabolism have been observed in both human and animal studies. We reviewed the mutual interactions reported between lutein and β-carotene and report new data on the postprandial β-carotene and retinyl ester response in the triglyceride-rich plasma lipoprotein (TRL) fraction in...article 1998
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Elliott, C.T. (author), Baxter, G.A. (author), Hewitt, S.A. (author), Arts, C.J.M. (author), van Baak, M. (author), Hellenäs, K.-E. (author), Johannson, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The drug salbutamol (SBL) is a β-agonist that may be used illegally as an animal growth promoter. SBL is also a good example of a drug which is excreted in the form of glucuronides and sulfates. Such metabolites cause complexities in analysing for the presence of drug residues. In the majority of cases a process of deconjugation and sample clean...article 1998
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- Notermans, S. (author), Batt, C.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) article 1998
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Cellular target of UVB-induced DNA damage resulting in local suppression of contact hypersensitivityVink, A.A. (author), Shreedhar, V. (author), Roza, L. (author), Krutmann, J. (author), Kripke, M.L. (author)Experimental data are reviewed that lend support to the hypothesis that formation of DNA damage is the initiation event of local suppression of contact hypersensitivity (CHS) after exposure to ultraviolet (UV) radiaton and that the antigen-presenting cell (APC) is an important traget for this DNA damage. Chemicals/CAS: DNA, 9007-49-2article 1998
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Maassen, C.B.M. (author), van Holten, J.C.A.M. (author), Balk, F. (author), Heijne den Bak-Glashouwer, M.J. (author), Leer, R. (author), Laman, J.D. (author), Boersma, W.J.A. (author), Claassen, E. (author), TNO Preventie en Gezondheid (author)In mice, strain dependent cytokine production profiles are induced after oral administration of Lactobacillus. Such a cytokine profile seems to determine the direction and efficacy of the humoral response. In SJL mice lactobacilli are able to enhance or inhibit the development of disease after induction of experimental autoimmune...article 1998
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), Woutersen, R.A. (author)Acrylonitrile is a monomer used extensively as a raw material in the manufacturing of acrylic fibers, plastics, synthetic rubbers, and acrylamide. It has been classified as a probable human carcinogen according to the results of numerous chronic rat bioassays. The present report summarizes the toxicity data on acrylonitrile and reviews available...article 1998
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voedin (author), Groten, J.P. (author), Tajima, O. (author), Feron, V.J. (author), Schoen, E.D. (author)For the accurate analysis of possible interactive effects of chemicals in a defined mixture, statistical designs are necessary to develop clear and manageable experiments. For instance, factorial designs have been successfully used to detect two-factor interactions. Particularly useful for this purpose are fractionated factorial designs,...article 1998
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), van Puymbroeck, M. (author), Kuilman, M.E.M. (author), Maas, R.F.M. (author), Witkamp, R.F. (author), Leyssens, L. (author), van der Zande, D.J.M. (author), Gelan, J. (author), Raus, J. (author)17alpha-Boldenone (17alpha-BOL) and/or 17beta-boldenone (17beta-BOL) appear occasionally in fecal matter of cattle. In addition to 17alpha-BOL, a whole array of boldenone related substances can be found in the same samples. In vitro experiments with microsomal liver preparations and isolated hepatocytes combined with the excretion profiles found...article 1998
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), de Brabander, H.F. (author), de Wasch, K. (author), van Ginkel, L.A. (author), Sterk, S.S. (author), Blokland, M.H. (author), Delahaut, Ph. (author), Taillieu, X. (author), Dubois, M. (author), Arts, C.J.M. (author), van Baak, M.J. (author), Gramberg, L.G. (author), Schilt, R. (author), van Bennekom, E.O. (author), Courtheyn, D. (author), Vercammen, J. (author), Witkamp, R.F. (author)The European Union banned the use of anabolic steroids for cattle fattening in 1988. Analytical techniques able to detect trace amounts of the parent drugs and their metabolites are mandatory for the control of abuse. Stanozolol (Stan) is an anabolic steroid that is often found in injection sites and cocktails. However, it has never been...article 1998
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), van Puymbroeck, M. (author), Kuilman, M.E.M. (author), Maas, R.F.M. (author), Witkamp, R.F. (author), Leyssens, T. (author), van der Zande, D.J.M. (author), Gelan, J. (author), Raus, J. (author)Current veterinary residue analysis mainly focuses on the monitoring of residues of the administered parent compound. However, it is possible that larger amounts of metabolites are excreted and that they can have a prolonged excretion period. In order to unravel specific metabolic steps and to identify possible biological markers, two in vitro...article 1998
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Schaafsma, G. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)Chemicals/CAS: Calcium, 7440-70-2; Magnesium, 7439-95-4article 1997
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- van Loon, A.J.M. (author), Botterweck, A.A.M. (author), Goldbohm, R.A. (author), Brants, H.A.M. (author), van den Brandt, P.A. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author) article 1997
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Koopman, J. (author), Maas, A. (author), Rezaee, F. (author), Havekes, L. (author), Verheijen, J. (author), Gijbels, M. (author), Haverkate, F. (author), Gaubius Instituut TNO (author)Atherosclerosis is a multifactorial disease that is influenced by both genetic and environmental factors. Recent epidemiological studies have shown that the combination of elevated VLDL/LDL concentrations and elevated fibrinogen levels results in a strong increase of the risk for cardiovascular disease as compared to the individual risk factors....article 1997
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van Poppel, G. (author), van den Berg, H. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)The prospect that high intake of certain vitamins may confer protection against cancer has drawn substantial attention during the last decades. This paper gives a concise update of the role of a number of promising vitamins in prevention of cancer. Vitamin A and its analogues have an important role in cellular processes related to carcinogenesis...article 1997
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- van den Berg, H. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author) article 1997