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Veugen, P.J.M. (author)When processing signals in the encrypted domain, homomorphic encryption can be used to enable linear operations on encrypted data. Comparison of encrypted data however requires an additional protocol between the parties and will be relatively expensive. A well-known and frequently used comparison protocol is by Damgard, Geisler and Kroigaard. We...conference paper 2012
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Kotlarski, J.D. (author), Moet, D.J.D. (author), Blom, P.W.M. (author)Lowering of the optical band gap of conjugated polymers in bulk heterojunction solar cells not only leads to an increased absorption but also to an increase of the optimal active layer thickness due to interference effects at longer wavelengths. The increased carrier densities due to the enhanced absorption and thicker active layers make low...article 2011
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Meekes, J.A.C. (author), Zhang, X. (author), Abdul Fattah, R. (author)Geophysical monitoring of the dynamical behavior of subsurface reservoirs (oil, gas, CO2) remains an important issue in geophysical research. A new idea for reservoir monitoring based on electrical resistivity tomography was developed at TNO. The essential element of the so-called BSEMT (Borehole to Surface Electrical Monitoring Technique)...conference paper 2011
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de Graaf, A.A. (author), van Schalkwijk, D.B. (author)At present, several measurement technologies are available for generating highly detailed concentration-size profiles of lipoproteins, offering increased diagnostic potential. Computational models are useful in aiding the interpretation of these complex datasets and making the data more accessible for clinical diagnosis. They do so by...article 2011
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van Schalkwijk, D.B. (author), van Bochove, K. (author), van Ommen, B. (author), Freidig, A.P. (author), van Someren, E.P. (author), van der Greef, J. (author), de Graaf, A.A. (author), TNO Kwaliteit van Leven (author)This article provides methodological and technical considerations to researchers starting to develop computational model-based diagnostics using clinical chemistry data.These models are of increasing importance, since novel metabolomics and proteomics measuring technologies are able to produce large amounts of data that are difficult to...article 2010
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Schutte, M.E. (author), Alink, G.M. (author), Freidig, A.P. (author), Spenkelink, B. (author), Vaessen, J.C.H. (author), van de Sandt, J.J.M. (author), Groten, J.P. (author), Rietjens, I.M.C.M. (author), TNO Kwaliteit van Leven (author), KvL (author)This study investigates whether the previous observation that quercetin increases the transport of PhIP through Caco-2 monolayers in vitro could be confirmed in an in vivo rat model. Co-administration of 1.45 μmol PhIP/kg bw and 30 μmol quercetin/kg bw significantly increased the blood AUC(0-8 h) of PhIP in rats to 131 ± 14% of the AUC(0-8 h)...article 2008
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van Maanen, P.P. (author), Klos, T. (author), van Dongen, C.J. (author), TNO Defensie en Veiligheid (author)This paper involves a human-agent system in which there is an operator charged with a pattern recognition task, using an automated decision aid. The objective is to make this human-agent system operate as effectively as possible. Effectiveness is gained by an increase of appropriate reliance on the operator and the aid. We studied whether it is...conference paper 2007
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McCoy, R.W. (author), Chou, C.C. (author), van de Velde, R. (author), Twisk, D. (author), van Schie, C. (author), TNO Industrie en Techniek (author)A computational model of a mid-size sport utility vehicle was developed using MADYMO. The model includes a detailed description of the suspension system and tire characteristics that incorporated the Delft-Tyre magic formula description. The model was correlated by simulating a vehicle suspension kinematics and compliance test. The correlated...conference paper 2007
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Werf, M.J.v.d. (author), Overkamp, K.M. (author), Muilwijk, B. (author), Coulier, L. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)Achieving metabolome data with satisfactory coverage is a formidable challenge in metabolomics because metabolites are a chemically highly diverse group of compounds. Here we present a strategy for the development of an advanced analytical platform that allows the comprehensive analysis of microbial metabolomes. Our approach started with in...article 2007
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Verwei, M. (author), van Burgsteden, J.A. (author), Krul, C.A.M. (author), van de Sandt, J.J.M. (author), Freidig, A.P. (author), TNO Kwaliteit van Leven (author)The new EU legislations for chemicals (Registration, Evaluation and Authorization of Chemicals, REACH) and cosmetics (Seventh Amendment) stimulate the acceptance of in vitro and in silico approaches to test chemicals for their potential to cause reproductive effects. In the current study seven compounds with known in vivo developmental effects...article 2006
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Schutte, M.E. (author), Freidig, A.P. (author), van de Sandt, J.J.M. (author), Alink, G.M. (author), Rietjens, I.M.C.M. (author), Groten, J.P. (author), TNO Kwaliteit van Leven (author)The present study describes the effect of different flavonoids on the absorption of the pro-carcinogen PhIP through Caco-2 monolayers and the development of an in silico model describing this process taking into account passive diffusion and active transport of PhIP. Various flavonoids stimulated the apical to basolateral PhIP transport. Using...article 2006
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Verwei, M. (author), Freidig, A.P. (author), Havenaar, R. (author), Groten, J.P. (author), TNO Kwaliteit van Leven (author)The nutritional quality of new functional or fortified food products depends on the bioavailability of the nutrient(s) in the human body. Bioavailability is often determined in human intervention studies by measurements of plasma or serum profiles over a certain time period. These studies are time and cost consuming and often appear to lack an...article 2006
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Damveld, R.A. (author), Arentshorst, M. (author), Franken, A. (author), van Kuyk, P.A. (author), Klis, F.M. (author), van den Hondel, C.A.M.J.J. (author), Ram, A.F.J. (author), TNO Kwaliteit van Leven (author)In Aspergillus niger, the genes coding for glutamine:fructose-6-phosphate amidotransferase (gfaA) and α-1,3-glucan synthase (agsA) are induced in response to cell wall stress. In silico analysis of the promoter region of the two genes revealed the presence of putative DNA binding sites for transcription factors involved in stress responses,...article 2005
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- Coecke, S. (author), Blaauboer, B.J. (author), Elaut, G. (author), Freeman, S. (author), Freidig, A. (author), Gensmantel, N. (author), Hoet, P. (author), Kapoulas, V.M. (author), Ladstetter, B. (author), Langley, G. (author), Leahy, D. (author), Mannens, G. (author), Meneguz, A. (author), Monshouwer, M. (author), Nemery, B. (author), Pelkonen, O. (author), Pfaller, W. (author), Prieto, P. (author), Proctor, N. (author), Rogiers, V. (author), Rostami-Hodjegan, A. (author), Sabbioni, E. (author), Steiling, W. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author) article 2005
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den Hartog, E.A. (author), Lotens, W.A. (author), TNO Technische Menskunde (author)In the Netherlands most murder victims are found 2-24 h after the crime. During this period, body temperature decrease is the most reliable method to estimate the postmortem time (PMT). Recently, two murder cases were analysed in which currently available methods did not provide a sufficiently reliable estimate of the PMT. In both cases a study...article 2004
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van Lieshout, J.J. (author), Toska, K. (author), van Lieshout, E.J. (author), Eriksen, M. (author), Walløe, L. (author), Wesseling, K.H. (author), TNO Biomedical Instrumentation (author)The proper understanding of the cardiovascular mechanisms involved in complaints of short-lasting dizziness and the evaluation of unexplained recurrent syncope requires continuous monitoring of cardiac stroke volume (SV) in addition to blood pressure and heart rate. The primary aim of the present study was to evaluate a pulse wave analysis...article 2003
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Verwei, M. (author), Arkbåge, K. (author), Havenaar, R. (author), van den Berg, H. (author), Witthöft, C. (author), Schaafsma, G. (author), TNO Voeding (author)Dairy products are a potential matrix for folate fortification to enhance folate consumption in the Western world. Milk folate-binding proteins (FBP) are especially interesting because they seem to be involved in folate bioavailability. In this study, folate bioaccessibility was investigated using a dynamic computer-controlled gastrointestinal...article 2003
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Verver, M.M. (author), van Hoof, J.F.A.M. (author), TNO Wegtransportmiddelen (author)Higher demands by people on the performance of vehicles and the comfort-related physical complaints by professional drivers have led to an increasing demand for more comfortable cars. Car manufacturers use comfort as an item to distinguish themselves from their competitors. However, the development and introduction of a new, more-comfortable car...conference paper 2003
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TNO Voeding (author), Venema, K. (author), van Nuenen, M.H.M.C. (author), van den Heuvel, E.G. (author), Pool, W. (author), van der Vossen, J.M.B.M. (author)The objective of this study was to compare the in vivo effect of lactulose on faecal parameters with the effect in a dynamic, computer-controlled in vitro model of the proximal large intestine (TIM-2). Faecal samples from 10 human volunteers collected before (non-adapted) and after 1 week of treatment (10 g/day) with lactulose (lactulose-adapted...article 2003
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TNO Bouw (author), Holck, O. (author), Svendsen, S. (author), Brunold, S. (author), Frei, U. (author), Köhl, M. (author), Heck, M. (author), Oversloot, H.P. (author)Humidity inside the collectors is one factor that can be minimised to keep the most favourable microclimatic condition for the internal materials of the collector. This microclimate inside the collector is an important factor in determining the service lifetime of an absorber coating. During the design of the collector, the location and size of...article 2003