Searched for: subject%3A%22colon%255C%2Bcarcinogenesis%22
(1 - 9 of 9)
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de Vogel, S. (author), Bongaerts, B.W.C. (author), Wouters, K.A.D. (author), Kester, A.D.M. (author), Schouten, L.J. (author), de Goeij, A.F.P.M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), van Engeland, M. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)
Intake of dietary factors that serve as methyl group donors may influence promoter hypermethylation in colorectal carcinogenesis. We investigated whether dietary folate, vitamin B2 and vitamin B6, methionine and alcohol were associated with mutL homologue 1 (MLH1) hypermethylation and the related molecular phenotypes of MLH1 protein expression,...
article 2008
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Hamer, H.M. (author), Jonkers, D. (author), Venema, K. (author), Vanhoutvin, S. (author), Troost, F.J. (author), Brummer, R.J. (author)
Background: Butyrate, a short-chain fatty acid, is a main end-product of intestinal microbial fermentation of mainly dietary fibre. Butyrate is an important energy source for intestinal epithelial cells and plays a role in the maintenance of colonic homeostasis. Aim: To provide an overview on the present knowledge of the bioactivity of butyrate,...
article 2008
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Brink, M. (author), Weijenberg, M.P. (author), de Goeij, A.F.P.M. (author), Schouten, L.J. (author), Koedijk, F.D.H. (author), Roemen, G.M.J.M. (author), Lentjes, M.H.F.M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding (author)
Associations between dietary intake of various fats and specific K-ras mutations in colorectal cancer (CRC) were investigated within the framework of The Netherlands Cohort Study on diet and cancer (NLCS). After 7.3 years of follow-up and with exclusion of the first 2.3 years, 448 colon and 160 rectal cancer patients and 2948 subcohort members ...
article 2004
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van Erk, M.J. (author), Teuling, E. (author), Staal, Y.C.M. (author), Huybers, S. (author), van Bladeren, P.J. (author), Aarts, J.M.M.J.G. (author), van Ommen, B. (author), TNO Voeding (author)
Background. Curcumin is a spice and a coloring food compound with a promising role in colon cancer prevention. Curcumin protects against development of colon tumors in rats treated with a colon carcinogen, in colon cancer cells curcumin can inhibit cell proliferation and induce apoptosis, it is an anti-oxidant and it can act as an anti...
article 2004
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Brink, M. (author), de Goeij, A.F.P.M. (author), Weijenberg, M.P. (author), Roemen, G.M.J.M. (author), Lentjes, M.H.F.M. (author), Pachen, M.M.M. (author), Smits, K.M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author)
Activation of K-ras oncogene has been implicated in colorectal carcinogenesis, being mutated in 30-60% of the adenocarcinomas. In this study, 737 incident colorectal cancer (CRC) patients, originating from 120 852 men and women (55-69 years at baseline) participating in the Netherlands Cohort Study (NLCS), were studied in order to evaluate...
article 2003
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Stierum, R. (author), Gaspari, M. (author), Dommels, Y. (author), Ouatas, T. (author), Pluk, H. (author), Jespersen, S. (author), Vogels, J. (author), Verhoeckx, K. (author), Groten, J. (author), van Ommen, B. (author)
Here, we describe a proteomics approach to study protein expression changes in differentiating Caco-2 cells. Caco-2 is a colorectal carcinoma cell line, which upon differentiation loses its tumorigenic phenotype and displays characteristics of mature enterocytes, including brush borders with microvilli. Cells were grown in culture flasks and...
article 2003
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Dommels, Y.E.M. (author), Heemskerk, S. (author), van den Berg, H. (author), Alink, G.M. (author), van Bladeren, P.J. (author), van Ommen, B. (author)
Modulating effects of high fat fish oil (HFFO) and high fat corn oil (HFCO) diets on azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) were studied in male F344 rats following 8 weeks of dietary treatment. The incidence of AOM-induced ACF was significantly lower in the proximal colon of rats fed the HFFO diets compared with rats fed...
article 2003
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van Engeland, M. (author), Weijenberg, M.P. (author), Roemen, G.M.J.M. (author), Brink, M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Baylin, S.B. (author), de Goeij, A.F.P.M. (author), Herman, J.G. (author)
Sporadic colorectal cancer (CRC) is characterized by genetic and epigenetic changes such as regional DNA hypermethylation and global DNA hypomethylation. Epidemiological and animal studies suggest that aherrant DNA methylation is associated with low dietary folate intake, which is aggravated by high alcohol intake. The relationship between...
article 2003
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Hambly, R.J. (author), Saunders, M. (author), Rijken, P.J. (author), Rowland, I.R. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Although there is much epidemiological evidence for an interaction between diet and colorectal cancer risk, the mechanisms by which diet might protect against colorectal cancer are still unclear. Here we report the significant up-regulation of carcinogen-induced apoptosis in the colon of rats fed a diet containing low-risk factors for colon...
article 2002
Searched for: subject%3A%22colon%255C%2Bcarcinogenesis%22
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