A case-cohort study on prostate cancer risk in relation to family history of prostate cancer

We investigated the risk of prostate cancer in relation to a family history of prostate cancer in 58,279 men ages 55-69 years. We found 704 incident cases after 6.3 years of follow-up. Rate ratios and 95% confidence intervals for having an affected vs nonaffected father and brother were, respectively 1.44 (0.80-2.58) and 5.57 (1.61-19.26). We...

Association of energy and fat intake with prostate carcinoma risk: Results from the Netherlands Cohort Study

BACKGROUND. The roles of energy and fat intake as risk factors for prostate carcinoma are still questionable. Therefore, these factors were evaluated in the Netherlands Cohort Study described in this article.

Dietary assessment in the elderly: Application of a two-step semiquantitative food frequency questionnaire for epidemiological studies

Objective: Description and application of an adapted semiquantitative food frequency questionnaire (SFFQ) for dietary assessment in the elderly population of the Rotterdam Study. Design: Dietary assessment consisting of a two-step approach was performed in 5434 participants (2225 men, 3029 women) of the Rotterdam Study from 1990 to 1993, a...

Diet in adolescence and the risk of breast cancer: Results of the Netherlands Cohort Study

Objectives: In The Netherlands, part of the population experienced food restriction and severe famine during World War II. The purpose of this study was to study the effects of severe undernutrition during adolescence on the risk of breast cancer later in life. Methods: We examined the hypothesis in the Netherlands Cohort Study on diet and...

Vegetable and fruit consumption and prostate cancer risk: A cohort study in the Netherlands

The association between 21 vegetables and eight fruits and prostate cancer risk was assessed in the Netherlands Cohort Study among 58,279 men of ages 55-69 years at baseline in 1986. After 6.3 years of follow-up, 610 cases with complete vegetable data and 642 cases with complete fruit data were available for analysis. In multivariate case-cohort...

The contribution of various foods to intake of vitamin A and carotenoids in the Netherlands

This study presents data on dietary intake of specific carotenoids in the Netherlands, based on a recently developed food composition database for carotenoids. Regularly eaten vegetables, the main dietary source of carotenoids, were sampled comprehensively and analysed with modern analytic methods. The database was complemented with data from...

Dietary assessment in the elderly: Validation of a semiquantitative food frequency questionnaire

Objective: The study was conducted to assess the relative validity of a 170-item semiquantitative food frequency questionnaire (SFFQ) adapted for use in the elderly. Design and subjects: The study was carried out in a sample of 80 men and women aged 55-75 y participating in a community based prospective cohort study in Rotterdam, The Netherlands...

Intake of nitrate and nitrite and the risk of gastric cancer: A prospective cohort study

The association between the intake of nitrate or nitrite and gastric cancer risk was investigated in a prospective cohort study started in 1986 in the Netherlands, of 120,852 men and women aged 55-69 years. At baseline, data on dietary intake, smoking habits and other covariates were collected by means of a self-administered questionnaire. For...

Nitrate intake and gastric cancer risk: Results from the Netherlands cohort study

Activated protein C response and cardiovascular risk factors in the elderly - The Rotterdam Study

Background and objective. A low activated protein C (APC) response increases the risk of venous thrombosis, and possibly arterial disease. Apart from the factor V Leiden mutation, other factors may determine the level of APC response. In most studies on the association with arterial disease, cardiovascular risk factors were not appropriately...

The relation between neonatal thyroxine levels and neurodevelopmental outcome at age 5 and 9 years in a national cohort of very preterm and/or very low birth weight infants

Transient neonatal hypothyroxinemia is very common in preterm infants. The literature on the effect of this hypothyroxinemia is, however, controversial, and large or long-term follow-up studies are not available. In a nationwide prospective follow-up study on very preterm and (or) very low birth weight infants (n = 717), we studied the...

Genetic determination of telomere size in humans: A twin study of three age groups

Reduction of telomere length has been postulated to be a causal factor in cellular aging. Human telomeres terminate in tandemly arranged repeat arrays consisting of the (TTAGGG) motif. The length of these arrays in cells from human mitotic tissues is inversely related to the age of the donor, indicating telomere reduction with age. In addition...

Ethnicity and maternal education as risk indicators for dental caries, and the role of dental behavior.

The aim of this study was to assess differences in dental health between socioeconomic and ethnic groups in a cohort of 5-yr-old children born in 1982 and in a cohort of 11-yr-old children born in 1976. A further aim was to evaluate the putative role of dental behaviors as intervening factors between ethnicity and maternal education on the one...

Etniciteit en het Besluit TJZ [Ethnicity and the TJZ decision]

The aim of this study was to assess differences in oral health and dental behaviour in a cohort of five-year-old children born in 1982 and a cohort of eleven-year-old children born in 1976, in different ethnic and socio-economic groups, in the period from 1987 to 1990. To this end a secondary analysis was performed on data collected in a study...

Delaying childbearing: Effect of age on fecundity and outcome of pregnancy

Objectives - To study the age of the start of the fall (critical age) in fecundity; the probability of a pregnancy leading to a healthy baby taking into account the age of the woman; and, combining these results, to determine the age dependent probability of getting a healthy baby. Design - Cohort study of all women who had entered a donor...