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ZhuParris, A. (author), de Goede, A.A. (author), Yocarini, I.E. (author), Kraaij, W. (author), Groeneveld, G.J. (author), Doll, R.J. (author)Background: Central nervous system (CNS) disorders benefit from ongoing monitoring to assess disease progression and treatment efficacy. Mobile health (mHealth) technologies offer a means for the remote and continuous symptom monitoring of patients. Machine Learning (ML) techniques can process and engineer mHealth data into a precise and...article 2023
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Michielsen, C.C.J.R. (author), Hangelbroek, R.W.J. (author), Bragt, M.C.E. (author), Verheij, E.R. (author), Wopereis, S. (author), Mensink, R.P. (author), Afman, L.A. (author)Scope: The drug fenofibrate and dietary fish oils can effectively lower circulating triglyceride (TG) concentrations. However, a detailed comparative analysis of the effects on the plasma metabolome is missing. Methods and Results: Twenty overweight and obese subjects participate in a double-blind, cross-over intervention trial and receive in a...article 2022
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Coert, R.M.H. (author), Timmis, J.K. (author), Boorsma, A (author), Pasman, W.J. (author)Background: Conventional clinical trials are essential for generating high-quality evidence by measuring the efficacy of interventions in rigorously controlled clinical environments. However, their execution can be expensive and time-consuming. In addition, clinical trials face several logistical challenges regarding the identification,...article 2021
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- Versluis, A. (author), Knulst, A.C. (author), Michelsen-Huisman, A.D. (author), Houben, G.F. (author), Blom, W.M. (author), Le, T.M. (author), van Os-Medendorp, H. (author) article 2021
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Patel, N. (author), Adelman, D.C. (author), Anagnostou, K. (author), Baumert, J.L. (author), Blom, W.M. (author), Campbell, D.E. (author), Chinthrajah, R.S. (author), Mills, E.N.C. (author), Javed, B. (author), Purington, N. (author), Remington, B.C. (author), Sampson, H.A. (author), Smith, A.D. (author), Yarham, R.A.R. (author), Turner, P.J. (author)Background Eliciting doses (EDs) (eg, ED01 or ED05 values, which are the amounts of allergen expected to cause objective symptoms in 1% and 5% of the population with an allergy, respectively) are increasingly being used to inform allergen labeling and clinical management. These values are generated from food challenge, but the frequency of...article 2021
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Austin, P.C. (author), White, I.R. (author), Lee, D.S. (author), van Buuren, S. (author)Missing data is a common occurrence in clinical research. Missing data occurs when the value of the variables of interest are not measured or recorded for all subjects in the sample. Common approaches to addressing the presence of missing data include complete-case analyses, in which subjects with missing data are excluded, or mean-value...article 2021
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Versluis, A. (author), van Os-Medendorp, H. (author), Blom, W.M. (author), Michelsen-Huisman, A.D. (author), Castenmiller, J.J.M. (author), Noteborn, H.P.J.M. (author), Houben, G.F. (author), Knulst, A.C. (author)Background: Cofactors, such as physical exercise and alcohol intake, might be associated with the severity or occurrence of food allergic reactions. Objective: To gain insight into the frequency of presence of potential cofactors in accidental food allergic reactions in adults and to what extent these factors influence the severity and...article 2019
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Havermans, B.M. (author), Boot, C.R.L. (author), Brouwers, E.P.M. (author), Houtman, I.L.D. (author), Anema, J.R. (author), van der Beek, A.J. (author)Objective: The objective was to evaluate the process and feasibility of a digital platform-based implementation strategy aimed at work stress prevention. Methods: The process evaluation was performed alongside a controlled trial within a health care organization, in the experimental group (N = 221). Mental models, context, and barriers and...article 2018
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Vermaire, J.H. (author)Objectives The aim of this study was to establish the effect of a non-operative caries treatment programme (the Nexø method) in a general dental practice on dental caries, oral hygiene and self-reported motivational factors for a 6-year period. Methods A randomized clinical controlled trial study on caries-preventive measures in 6- to 12-year...article 2018
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Fiamoncini, J. (author), Yiorkas, A.M. (author), Gedrich, K. (author), Rundle, M. (author), Alsters, S.I. (author), Roeselers, G. (author), van den Broek, T.J. (author), Clavel, T. (author), Lagkouvardos, I. (author), Wopereis, S. (author), Frost, G. (author), van Ommen, B. (author), Blakemore, A.I. (author), Daniel, H. (author)Bile acids (BA) are signaling molecules with a wide range of biological effects, also identified among the most responsive plasma metabolites in the postprandial state. We here describe this response to different dietary challenges and report on key determinants linked to its interindividual variability. Healthy men and women (n = 72, 62 ± 8 yr,...article 2017
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Boesveld, I.C. (author), Bruijnzeels, M.A. (author), Hitzert, M. (author), Hermus, M.A.A. (author), van der Pal-de Bruin, K.M. (author), van den Akker-van Marle, M.E. (author), Steegers, E.A.P. (author), Franx, A. (author), de Vries, R.G. (author), Wiegers, T.A. (author)Background: The goal of integrated care is to offer a continuum of care that crosses the boundaries of public health, primary, secondary, and tertiary care. Integrated care is increasingly promoted for people with complex needs and has also recently been promoted in maternity care systems to improve the quality of care. Especially when located...article 2017
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van den Broek, T.J. (author), Bakker, G.C.M. (author), Rubingh, C.M. (author), Bijlsma, S. (author), Stroeve, J.H.M. (author), van Ommen, B. (author), van Erk, M.J. (author), Wopereis, S. (author)Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. A systemic review defined an optimal nutritional challenge test, the "PhenFlex test" (PFT). Recently, it has been shown that the PFT enables the quantification of all relevant metabolic processes involved in maintaining or regaining homeostasis of...article 2017
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Grimshaw, K. (author), Logan, K. (author), O'Donovan, S. (author), Kiely, M. (author), Patient, K. (author), van Bilsen, J. (author), Beyer, K. (author), Campbell, D.E. (author), Garcia-Larsen, V. (author), Grabenhenrich, L. (author), Lack, G. (author), Mills, C. (author), Wal, J.M. (author), Roberts, G. (author)Recommendations and guidelines on the prevention of food allergy have changed in recent decades. The aim of this review of the current evidence and ongoing studies is to provide a comprehensive and up to date picture of prevention of food allergy for healthcare professionals. The review was undertaken as part of the European Union funded...article 2017
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de Lijster, G.P.A. (author), Felten, H. (author), Kok, G. (author), Kocken, P.L. (author)Many adolescents experience sexual harassment and victims of sexual harassment have higher risks regarding well-being and health behaviors such as higher risks of suicidal thoughts, suicidal ideation and feeling unsafe at school. A peer-performed play and school lessons on preventing sexual harassment behavior were presented to secondary school...article 2016
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Kocken, P.L. (author), Scholten, A.M. (author), Westhoff, E. (author), Kok, B.P.H. (author), Taal, E.M. (author), Goldbohm, R.A. (author)The effectiveness of the “Extra Fit!” (EF!) education program in promoting healthy diet and physical activity to prevent and reduce overweightness among primary school children aged 9 to 11 was evaluated. A randomized controlled design was carried out in 45 primary schools (n = 1112) in the Netherlands, 23 intervention and 22 control schools....article 2016
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Wierenga, D. (author), Engbers, L.H. (author), van Empelen, P. (author), van Mechelen, W. (author)Objective: The aim of this study was to evaluate the use of and adherence to a 7-step strategy for the development, implementation, and continuation of a comprehensive, multicomponent lifestyle program. Methods: Strategy use and adherence was assessed with 12 performance indicators. Data were collected by combining onsite monitoring with semi...article 2016
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Broekman, H. (author), Verhoeckx, K.C. (author), den Hartog Jager, C.F. (author), Kruizinga, A.G. (author), Pronk-Kleinjan, M. (author), Remington, B.C. (author), Bruijnzeel-Koomen, C.A. (author), Houben, G.F. (author), Knulst, A.C. (author)The growing world population motivates the exploration of new sustainable protein sources to ensure food security. Insects such as mealworm (Tenebrio molitor) are promising candidates, with active ongoing marketing efforts within America and Europe. This warrants assessment of the potential risks. Toxicologic and microbiological risks were...article 2016
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Schrieks, I.C. (author), Heil, A.L. (author), Hendriks, H.F. (author), Mukamal, K.J. (author), Beulens, J.W. (author)OBJECTIVE: Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes. This reduced risk might be explained by improved insulin sensitivity or improved glycemic status, but results of intervention studies on this relation are inconsistent. The purpose of this study was to conduct a systematic review and meta-analysis of...article 2015
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Vlaming, M.L. (author), van Duijn, E. (author), Dillingh, M.R. (author), Brands, R. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Bosgra, S. (author), Burggraaf, J. (author), de Koning, M.C. (author), Fidder, A. (author), Mocking, J.A. (author), Sandman, H. (author), de Ligt, R.A. (author), Fabriek, B.O. (author), Pasman, W.J. (author), Seinen, W. (author), Alves, T. (author), Carrondo, M. (author), Peixoto, C. (author), Peeters, P.A. (author), Vaes, W.H. (author)Preclinical development of new biological entities (NBEs), such as human protein therapeutics, requires considerable expenditure of time and costs. Poor prediction of pharmacokinetics in humans further reduces net efficiency. In this study, we show for the first time that pharmacokinetic data of NBEs in humans can be successfully obtained early...article 2015
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Turner, M.A. (author), Mooij, M.G. (author), Vaes, W.H.J. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Knibbe, C.A.J. (author), Körgvee, L.T. (author), Maruszak, W. (author), Grynkiewicz, G. (author), Garner, R.C. (author), Tibbocl, D. (author), Park, B.K. (author), de Wildt, S.N. (author)Important information gaps remain on the efficacy and safety of drugs in children. Pediatric drug development encounters several ethical, practical, and scientifîc chaflenges One barrier to the evaluation of medicines for children is a lack of Innovative methodologies that have been adapted to the needs of chiIdren This article presents our...article 2015