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Moné, M.J. (author), Pallocca, G. (author), Escher, S.E. (author), Exner, T. (author), Herzler, M. (author), Hougaard Bennekou, S. (author), Kamp, H. (author), Kroese, E.D. (author), Leist, M. (author), Steger-Hartmann, T. (author), van de Water, B. (author)
In 2016, the European Commission launched the EU-ToxRisk research project to develop and promote animal-free approaches in toxicology. The 36 partners of this consortium used in vitro and in silico methods in the context of case studies (CSs). These CSs included both compounds with a highly defined target (e.g. mitochondrial respiratory chain...
article 2020
Ball, N. (author), Cronin, M.T.D. (author), Shen, J. (author), Blackburn, K. (author), Booth, E.D. (author), Bouhifd, M. (author), Donley, E. (author), Egnash, L. (author), Hastings, C. (author), Juberg, D.R. (author), Kleensang, A. (author), Kleinstreuer, N. (author), Kroese, E.D. (author), Lee, A.C. (author), Luechtefeld, T. (author), Maertens, A. (author), Marty, S. (author), Naciff, J.M. (author), Palmer, J. (author), Pamies, D. (author), Penman, M. (author), Richarz, A.N. (author), Russo, D.P. (author), Stuard, S.B. (author), Patlewicz, G. (author), van Ravenzwaay, B. (author), Wu, S. (author), Zhu, H. (author), Hartung, T. (author)
Grouping of substances and utilizing read-across of data within those groups represents an important data gap filling technique for chemical safety assessments. Categories/analogue groups are typically developed based on structural similarity and, increasingly often, also on mechanistic (biological) similarity. While read-across can play a key...
article 2016
Höfer, T. (author), James, D. (author), Syversen, T. (author), Bowmer, T. (author)
Data on acute lethal inhalation toxicity from animal studies are commonly required for assessing the hazards to human health of volatile, gaseous and dusty chemicals or their mixtures. The International Maritime Organisation (IMO) made the provision of acute inhalation toxicity data a mandatory requirement for the carriage of bulk liquid...
article 2011