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Shahmohammadi, M.S. (author), Parker, L.A. (author), Henke, S. (author), Urbanus, J.H. (author)Microplastics are a growing environmental and toxicological concern, having been found in the remotest locations of the earth and within multiple organs of the human body. However, the scale of the problem is not yet fully known as the smallest micro- and nanoplastics (MNPs) cannot accurately be measured due to limitations in measurement and...article 2022
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Hemme, M. (author), Fidder, A. (author), van der Riet-van Oeveren, D. (author), van der Schans, M.J. (author), Noort, D. (author)The primary aim of this study was to identify biomarkers of exposure to some so-called Schedule 1 sulfur mustard (HD) analogues, in order to facilitate and expedite their retrospective analysis in case of alleged use of such compounds. Since these HD analogues can be regarded as model compounds for possible impurities of HD formed during...article 2021
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Steijn, W.M.P. (author), van Kampen, J.N. (author), van der Beek, D. (author), Groeneweg, J. (author), van Gelder, P.H.A.J.M. (author)Quantitative Risk Analysis (QRA) is a standard tool in some high-risk industries (such as the on- and offshore exploration and production and chemical industry). Presently, existing knowledge concerning human error likelihood and human reliability assessment is insufficiently represented in QRAs. In this paper we attempt to implement the...article 2020
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Bezemer, K. (author), McLennan, L. (author), van Duin, L. (author), Kuijpers, C.J. (author), Koeberg, M. (author), van den Elshout, J.J.M.H. (author), van der Heijden, A.E.D.M. (author), Busby, T. (author), Yevdokimov, A. (author), Schoenmakers, P. (author), Smith, J. (author), Oxley, J. (author), van Asten, A. (author)Erythritol tetranitrate (ETN) was prepared independently by two research groups from the USA and the Netherlands. The partially nitrated impurities present in ETN were studied using liquid chromatography-mass spectrometry to address the ultimate challenge in forensic explosives investigations, i.e., providing chemical and tactical information on...article 2020
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- de Weert, J. (author), Smedes, F. (author), Beeltje, H. (author), de Zwart, D. (author), Hamers, T. (author) article 2020
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Bouma, R.H.B. (author), Griffiths, T.T. (author), Tuukkanen, I.M. (author)To ensure safety and reliability, it is important that the explosives and other materials used in munitions do not interact adversely either physically or chemically. Data obtained by heat flow calorimetry on nitrocellulose-based propellants have been reviewed with the aim of identifying improved chemical compatibility assessment criteria. It...article 2019
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TerHeege, J.H. (author), Wollenweber, J. (author), Naumann, M. (author), Pipilikaki, P. (author), Vercauteren, F. (author)Wells used for steam-assisted gravity drainage (SAGD), for cyclic steam stimulation (CSS), for hydrocarbon production in areas with anomalous high geothermal gradient, or for geothermal energy extraction all are operated in high temperature environments where maintaining long term wellbore integrity is one of the key challenges. Changes in...conference paper 2019
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Keulen, A. (author), van Zomeren, A. (author), Dijkstra, J.J. (author)This study explores the leaching of oxyanionic metalloid species (As, Mo, Se, V and Cr) from alkali activated slag-fly ash materials (AAM), dependent on various mixture parameters i.e., activator molarity, slag-fly ash precursor/binder compositions, liquid to binder ratio, curing time and strength. The analyses focusses on the leaching of...article 2018
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van den Berg, T.W. (author), Cramp, A. (author)Deployment and execution of HLA federates in Docker containers offers many benefits. However, managing the execution of multiple HLA federate containers to run a complete HLA federation across a set of compute nodes in a local area network or in a cloud environment can be time consuming and error prone. A small HLA federation can easily consist...conference paper 2018
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Raaphorst, R.M. (author), Savolainen, H. (author), Cantore, M. (author), van de Steeg, E. (author), van Waarde, A. (author), Colabufo, N.A. (author), Elsinga, P.H. (author), Lammertsma, A.A. (author), Windhorst, A.D. (author), Luurtsema, G. (author)Positron emission tomography (PET) imaging of P-glycoprotein (P-gp) in the blood-brain barrier can be important in neurological diseases where P-gp is affected, such as Alzheimer’s disease. Radiotracers used in the imaging studies are present at very small, nanomolar, concentration, whereas in vitro assays where these tracers are characterized,...article 2017
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Fransman, W. (author), Bekker, C. (author), Tromp, P. (author), Duis, W.B. (author)Increasing production and applications of manufactured nano objects (MNOs) have become a source for human exposure and therefore raise concerns and questions about the possible health effects. In this study, the potential release of nano objects, their agglomerates, and aggregates (NOAA) as a result of sanding of hardwood treated with MNOs...article 2016
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Timkovsky, J. (author), Dusek, U. (author), Henzing, J.S. (author), Kuipers, T.L. (author), Röckmann, T. (author), Holzinger, R. (author)We present a novel approach to study the organic composition of aerosol filter samples using thermal-desorption proton-transfer-reaction mass spectrometry (TD-PTR-MS) in the laboratory. The method is tested and validated based on the comparison with in situ TD-PTR-MS measurements. In general, we observe correspondence within the levels of...article 2015
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Koster, S. (author), Leeman, W.R. (author), Verheij, E.R. (author), Dutman, A.E. (author), van Stee, L.L.P. (author), Munch Nielsen, L. (author), Ronsmans, S. (author), Noteborn, H. (author), Krul, L. (author)A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult...article 2015
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Lever, T. (author), Haines, P. (author), Rouquerol, J. (author), Charsley, E.L. (author), van Ekeren, P.J. (author), Burlett, D.J. (author), Macan, J. (author)The widespread use of thermal analysis (TA) by scientists as a laboratory technique carries with it a working vocabulary. This document is intended to provide those working in the field with a consistent set of definitions to permit clear and precise communication as well as understanding. Included in the document are the definitions of 13...article 2015
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Kroese, E.D. (author), Bosgra, S. (author), Buist, H.E. (author), Lewin, G. (author), van der Linden, S.C. (author), Man, H.Y. (author), Piersma, A.H. (author), Rorije, E. (author), Schulpen, S.H.W. (author), Schwarz, M. (author), Uibel, F. (author), van Vugt-Lussenburg, B.M.A. (author), Wolterbeek, A.P.M. (author), van der Burg, B. (author)Previously we showed a battery consisting of CALUX transcriptional activation assays, the ReProGlo assay, and the embryonic stem cell test, and zebrafish embryotoxicity assay as 'apical' tests to correctly predict developmental toxicity for 11 out of 12 compounds, and to explain the one false negative [7]. Here we report on applying this battery...article 2015
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Walser, T. (author), Meyer, D. (author), Fransman, W. (author), Buist, H. (author), Kuijpers, E. (author), Brouwer, D. (author)Life-Cycle Assessment (LCA) is a well-established method to evaluate impacts of chemicals on the environment and human health along the lifespan of products. However, the increasingly produced and applied nanomaterials (defined as one dimensionarticle 2015
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Verweij, J.M. (author), Kunakbayeva, G. (author), Klomp, A.L. (author), Ghazaryan, L. (author), Koolmees, H.H. (author), Pluymaekers, M.P.D. (author), Hegen, D. (author)Main objective of the project presented in this paper is to improve the quantitative knowledge and understanding of the distribution of pore fluid pressures and fluid dynamic conditions in the subsurface of onshore and offshore Netherlands. Such knowledge and understanding is of great importance for optimizing -responsible -exploration and use...conference paper 2014
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Ambrus, R. (author), Radacsi, N. (author), Szunyogh, T. (author), van der Heijden, A.E.D.M. (author), ter Horst, J.H. (author), Szabó-Révész, P. (author)Interest in submicron-sized drug particles has emerged from both laboratory and industrial perspectives in the last decade. Production of crystals in the nano size scale offers a novel way to particles for drug formulation solving formulation problems of drugs with low solubility in class II of the Biopharmaceutical Classification System. In...article 2013
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Mutlu, E. (author), Warren, S.H. (author), Matthews, P.P. (author), King, C. (author), Linak, W.P. (author), Kooter, I.M. (author), Schmid, J.E. (author), Ross, J.A. (author), Ian Gilmour, M. (author), DeMarini, D.M. (author)Several types of diesel exhaust particles (DEPs) have been used for toxicology studies, including a highorganic automobile DEP (A-DEP) from Japan, and a low-organic forklift DEP developed by the National Institute of Standards and Technology (N-DEP). However, these DEPs were not characterized extensively for chemical composition or sub...article 2013
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van Gaans, P.F.M. (author), Griffioen, J. (author), Mol, G. (author), Klaver, G. (author)Purpose: Sedimentary aquifers are prone to anthropogenic disturbance. Measures aimed at mitigation or adaptation require sound information on the reactivity of soil/sediments towards the infiltrating water, as this determines the chemical quality of the groundwater and receiving surface waters. Here, we address the issues of relevant sediment...article 2011