Searched for: subject%3A%22central%255C%2Bnervous%255C%2Bsystem%22
(41 - 60 of 62)
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Instituut voor Zintuigfysiologie TNO (author), Heynen, H. (author), van Norren, D. (author)Responses to 400 msec flashes of white light were recorded at various depth in the retina of the intact macaque eye. A statistical technique, principal component analysis (PCA), was used to isolate independent components from the LERG, using the changing contribution of a cell's response to the LERG with retinal depth. Two approaches were...article 1985
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de Jonge, G. (author), Dienske, H. (author), Sanders-Woundstra, J.A.R. (author), Primatencentrum TNO (author)A comparison was made between the behaviour of 61 severely socially deprived children and 41 controls during a psychiatric screening session. Ages ranged from 1.5 to 12 years. The occurrence of directly observable ethological categories of social interaction, activity and play was determined by use of a keyboard. Problem children differed from...article 1984
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- Tans, J.T.J. (author), Poortvliet, D.C.J. (author), Instituut voor Gezondheidstechniek TNO Medisch Biologisch Laboratorium TNO (author) article 1984
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Prins Maurits Laboratorium TNO (author), Ligtenstein, D.A. (author), Kossen, S.P. (author)The kinetic profile of the oxime HI-6, a potent cholinesterase reactivator, after iv administration of 0.1325 mmol/kg (50 mg/kg) to rats is described. The blood concentrations measured over a period of 300 min can be described by a two-compartment open model. Excretion occurred only by the kidney. Approximately 60% was excreted in unmetabolized...article 1983
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Hooisma, J. (author), Medisch Biologisch Laboratorium TNO (author)Application of tissue culture in neurotoxicology may serve two purposes. First, they may be used to unravel the mechanism of action of neurotoxic compounds and secondly, they may be used for the screening of neurotoxic agents. Studies belonging to the first group can be subdivided into those aiming at the replication of neurotoxic processes in...article 1982
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Tulleken, C.A.F. (author), van Dieren, A. (author), ten Veen, J. (author), Lopes Da Silva, F.H. (author), TNO Workgroup Clin. Neurophysiol., Westeinde Hosp., The Hague, Netherlands Medisch Biologisch Laboratorium TNO (author)The local EEG, the local cerebral blood flow (lCBF), and the flow in the distal stump of the occluded middle cerebral artery were simultaneously recorded in 28 acute experiments in cats. Nembutal anesthesia was used eleven times, and Halothane anaesthesia 17 times. The recordings were made via platinum electrodes: 12 in the ischaemic hemisphere,...article 1982
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Centraal Instituut voor Voedingsonderzoek TNO (author), Appelman, L.M. (author), Woutersen, R.A. (author), Feron, V.J. (author)The 4-h LC50 of acetaldehyde in rats was determined and found to be 13,300 ppm (24.0 g/m3 air). In a 4-week study groups of 10 male and 10 female rats were exposed to 0, 400, 1000, 2200 or 5000 ppm acetaldehyde for 6 h/day, 5 days/week. Treatment-related changes observed at the 5000 ppm level included dyspnoea and excitation during the first 30...article 1982
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Hooisma, J. (author), Dam, E.W. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: 2 hexanone, 591-78-6; acetonylacetone, 110-13-4; hexane, 110-54-3article 1981
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Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)The effects of etiracetam, a structural analogue or piracetam, were investigated in rats on Y-maze discrimination acquisition, on open field behavior, on one-trial passive avoidance learning and on shuttlebox acquisition and extinction. The results indicate that this drug significantly enhances acquisition and may improve retention without...article 1981
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van der Kogel, A.J. (author), Radiobiologisch Instituut (author)Chemicals/CAS: cytarabine, 147-94-4, 69-74-9; methotrexate, 15475-56-6, 59-05-2, 7413-34-5article 1981
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Ponsen, L. (author), Jonkman, E.J. (author), TNO Res. Unit Clin. Neurophysiol., c/o Westeinde Hosp., 2512 VA The Hague, Netherlands Medisch Biologisch Laboratorium TNO (author)Part I of this article reviewed aetiological and clinical phenomena related to the Creutzfeldt-Jakob disease. A case history of one patient was presented together with some electro-encephalographic aspects in relation to this disease and results of computer analysis of the EEG. The slow virus concept and its implications for treatment of...article 1981
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de Koning-Verest, I.F. (author), Medisch Biologisch Laboratorium TNO (author)The metabolism of glutamate, taken as an index of the metabolic state of the brain, was studied in brains of 3-, 12- and 30-month-old rats. Following the injection of a mixture of [3H]acetate and d-[2-14C]glucose, the brain levels of glutamate and aspartate were decreased in 30-month-old rats when compared with those of 3-month-old rats. No...article 1980
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Medisch Biologisch Laboratorium TNO (author), Hooisma, J. (author), Groot, D.M.G.de (author), Magchielse, T. (author), Muijser, H. (author)Chick spinal ganglia, chick muscle cells combined with mouse spinal cord explants, C1300 neuroblastoma cells, Chinese hamster ovary cells and newborn rat cerebral cells were exposed to various concentrations of acrylamide in culture. Four morphological and 1 electrophysiological parameter were applied in order to score toxic effects. It appeared...article 1980
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- Gaubius instituut TNO (author), Mosmans, P.C.M. (author), Jonkman, E.J. (author) article 1980
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Feron, V.J. (author), Kroes, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Wistar rats were exposed to atmospheres containing 0 (control) or 5000 ppm vinyl chloride monomer (VCM), 7 h/day, 5 days/week, for a period of 52 weeks. After 4, 13, 26 and 52 weeks each time 10 rats/sex/group were killed and subjected to extensive examinations. The present paper describes the morphological changes observed in the respiratory...article 1979
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Gaillard, A.W.K. (author), Varey, C.A. (author), Instituut voor Zintuigfysiologie TNO (author)The effects (on human beings) of the ACTH analog Org 2766 were investigated for a range of performance tests: complicated serial reaction task, running memory span, verbal learning and non-verbal mental ability tests (closure flexibility and non-verbal abstraction). Subjective ratings on feeling were taken and heart rate was measured. Only the...article 1979
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Perdok, J. (author), Gaillard, A.W.K. (author), Instituut voor Zintuigfysiologie TNO (author)Slow EEG potentials were recorded during the foreperiod of a signal detection task which involved different levels of discrimination difficulty. The subject was requried to react to S2 as quickly as possible or to delay his responses by 1 s. It was found that the contingent negative variation (CNV) was attenuated when no speeded response was...article 1979
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Feron, V.J. (author), Kruysse, A. (author), Immel, H.R. (author), Til, H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The subacute inhalation toxicity of butenolide was examined in hamsters by repeated exposure of 4 groups of 10 males and 10 females to butenolide vapour at concentrations of 0, 5.4, 25 and 130 ppm respectively (6 h/day, 5 days/week) for a period of 13 weeks. The effects found at 130 ppm included eye irritation, salivation, nasal discharge,...article 1979
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Tulleken, C.A.F. (author), van Dieren, A. (author), Mollevanger, W.J. (author), van Eijck, P. (author), Inst. Med. Phys., TNO, Utrecht, Netherlands (author)In a group of 21 cats, the middle cerebral artery pressure (MCAP) was recorded by means of a catheter introduced into the artery at its origin, just distal to the occlusion. The effects of hypertension, hypercapnia, and hypocapnia were studied. In a group of five cats, both middle cerebral arteries (MCA) were catheterized and the pressure was...article 1978
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Tanger, H.J. (author), Vanwersch, R.A.P. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)A method is described whereby open field behaviour of rats can be automatically registered using a TV camera, a video converter, an X-Y recorder and a papertape puncher. Use is made of the scanning properties of the TV camera to obtain the X and Y coordinates of the rat's position and to print this position on an X-Y recorder to obtain the...article 1978
Searched for: subject%3A%22central%255C%2Bnervous%255C%2Bsystem%22
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