Searched for: subject%3A%22cancer%255C%2Bprevention%22
(1 - 19 of 19)
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Dihal, A.A. (author), van der Woude, H. (author), Hendriksen, P.J.M. (author), Charif, H. (author), Dekker, L.J. (author), IJsselstijn, L. (author), de Boer, V.C.J. (author), Alink, G.M. (author), Burgers, P.C. (author), Rietjens, I.M.C.M. (author), Woutersen, R.A. (author), Stierum, R.H. (author), TNO Kwaliteit van Leven (author), KvL (author)
Quercetin has been shown to act as an anticarcinogen in experimental colorectal cancer (CRC). The aim of the present study was to characterize transcriptome and proteome changes occurring in the distal colon mucosa of rats supplemented with 10 g quercetin/kg diet for 11 wk. Transcriptome data analyzed with Gene Set Enrichment Analysis showed...
article 2008
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Finglas, P.M. (author), de Meer, K. (author), Molloy, A. (author), Verhoef, P. (author), Pietrzik, K. (author), Powers, H.J. (author), van der Straeten, D. (author), Jägerstad, M. (author), Varela-Moreiras, G. (author), van Vliet, T. (author), Havenaar, R. (author), Buttriss, J. (author), Wright, A.J.A. (author), TNO Kwaliteit van Leven (author)
In the past decade, the understanding of folate bioavailability, metabolism and related health issues has increased, but several problems remain, including the difficulty of delivering the available knowledge to the populations at risk. Owing to the low compliance of taking folic acid supplements, for example, among women of child-bearing age...
article 2006
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Männistö, S. (author), Dixon, L.B. (author), Balder, H.F. (author), Virtanen, M.J. (author), Krogh, V. (author), Khani, B.R. (author), Berrino, F. (author), van den Brandt, P.A. (author), Hartman, A.M. (author), Pietinen, P. (author), Tan, F. (author), Wolk, A. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven TNO Voeding (author)
Objective: Only a few consistent findings on individual foods or nutrients that influence breast cancer risk have emerged thus far. Since people do not consume individual foods but certain combinations of them, the analysis of dietary patterns may offer an additional aspect for assessing associations between diet and diseases such as breast...
article 2005
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van Erk, M.J. (author), Krul, C.A.M. (author), Caldenhoven, E. (author), Stierum, R.H. (author), Peters, W.H. (author), Woutersen, R.A. (author), van Ommen, B. (author), TNO Kwaliteit van Leven TNO Voeding (author)
Interest in mechanisms of colon cancer prevention by food compounds is strong and research in this area is often performed with cultured colon cancer cells. In order to assess utility for screening of potential cancer-preventive (food) compounds, expression profiles of 14 human cell lines derived from colonic tissue were measured using cDNA...
article 2005
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Männistö, S. (author), Smith-Warner, S.A. (author), Spiegelman, D. (author), Albanes, D. (author), Anderson, K. (author), van den Brandt, P.A. (author), Cerhan, J.R. (author), Colditz, G. (author), Feskanich, D. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Miller, A.B. (author), Rohan, T.E. (author), Virtamo, J. (author), Willett, W.C. (author), Hunter, D.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Intervention trials with supplemental β-carotene have observed either no effect or a harmful effect on lung cancer risk. Because food composition databases for specific carotenoids have only become available recently, epidemiological evidence relating usual dietary levels of these carotenoids with lung cancer risk is limited. We analyzed the...
article 2004
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Dixon, L.B. (author), Balder, H.F. (author), Virtanen, M.J. (author), Rashidkhani, B. (author), Männistö, S. (author), Krogh, V. (author), van den Brandt, P.A. (author), Hartman, A.M. (author), Pietinen, P. (author), Tan, F. (author), Virtamo, J. (author), Wolk, A. (author), Goldbohm, R.A. (author), TNO Voeding (author)
Background: An analysis of dietary patterns or combinations of foods may provide insight regarding the influence of diet on the risk of colon and rectal cancer. Objective: A primary aim of the Dietary Patterns and Cancer (DIETSCAN) Project was to develop and apply a common methodologic approach to study dietary patterns and cancer in 4 European...
article 2004
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Smith-Warner, S.A. (author), Spiegelman, D. (author), Yaun, S.-S. (author), Albanes, D. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Feskanich, D. (author), Folsom, A.R. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Kushi, L.H. (author), Miller, A.B. (author), Pietinen, P. (author), Rohan, T.E. (author), Speizer, F.E. (author), Willett, W.C. (author), Hunter, D.J. (author)
Inverse associations between fruit and vegetable consumption and lung cancer risk have been consistently reported. However, identifying the specific fruits and vegetables associated with lung cancer is difficult because the food groups and foods evaluated have varied across studies. We analyzed fruit and vegetable groups using standardized...
article 2003
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Balder, H.F. (author), Virtanen, M. (author), Brants, H.A.M. (author), Krogh, V. (author), Dixon, L.B. (author), Tan, F. (author), Mannisto, S. (author), Bellocco, R. (author), Pietinen, P. (author), Wolk, A. (author), Berrino, F. (author), van den Brandt, P.A. (author), Hartman, A.M. (author), Goldbohm, R.A. (author)
The association between diet and cancer, predominantly investigated univariately, has often been inconsistent, possibly because of the large number of candidate risk factors and their high intercorrelations. Analysis of dietary patterns is expected to give more insight than analysis of single nutrients or foods. This study aimed to develop and...
article 2003
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Dommels, Y.E.M. (author), Heemskerk, S. (author), van den Berg, H. (author), Alink, G.M. (author), van Bladeren, P.J. (author), van Ommen, B. (author)
Modulating effects of high fat fish oil (HFFO) and high fat corn oil (HFCO) diets on azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) were studied in male F344 rats following 8 weeks of dietary treatment. The incidence of AOM-induced ACF was significantly lower in the proximal colon of rats fed the HFFO diets compared with rats fed...
article 2003
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Zeegers, M.P.A. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author)
In the Netherlands Cohort Study among 120 852 subjects aged 55-69 years at baseline (1986), the association between vitamins and carotenoids intake, vitamin supplement use, and bladder cancer incidence was examined. Exposure status was measured with a food-frequency questionnaire. After 6.3 years of follow-up, data from 569 cases and 3123...
article 2001
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van Poppel, G. (author), Verhoeven, D.T.H. (author), Verhagen, H. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
This paper first gives an overview of the epidemiological data concerning the cancer-preventive effect of brassica vegetables, including cabbages, kale, broccoli, Brussels sprouts, and cauliflower. A protective effect of brassicas against cancer may be plausible due to their relatively high content of glucosinolates. Certain hydrolysis products...
article 2000
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Woutersen, R.A. (author), Wolterbeek, A.P.M. (author), Appel, M.J. (author), van den Berg, H. (author), Goldbohm, R.A. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The safety of β-carotene was reassessed by evaluating the relevant literature on the beneficial and adverse effects of β-carotene on cancer and, in particular, by evaluating the results of toxicity studies. β- Carotene appeared neither genotoxic nor reprotoxic or teratogenic, and no signs of organ toxicity have been found in subacute, subchronic...
article 1999
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Woutersen, R.A. (author), Appel, M.J. (author), Garderen van -Hoetmer, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Previously performed short-term (4-month) studies demonstrated that vitamins C and E, β-carotene and selenium modulate growth of early putative preneoplastic acinar lesions induced in rat pancreas by azaserine. The present paper summarizes the results of long-term studies performed with azaserine-treated rats maintained on diets high in either β...
article 1999
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Botterweck, A.A.M. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The association between vegetable and fruit consumption and stomach cancer risk was investigated in the Netherlands Cohort Study among 120,852 men and women aged 55-69 years at the start in September 1986. Analyses were based on 282 incident stomach cancer cases after 6.3 years of follow-up. Age- and sex-adjusted rate ratios of stomach cancer in...
article 1998
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Sherratt, P.J. (author), Manson, M.M. (author), Thomson, A.M. (author), Hissink, E.A.M. (author), Neal, G.E. (author), van Bladeren, P.J. (author), Green, T. (author), Hayes, J.D. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A characteristic feature of the class Theta glutathione S-transferase (GST) T1-1 is its ability to activate dichloromethane and dibromoethane by catalysing the formation of mutagenic conjugates. The level of the GSTT1 subunit within tissues is an important determinant of susceptibility to the carcinogenic effects of these dihaloalkanes. In the...
article 1998
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van Poppel, G. (author), van den Berg, H. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
The prospect that high intake of certain vitamins may confer protection against cancer has drawn substantial attention during the last decades. This paper gives a concise update of the role of a number of promising vitamins in prevention of cancer. Vitamin A and its analogues have an important role in cellular processes related to carcinogenesis...
article 1997
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Verhoeven, D.T.H. (author), Verhagen, H. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), van Poppel, G. (author)
The mechanisms by which brassica vegetables might decrease the risk of cancer are reviewed in this paper. Brassicas, including all types of cabbages, broccoli, cauliflower and Brussels sprouts, may be protective against cancer due to their relatively high glucosinolate content. Glucosinolates are usually broken down through hydrolysis catalyzed...
article 1997
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Verhoeven, D.T.H. (author), Goldbohm, R.A. (author), van Poppel, G. (author), Verhagen, H. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
This paper gives an overview of the epidemiological data concerning the cancer-preventive effect of brassica vegetables, including cabbage, kale, broccoli, Brussels sprouts, and cauliflower. The protective effect of brassicas against cancer may be due to their relatively high content of glucosinolates. Certain hydrolysis products of...
article 1996
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van Poppel, G. (author), Poulsen, H. (author), Loft, S. (author), Verhagen, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1995
Searched for: subject%3A%22cancer%255C%2Bprevention%22
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