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Boot, H. (author)In the past decades, the standard approach in the modelling of consequences of pool and jet fires would be to describe these fires as tilted cylindrical shaped radiating flame surfaces, having a specific SEP (Surface Emissive Power). Some fine tuning on pool fires has been done by Rew and Hulbert in the late nineties to divide the flame in a...conference paper 2016
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Joustra, S.D. (author), van der Plas, E.M. (author), Goede, J. (author), Oostdijk, W. (author), Delemarre-van de Waal, H.A. (author), Hack, W.W.M. (author), van Buuren, S. (author), Wit, J.M. (author)Aim Accurate calculations of testicular volume standard deviation (SD) scores are not currently available. We constructed LMS-smoothed age-reference charts for testicular volume in healthy boys. Methods The LMS method was used to calculate reference data, based on testicular volumes from ultrasonography and Prader orchidometer of 769 healthy...article 2015
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Vlaming, M.L. (author), van Duijn, E. (author), Dillingh, M.R. (author), Brands, R. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Bosgra, S. (author), Burggraaf, J. (author), de Koning, M.C. (author), Fidder, A. (author), Mocking, J.A. (author), Sandman, H. (author), de Ligt, R.A. (author), Fabriek, B.O. (author), Pasman, W.J. (author), Seinen, W. (author), Alves, T. (author), Carrondo, M. (author), Peixoto, C. (author), Peeters, P.A. (author), Vaes, W.H. (author)Preclinical development of new biological entities (NBEs), such as human protein therapeutics, requires considerable expenditure of time and costs. Poor prediction of pharmacokinetics in humans further reduces net efficiency. In this study, we show for the first time that pharmacokinetic data of NBEs in humans can be successfully obtained early...article 2015
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Turner, M.A. (author), Mooij, M.G. (author), Vaes, W.H.J. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Knibbe, C.A.J. (author), Körgvee, L.T. (author), Maruszak, W. (author), Grynkiewicz, G. (author), Garner, R.C. (author), Tibbocl, D. (author), Park, B.K. (author), de Wildt, S.N. (author)Important information gaps remain on the efficacy and safety of drugs in children. Pediatric drug development encounters several ethical, practical, and scientifîc chaflenges One barrier to the evaluation of medicines for children is a lack of Innovative methodologies that have been adapted to the needs of chiIdren This article presents our...article 2015
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Polinder, H. (author), Spiekman, M.E. (author), van Dijk, H.A.L. (author)A next generation of models is needed to guarantee energy performances of buildings and systems in practice. Current energy performance models use assumptions on climate, user behavior, characteristics of building and systems that may deviate from reality. Improvement of the accuracy of these models and assumptions is necessary to better predict...article 2015
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Jolani, S. (author), Debray, T.P.A. (author), Koffijberg, H. (author), van Buuren, S. (author), Moons, K.G.M. (author)Individual participant data meta-analyses (IPD-MA) are increasingly used for developing and validating multivariable (diagnostic or prognostic) risk prediction models. Unfortunately, some predictors or even outcomes may not have been measured in each study and are thus systematically missing in some individual studies of the IPD-MA. As a...article 2015
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Davydenko, I. (author), Ehrler, V. (author), de Ree, D. (author), Lewis, A. (author), Tavasszy, L. (author)Improving the efficiency and sustainability of supply chains is a shared aim of the transport industry, its customers, governments as well as industry organisations. To optimize supply chains and for the identification of best practice, standards for their analysis are needed in order to achieve comparable evaluations. This need for an...article 2014
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Makri, E. (author), Everts, M.H. (author), de Hoogh, S. (author), Peter, A. (author), op den Akker, H. (author), Hartel, P.H. (author), Jonker, W. (author)We treat the problem of privacy-preserving statistics verification in clinical research. We show that given aggregated results from statistical calculations, we can verify their correctness efficiently, without revealing any of the private inputs used for the calculation. Our construction is based on the primitive of Secure Multi-Party...conference paper 2014
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- Walters, C.L. (author), Voormeeren, L.O. (author) conference paper 2014
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Damoni, C. (author), Belletti, B. (author), Lilliu, G. (author)In this paper the behavior of a squat shear wall subjected to monotonic shear loading is investigated. The study fits into the experimental program driven by CEOS.fr on modeling of the behavior of the tested mocks-ups (monotonic and cycling loading-under prevented or free shrinkage). The shear wall has been analyzed with nonlinear finite element...conference paper 2013
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- van Dommelen, P. (author), Schönbeck, Y. (author), van Buuren, S. (author) article 2012
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Mulckhuyse, W.F.W. (author), Lahaye, D. (author), Belitskaya, A. (author)In 3D reconstruction problems the number of design variables is large and the forward model is typically computationally expensive. Reconstruction using gradient-based optimization algorithms requires many gradient computations. For such problems the computational cost of a finite difference approach to gradient calculation is prohibitive since...conference paper 2012
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Maljaars, J. (author), Steenbergen, R.D.J.M. (author)The operating mechanisms of movable bridges are subjected to various types of fluctuating loads which may induce fatigue damage. Wind load acting on the bridge deck - when the bridge is open - is one of the important load types. A wind load model is proposed that can be used in the fatigue design verification. The model is based on wind...article 2012
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Kotlarski, J.D. (author), Blom, P.W.M. (author)We present the model calculations to explore the potential of polymer:fullerene tandem solar cells. As an approach we use a combined optical and electrical device model, where the absorption profiles are used as starting point for the numerical current-voltage calculations. With this model a maximum power efficiency of 11.7% for single cells has...article 2011
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Polder, R.B. (author), Peelen, W.H.A. (author), Neeft, E.A.C. (author), Stoop, B.T.J. (author), TNO Bouw en Ondergrond (author)Over the last 25 years, cathodic protection (CP) of reinforced concrete structures suffering from chloride induced reinforcement corrosion has shown to be successful and durable. CP current causes steel polarisation, electrochemical reactions and ion transport in the concrete. CP systems are designed based on experience, which results in...article 2010
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Koster, T. (author), Peelen, W. (author), Larbi, J. (author), de Rooij, M. (author), Polder, R. (author), TNO Bouw en Ondergrond (author)A mathematical model is being developed to describe a repair method in concrete, called cathodic protection (CP). The model is in principle also useful to describe electrodeposition in concrete, e.g. the process of re-precipitation of Ca(OH)<sub>2</sub> invoked by an electrical current. In CP, the current is sent from an external anode to the...article 2010
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Oudshoorn, A. (author), van den Berg, C. (author), Roelands, C.P.M. (author), Straathof, A.J.J. (author), van der Wielen, L.A.M. (author), TNO Industrie en Techniek (author)Microorganisms are generally sensitive to high concentrations of products that they excrete. Such product inhibition and toxicity effects can significantly be reduced by the integration of fermentations with separation technologies to remove the products continuously. Cost-calculations are required to select the preferred integration method....article 2010
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Wunderli, J.M. (author), Salomons, E.M. (author), TNO Bouw en Ondergrond (author)A model is presented to predict the reflection of sound at forest edges. A single tree is modelled as a vertical cylinder. For the reflection at a cylinder an analytical solution is given based on the theory of scattering of spherical waves. The entire forest is represented by a line of cylinders placed along the forest edge. The spacing between...article 2009
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Kudryavtsev, Y.V. (author), Gelinck, E.R.M. (author), Fischer, H.R. (author), TNO Industrie en Techniek (author)A theoretical investigation of van der Waals forces acting between two solid silicon surfaces at separations from zero to approximately 20 nm is presented. We focused our efforts on the analysis of different factors that can cause deviations from the classical pressure-distance dependence p ∼ 1/D3. It is demonstrated that a layer (oxide or water...article 2009
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Salomons, E.M. (author), van Maercke, D. (author), Randrianoelina, A. (author), TNO Bouw en Ondergrond (author)The Harmonoise sound propagation model ('the Harmonoise engineering model') was developed in the European project Harmonoise (2001-2004) for road and rail traffic noise. In 2008, CSTB Grenoble and TNO Delft have prepared a detailed description of the various steps involved in a calculation with the Harmonoise model. In the course of this joint...conference paper 2009