Searched for: subject%3A%22butyric%255C%2Bacid%22
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Shidachi, R. (author), Matsuhisa, N. (author), Zalar, P. (author), Chow, P.C.Y. (author), Jinno, H. (author), Yokota, T. (author), Someya, T. (author)
In this paper, the amplification of the photocurrent in organic phototransistors (OPTs) employing bulk heterojunctions (BHJs) with different donor–acceptor ratios has been studied. As a model system, poly[2-methoxy-5-(3’,7’-dimethyloctyloxy)-p-phenylene vinylene] (OC1C10-PPV) and [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) are used as...
article 2018
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Kotlarski, J.D. (author), Moet, D.J.D. (author), Blom, P.W.M. (author)
Lowering of the optical band gap of conjugated polymers in bulk heterojunction solar cells not only leads to an increased absorption but also to an increase of the optimal active layer thickness due to interference effects at longer wavelengths. The increased carrier densities due to the enhanced absorption and thicker active layers make low...
article 2011
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Moet, D.J.D. (author), de Bruyn, P. (author), Kotlarski, J.D. (author), Blom, P.W.M. (author)
Polymer solar cells based on the polyfluorene copolymer poly[9,9-didecanefluorene-alt-(bis-thienylene) benzothiadiazole] (PF10TBT) and the fullerene derivative [6,6]-phenyl C61-butyric acid methyl ester (PCBM) exhibit a power conversion efficiency of 4%. However, the optimum thickness of the photoactive layer is only 80 nm, such that these solar...
article 2010
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Hamer, H.M. (author), Jonkers, D.M.A.E. (author), Renes, I.B. (author), Vanhoutvin, S.A.L.W. (author), Kodde, A. (author), Troost, F.J. (author), Venema, K. (author), Brummer, R.-J.M. (author), TNO Kwaliteit van Leven (author)
INTRODUCTION: The colonic mucus layer plays an important role in the protection of the intestinal epithelium and mainly consists of mucin glycoproteins (primarily MUC2 in the colon) trefoil factor 3 (TFF3) and secretory IgA. Butyrate is a major end product of fermentation of dietary fibres and is associated with beneficial effects on colonic...
article 2010
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Jarzab, D. (author), Cordella, F. (author), Lenes, M. (author), Kooistra, F.B. (author), Blom, P.W.M. (author), Hummelen, J.C. (author), Loi, M.A. (author), TNO Industrie en Techniek (author)
Blends of poly(3-hexylthiophene) (P3HT) and the bis-adduct of [6,61-pheuyl-C\61-butyric acid methyl ester (bisPCBM) show enhanced performances in bulk-heterojunction solar cells compared to P3HT:PCBM thin films due to their higher open-circuit voltage. However, it is not clear whether the decrease of the shortcircuit current observed in P3HT...
article 2009
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Kovatcheva-Datchary, P. (author), Egert, M. (author), Maathuis, A. (author), Rajilić-Stojanović, M. (author), de Graaf, A.A. (author), Smidt, H. (author), de Vos, W.M. (author), Venema, K. (author), TNO Kwaliteit van Leven (author)
Summary Carbohydrates, including starches, are an important energy source for humans, and are known for their interactions with the microbiota in the digestive tract. Largely, those interactions are thought to promote human health. Using 16S ribosomal RNA (rRNA)-based stable isotope probing (SIP), we identified starch-fermenting bacteria under...
article 2009
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Hamer, H.M. (author), Jonkers, D. (author), Venema, K. (author), Vanhoutvin, S. (author), Troost, F.J. (author), Brummer, R.J. (author)
Background: Butyrate, a short-chain fatty acid, is a main end-product of intestinal microbial fermentation of mainly dietary fibre. Butyrate is an important energy source for intestinal epithelial cells and plays a role in the maintenance of colonic homeostasis. Aim: To provide an overview on the present knowledge of the bioactivity of butyrate,...
article 2008
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de Graaf, A.A. (author), Venema, K. (author), TNO Kwaliteit van Leven (author)
The importance of the human large intestine for nutrition, health, and disease, is becoming increasingly realized. There are numerous indications of a distinct role for the gut in such important issues as immune disorders and obesity-linked diseases. Research on this long-neglected organ, which is colonized by a myriad of bacteria, is a rapidly...
conference paper 2008
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Meesters, R.J.W. (author), van Eijk, H.M.H. (author), ten Have, G.A.M. (author), de Graaf, A.A. (author), Venema, K. (author), van Rossum, B.E.J. (author), Deutz, N.E.P. (author), TNO Kwaliteit van Leven (author)
A new method involving zinc sulphate deproteinization was developed to study short chain fatty acids (SCFA) production in the colon and subsequent occurrence of SCFA in blood. SCFA were baseline separated in a 30 min cycle using ion-exclusion chromatography and detected by mass spectrometry. Concentrations could be measured down to 10 μM and...
article 2007
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Egert, M. (author), de Graaf, A.A. (author), Maathuis, A. (author), de Waard, P. (author), Plugge, C.M. (author), Smidt, H. (author), Deutz, N.E.P. (author), Dijkema, C. (author), de Vos, W.M. (author), Venema, K. (author), TNO Kwaliteit van Leven (author)
16S rRNA-based stable isotope probing (SIP) and nuclear magnetic resonance (NMR) spectroscopy-based metabolic profiling were used to identify bacteria fermenting glucose under conditions simulating the human intestine. The TIM-2 in vitro model of the human intestine was inoculated with a GI tract microbiota resembling that of the small intestine...
article 2007
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Fässler, C. (author), Arrigoni, E. (author), Venema, K. (author), Brouns, F. (author), Amadò, R. (author), TNO Kwaliteit van Leven (author)
The in vitro fermentability of two resistant starch preparations type 2 (RS2) and type 3 (RS3) was investigated using human colonic microbiota. Prior to the fermentation experiments, samples were digested using two in vitro models, a batch (ba) and a dynamic (dy), as well as an in vivo method (il) for RS3. Digestion residues were fermented in...
article 2006
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Venema, K. (author), Vermunt, S.H.F. (author), Brink, E.J. (author), TNO Kwaliteit van Leven (author)
D-Tagatose is partly absorbed in the stomach and small intestine. Most of it is fermented by the large intestinal microbiota. The effect of D-tagatose on the composition of the microbiota and production of short chain fatty acids (SCFAs) was studied in vivo and in vitro. Gastrointestinal (GI) complaints were also studied. The in vivo study was...
article 2005
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van Nuenen, M.H.M.C. (author), de Ligt, R.A.F. (author), Doornbos, R.P. (author), van der Woude, J.C.J. (author), Kuipers, E.J. (author), Venema, K. (author), TNO Kwaliteit van Leven (author)
Microbial metabolites may influence the metabolic integrity of intestinal epithelial cells and induce mucosal immune responses. Therefore, we investigated the effects of the microbial metabolites butyrate, iso-valerate, and ammonium on Caco-2 cells and macrophages. Barrier functioning was determined by measuring transepithelial electrical...
article 2005
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Kooistra, T. (author), Lansink, M. (author), Emeis, J.J. (author), TNO Preventie en Gezondheid (author)
Chemicals/CAS: 4 [2 (5,6,7,8 tetrahydro 5,5,8,8 tetramethyl 2 naphthyl) 1 propenyl]benzoic acid, 71441-28-6; butyric acid, 107-92-6, 156-54-7, 461-55-2; cyclic AMP, 60-92-4; protein kinase C, 141436-78-4; retinoic acid, 302-79-4; tissue plasminogen activator, 105913-11-9; trichostatin A, 58880-19-6
article 1996
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Arts, J. (author), Lansink, T. (author), Grimbergen, J. (author), Toet, K.H. (author), Kooistra, T. (author), Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
We have previously shown that the pleiotropic agent sodium butyrate strongly stimulates tissue-type plasminogen activator (t-PA) expression in human umbilical vein endothelial cells (HUVEC). Here we provide the following evidence that the butyrate-induced t-PA expression in HUVEC involves histone H4 acetylation. (1) t-PA induction by butyrate...
article 1995
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Schrauwen, Y. (author), de Vries, R.E.M. (author), Kooistra, T. (author), Emeis, J.J. (author), TNO Preventie en Gezondheid (author)
The acute release of t-PA was studied in vitro in human endothelial cells from different origin. It proved possible to enhance the amounts of t-PA which can be released by increasing t-PA synthesis, both in vitro, and in vivo in rats. These data suggest the feasibility to induce and (or) enhance acute release of t-PA in man. Chemicals/CAS:...
article 1994
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Kaptein, A. (author), Roodenburg, L. (author), Princen, H.M.G. (author), Gaubius Institute TNO Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
Addition of sodium butyrate to the culture medium of the human hepatoma cell line Hep G2 resulted in a time- and dose-dependent increase in the secretion of apolipoprotein A-I (apo A-I) and apolipoprotein B100 (apo B100). After a 24 h preincubation period, a 2.4- and 2.2-fold increase in the secretion of apo A-I and apo B100 respectively was...
article 1991
document
van den Berg, K.J. (author), van Raaij, J.A.G.M. (author), Bragt, P.C. (author), Notten, W.R.F. (author), Medisch Biologisch Laboratorium TNO (author)
Previous results in experimental systems have suggested that hydroxylated PCBs may decrease thyroid hormone levels through associative interaction with transthyretin. In the present paper it was investigated whether this property was also shared by various industrial chemicals, mainly pesticides. In total, 65 compounds from 12 chemical groups...
article 1991
document
Kooistra, T. (author), Opdenberg, J.P. (author), Toet, K. (author), Hendriks, H.F.J. (author), van den Hoogen, R.M. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
Tissue-type plasminogen activator (t-PA) and its inhibitor, plasminogen activator inhibitor 1 (PAI-1), play an important role in regulating the fibrinolytic capacity of plasma. Both t-PA and PAI-1 are synthesized by the endothelium. We report that retinoic acid (vitamin A acid) and other retinoids rather specifically stimulate the production of...
article 1991
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Gaubius instituut TNO (author), Kooistra, T. (author), van den Berg, J. (author), Tons, A. (author), Platenburg, G. (author), Rijken, D.C. (author), van den Berg, E.A. (author)
Incubation of cultured human endothelial cells with 5-mM-dibutyryl cyclic AMP led to an approx. 2-fold increase in tissue-type plasminogen-activator (t-PA) production over a 24 h incubation period. The stimulating effect of dibutyryl cyclic AMP could be explained by the slow liberation of butyrate, as the effect could be reproduced by addition...
article 1987
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