Searched for: subject:"breast%5C+cancer"
(1 - 20 of 31)

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Amirabadi, H. Eslami (author), Tuerlings, M. (author), Hollestelle, A. (author), SahebAli, S. (author), Luttge, R. (author), van Donkelaar, C.C. (author), Martens, J.W.M. (author), den Toonder, J.M.J. (author)
E-cadherin is a cell-cell adhesion protein that plays a prominent role in cancer invasion. Inactivation of E-cadherin in breast cancer can arise from gene promoter hypermethylation or genetic mutation. Depending on their E-cadherin status, breast cancer cells adopt different morphologies with distinct invasion modes. The tumor microenvironment ...
article 2019
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van Groen, B.D. (author), van de Steeg, E. (author), Mooij, M.G. (author), van Lipzig, M.M.H. (author), de Koning, B.A.E. (author), Verdijk, R.M. (author), Wortelboer, H.M. (author), Gaedigk, R. (author), Bi, C. (author), Leeder, S. (author), van Schaik, R.H.N. (author), van Rosmalen, J. (author), Tibboel, D. (author), Vaes, W.H. (author), de Wildt, S.N. (author)
Background Hepatic membrane transporters are involved in the transport of many endogenous and exogenous compounds, including drugs. We aimed to study the relation of age with absolute transporter protein expression in a cohort of 62 mainly fetus and newborn samples. Methods Protein expressions of BCRP, BSEP, GLUT1, MCT1, MDR1, MRP1, MRP2, MRP3,...
article 2018
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Heikkila, K. (author), Nyberg, S.T. (author), Madsen, I.E. (author), de Vroome, E. (author), Alfredsson, L. (author), Bjorner, J.B. (author), Borritz, M. (author), Burr, H. (author), Erbel, R. (author), Ferrie, J.E. (author), Fransson, E. (author), Geuskens, G.A. (author), Hooftman, W.E. (author), Houtman, I.L. (author), Jöckel, K.H. (author), Knutsson, A. (author), Koskenvuo, M. (author), Lunau, T. (author), Nielsen, M.L. (author), Nordin, M. (author), Oksanen, T. (author), Pejtersen, J.H. (author), Pentti, J. (author), Shipley, M.J. (author), Steptoe, A. (author), Suominen, S.B. (author), Theorell, T. (author), Vahtera, J. (author), Westerholm, P.J.M. (author), Westerlund, H. (author), Dragano, N. (author), Rugulies, R. (author), Kawachi, I. (author), Batty, G.D. (author), Singh-Manoux, A. (author), Virtanen, M. (author), Kivimäki, M. (author)
Background: Working longer than the maximum recommended hours is associated with an increased risk of cardiovascular disease, but the relationship of excess working hours with incident cancer is unclear. Methods: This multi-cohort study examined the association between working hours and cancer risk in 116 462 men and women who were free of...
article 2016
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Velikova, M. (author), Dutra, I. (author), Burnside, E.S. (author)
The development and use of computerized decision-support systems in the domain of breast cancer has the potential to facilitate the early detection of disease
bookPart 2015
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Koppes, L.J.J. (author), Geuskens, G.A. (author), Pronk, A. (author), Vermeulen, R.C.H. (author), de Vroome, E.M.M. (author)
Experimental studies in animals indicate that disruption of the circadian rhythm is carcinogenic, and night work has been suggested to be a probable breast cancer cause in humans. Findings among humans, however are inconsistent, often gathered with retrospective study designs, and only based on specific populations, such as nurses. We used data...
article 2014
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Koeman, T. (author), van den Brandt, P.A. (author), Slottje, P. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), Kromhout, H. (author), Vermeulen, R. (author)
Purpose: To investigate the association between exposure to occupational extremely low-frequency magnetic fields (ELF-MF) and the risk of a priori selected cancer outcomes within the prospective Netherlands Cohort Study. Methods: 120,852 men and women aged 55-69 years at time of enrollment in 1986 were followed up (17.3 years) for incident lung,...
article 2014
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Kim, E.S. (author), Cha, Y. (author), Ham, M. (author), Jung, J. (author), Kim, S.G. (author), Hwang, S. (author), Kleemann, R. (author), Moon, A. (author)
A crucial role of the inflammatory lipid sphingosine-1-phosphate (S1P) in breast cancer aggressiveness has been reported. Recent clinical studies have suggested that C-reactive protein (CRP) has a role in breast cancer development. However, limited information is available on the molecular basis for the expression of CRP and its functional...
article 2014
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Overberg, R. (author), de Man, A. (author), Wolterbeek, R. (author), Otten, W. (author), Zwetsloot-Schonk, B. (author)
This study examined writer characteristics and themes written about in a set of 167 spontaneously published stories on a Dutch website for young women with breast cancer. The stories were coded for 6 disease characteristics and 16 themes. Coding results were compared with the characteristics of young women with breast cancer in a hospital cancer...
article 2013
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Bausch-Goldbohm, R.A. (author), Collaborative Group on Hormonal Factors in Breast Cancer (author)
BACKGROUND:Menarche and menopause mark the onset and cessation, respectively, of ovarian activity associated with reproduction, and affect breast cancer risk. Our aim was to assess the strengths of their effects and determine whether they depend on characteristics of the tumours or the affected women.METHODS:Individual data from 117...
article 2012
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Pedersen, G.S. (author), Hogervorst, J.G.F. (author), Schouten, L.J. (author), Konings, E.J.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Acrylamide, a potential human carcinogen, has been discovered in a variety of heat-treated carbohydrate-rich food products. Previously, dietary acrylamide intake was shown to be associated with endocrine-related cancers in humans. We assessed the association between dietary acrylamide intake and risk of postmenopausal breast cancer stratified by...
article 2010
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Zeegers, M.P. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Familial clustering of cancer is expected to occur at practically all anatomical sites. However, few studies have had sufficient size to investigate different sites simultaneously and with adjustment for confounders. We evaluated familial clustering in the Netherlands Cohort Study in which 120,852 men and women, aged 55-69 years in 1986 were...
article 2008
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Hogervorst, J.G. (author), Schouten, L.J. (author), Konings, E.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Background: Acrylamide, a probable human carcinogen, was detected in various heat-treated carbohydrate-rich foods in 2002. The few epidemiologic studies done thus far have not shown a relationship with cancer. Our aim was to investigate the association between acrylamide intake and endometrial, ovarian, and breast cancer risk. Methods: The...
article 2007
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Schutte, M.E. (author), Freidig, A.P. (author), van de Sandt, J.J.M. (author), Alink, G.M. (author), Rietjens, I.M.C.M. (author), Groten, J.P. (author), TNO Kwaliteit van Leven (author)
The present study describes the effect of different flavonoids on the absorption of the pro-carcinogen PhIP through Caco-2 monolayers and the development of an in silico model describing this process taking into account passive diffusion and active transport of PhIP. Various flavonoids stimulated the apical to basolateral PhIP transport. Using...
article 2006
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Visser, O. (author), van Peppen, A.M. (author), Öry, F.G. (author), van Leeuwen, F.E. (author), TNO Preventie en Gezondheid (author)
To determine breast cancer screening results according to country of birth data were used from the breast cancer screening organization of the Comprehensive Cancer Centre Amsterdam, the Netherlands. Overall (age-adjusted) attendance of the breast cancer screening was 76% for women aged 50-69. Attendance was significantly lower for women born in...
article 2005
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Männistö, S. (author), Dixon, L.B. (author), Balder, H.F. (author), Virtanen, M.J. (author), Krogh, V. (author), Khani, B.R. (author), Berrino, F. (author), van den Brandt, P.A. (author), Hartman, A.M. (author), Pietinen, P. (author), Tan, F. (author), Wolk, A. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven TNO Voeding (author)
Objective: Only a few consistent findings on individual foods or nutrients that influence breast cancer risk have emerged thus far. Since people do not consume individual foods but certain combinations of them, the analysis of dietary patterns may offer an additional aspect for assessing associations between diet and diseases such as breast...
article 2005
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van Zanden, J.J. (author), Geraets, L. (author), Wortelboer, H.M. (author), van Bladeren, P.J. (author), Rietjens, I.M.C.M. (author), Cnubben, N.H.P. (author), TNO Voeding (author)
The objective of this study was to investigate the structural requirements necessary for inhibition of glutathione S-transferase P1-1 (GSTP1-1) and GS-X pump (MRP1 and MRP2) activity by structurally related flavonoids, in GSTP1-1 transfected MCF7 cells (pMTG5). The results reveal that GSTP1-1 activity in MCF7 pMTG5 cells can be inhibited by some...
article 2004
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Visser, O. (author), van der Kooy, K. (author), van Peppen, A.M. (author), Öry, F.G. (author), van Leeuwen, F.E. (author), TNO Preventie en Gezondheid (author)
We investigated breast cancer incidence in migrants in the Netherlands in 1988-1998. The standardised incidence ratio for breast cancer in Northwest-Netherlands was statistically significantly reduced for women born in Surinam (0.56), Turkey (0.29) and Morocco (0.22). The proportion of women with advanced stages (III and IV) did not differ...
article 2004
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Balder, H.F. (author), Virtanen, M. (author), Brants, H.A.M. (author), Krogh, V. (author), Dixon, L.B. (author), Tan, F. (author), Mannisto, S. (author), Bellocco, R. (author), Pietinen, P. (author), Wolk, A. (author), Berrino, F. (author), van den Brandt, P.A. (author), Hartman, A.M. (author), Goldbohm, R.A. (author)
The association between diet and cancer, predominantly investigated univariately, has often been inconsistent, possibly because of the large number of candidate risk factors and their high intercorrelations. Analysis of dietary patterns is expected to give more insight than analysis of single nutrients or foods. This study aimed to develop and...
article 2003
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Missmer, S.A. (author), Smith-Warner, S.A. (author), Spiegelman, D. (author), Yaun, S.-S. (author), Adami, H.-O. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Fraserf, G.E. (author), Freudenheim, J.L. (author), Goldbohm, R.A. (author), Graham, S. (author), Kushi, L.H. (author), Miller, A.B. (author), Potter, J.D. (author), Rohan, T.E. (author), Speizer, F.E. (author), Toniolo, P. (author), Willett, W.C. (author), Wolk, A. (author), Zeleniuch-Jacquotte, A. (author), Hunter, D.J. (author)
Background. More than 20 studies have investigated the relation between meat and dairy consumption and breast cancer risk with conflicting results. Our objective was evaluate the risk of breast cancer associated with meat and dairy food consumption and to assess whether non-dietary risk factors modify the relation. Methods. We combined the...
article 2002
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TNO Preventie en Gezondheid (author), David Banta, H. (author), Oortwijn, W. (author), Cranovsky, R. (author)
Objective: To present a summary of the papers in this volume, illustrating the links between health technology assessment (HTA), health policies and specifically policies toward prevention and screening, and implementation of screening tests in the case of three screening methods: mammography screening for breast cancer, screening for prostate...
article 2001
Searched for: subject:"breast%5C+cancer"
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