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van der Harst, M.R. (author), de Groot, J. (author), Kiers, G.H. (author), Brama, P.A.J. (author), van de Lest, C.H.A. (author), van Weeren, P.R. (author)Objective - To assess whether site-related changes in biochemical composition are present in the cartilage and subchondral and trabecular bone of the metacarpophalangeal joint of horses with early osteoarthritis. Sample population - Right metacarpophalangeal joints from 59 mature warmblood horses. Procedure - Biochemical data (cross-link, amino...article 2005
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Rookmaaker, M.B. (author), Verhaar, M.C. (author), Loomans, C.J.M. (author), Verloop, R. (author), Peters, E. (author), Westerweel, P.E. (author), Murohara, T. (author), Staal, F.J.T. (author), van Zonneveld, A.J. (author), Koolwijk, P. (author), Rabelink, T.J. (author), van Hinsbergh, V.W.M. (author), TNO Kwaliteit van Leven (author)Objective - Emerging evidence suggests that human blood contains bone marrow (BM)-derived endothelial progenitor cells that contribute to postnatal neovascularization. Clinical trials demonstrated that administration of BM-cells can enhance neovascularization. Most studies, however, used crude cell populations. Identifying the role of different...article 2005
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Lamers, R.J.A.N. (author), van Nesselrooij, J.H.J. (author), Kraus, V.B. (author), Jordan, J.M. (author), Renner, J.B. (author), Dragomir, A.D. (author), Luta, G. (author), van der Greef, J. (author), de Groot, J. (author), TNO Kwaliteit van Leven (author)Objective: Osteoarthritis (OA) is one of the most common diseases among the elderly. The main characteristic is the progressive destruction of articular cartilage. We lack quantitative and sensitive biomarkers for OA to detect changes in the joints in an early stage of the disease. In this study, we investigated whether a urinary metabolite...article 2005
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Lin, Y.L. (author), Brama, P.A.J. (author), Kiers, G.H. (author), de Groot, J. (author), van Weeren, P.R. (author), TNO Preventie en Gezondheid (author)Objective - To quantify and compare biochemical characteristics of the extracellular matrix (ECM) of specimens harvested from tensional and compressive regions of the superficial digital flexor tendon (SDFT) of horses in age classes that include neonates to mature horses. Sample population - Tendon specimens were collected on postmortem...article 2005
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Hernandez, C.J. (author), Tang, S.Y. (author), Baumbach, B.M. (author), Hwu, P.B. (author), Sakkee, A.N. (author), van der Ham, F. (author), de Groot, J. (author), Bank, R.A. (author), Keaveny, T.M. (author), TNO Preventie en Gezondheid (author)The propensity of individual trabeculae to fracture (microfracture) may be important clinically since it could be indicative of bone fragility. Whether or not an overloaded trabecula fractures is determined in part by its structural ductility, a mechanical property that describes how much deformation a trabecula can sustain. The overall goal of...article 2005
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Dhonukshe-Rutten, R.A.M. (author), van Dusseldorp, M. (author), Schneede, J. (author), de Groot, L.C.P.G.M. (author), van Staveren, W.A. (author), TNO Kwaliteit van Leven (author)Background: Cobalamin deficiency is prevalent in vegetarians and has been associated with increased risk of osteoporosis. Aim of the study: To examine the association between cobalamin status and bone mineral density in adolescents formerly fed a macrobiotic diet and in their counterparts. Methods: In this cross-sectional study bone mineral...article 2005
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Fredriks, A.M. (author), van Buuren, S. (author), van Heel, W.J.M. (author), Dijkman-Neerincx, R.H.M. (author), Verloove-Vanhorick, S.P. (author), Wit, J.M. (author), TNO Kwaliteit van Leven (author)Aims: To obtain age references for sitting height (SH), leg length (LL), and SH/H ratio in the Netherlands; to evaluate how SH standard deviation score (SDS), LL SDS, SH/H SDS, and SH/LL SDS are related to height SDS; and to study the usefulness of height corrected SH/H cut-off lines to detect Marfan syndrome and hypochondroplasia. Methods:...article 2005
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Lina, B.A.R. (author), Kuijpers, M.H.M. (author), TNO Voeding (author)The effects of diet-induced acid-base disturbances were examined in 4-week, 13-week and 18-month toxicity studies, and in a 30-month carcinogenicity study. Rats were fed a natural ingredient diet (controls), supplemented with 2% or 4% KHCO3 (base-forming diets), or with 1% or 2.1% NH4Cl (acid-forming diets). Additional controls were fed 3% KCl ...article 2004
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Delaney, B. (author), de Vogel, N. (author), Krul, C.A.M. (author), TNO Voeding (author)Chemicals / CAS: corn oil, 8001-30-7; mitomycin C, 50-07-7, 74349-48-7; Glucans; Mutagensarticle 2004
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Lindeman, J.H.N. (author), Hanemaaijer, R. (author), Mulder, A. (author), Dijkstra, P.D.S. (author), Szuhai, K. (author), Bromme, D. (author), Verheijen, J.H. (author), Hogendoorn, P.C.W. (author)Giant cell tumor (GCT) of bone is a neoplasm of bone characterized by a localized osteolytic lesion. The nature of GCT is an enigma and the cell type(s) and protease(s) responsible for the extensive localized clinicoradiological osteolysis remain unresolved. We evaluated protease expression and cellular distribution of the proteolytic machinery...article 2004
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van Rooij, L. (author), van Hoof, J. (author), Barbir, A. (author), van der Made, R. (author), Slaats, P.M.A. (author), McCann, M.J. (author), Ridella, S.A. (author), Rupp, J.D. (author), TNO Wegtransportmiddelen (author)Injuries to the knee-thigh-hip (KTH) complex in frontal motor vehicle crashes are of substantial concern because of their frequency and potential to result in long-term disability. Current frontal impact Anthropometric Test Dummies (ATDs) have been shown to respond differently than human cadavers under frontal knee impact loading and...conference paper 2004
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de Groot, J. (author)Accumulation of advanced glycation endproducts (AGEs) plays a crucial part in the development of age-related diseases and diabetic complications. AGEs are formed in vivo via the so-called Maillard reaction: a reducing sugar reacts with a protein to form a labile Amadori product that is subsequently stabilized, producing an irreversible, non...article 2004
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van der Harst, M.R. (author), Brama, P.A.J. (author), van de Lest, C.H.A. (author), Kiers, G.H. (author), de Groot, J. (author), van Weeren, P.R. (author), TNO Kwaliteit van Leven (author)Objective: In articular joints, the forces generated by locomotion are absorbed by the whole of cartilage, subchondral bone and underlying trabecular bone. The objective of this study is to test the hypothesis that regional differences in joint loading are related to clear and interrelated differences in the composition of the extracellular...article 2004
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Day, J.S. (author), van der Linden, J.C. (author), Bank, R.A. (author), Ding, M. (author), Hvid, I. (author), Sumner, D.R. (author), Weinans, H. (author), TNO Preventie en Gezondheid (author)Osteoarthritis is a chronic joint disease with pathological changes in the articulating cartilage and all other tissues that occupy the joint. Radin and coworkers have suggested the involvement of subchondral bone in the disease process. However, evidence for an essential role in the etiology has never been proven. Recent studies showing reduced...article 2004
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- Frölke, J.P.M. (author), Reeling Brouwer, G.C. (author), Giannoudis, P.V. (author) article 2004
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TNO Arbeid (author), Dekkers, J.C. (author), Podolsky, R.H. (author), Treiber, F.A. (author), Barbeau, P. (author), Gutin, B. (author), Snieder, H. (author)Background: Obesity is associated with multiple health problems, often originating in childhood. Objective: The objective was to investigate differences in the development of adiposity from childhood to adulthood as related to race, sex, and socioeconomic status (SES). Design: Individual growth curve modeling for waist circumference, body mass...article 2004
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TNO Preventie en Gezondheid (author), Ha-Vinh, R. (author), Alanay, Y. (author), Bank, R.A. (author), Campos-Xavier, A.B. (author), Zankl, A. (author), Superti-Furga, A. (author), Bonafé, L. (author)Bruck syndrome (BS) is a recessively-inherited phenotypic disorder featuring the unusual combination of skeletal changes resembling osteogenesis imperfects (OI) with congenital contractures of the large joints. Clinical heterogeneity is apparent in cases reported thus far. While the genes coding for collagen 1 chains are unaffected in BS, there...article 2004
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Gaubius Instituut TNO (author), van de Lest, C.H.A. (author), Brama, P.A.J. (author), van El, B. (author), de Groot, J. (author), van Weeren, P.R. (author)Osteochondrosis (OC) is the most important developmental orthopaedic disease in the horse. Despite some decades of research, much of the pathogenesis of the disorder remains obscure. Increasing knowledge of articular cartilage development in juvenile animals led to the presumption that the role of collagen in OC might be more important than...article 2004
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Dhonukshe-Rutten, R.A.M. (author), Lips, M. (author), de Jong, N. (author), Marijke, J.M.C.A.P. (author), Hiddink, G.J. (author), van Dusseldorp, M. (author), de Groot, L.C.P.G.M. (author), van Staveren, W.A. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)Subclinical vitamin B-12 deficiency is common in the elderly. Encouraged by early indications, we investigated the plasma vitamin B-12 status in association with bone mineral content (BMC) and bone mineral density (BMD) in frail elderly people. Data of 194 free-living Dutch frail elderly (143 women and 51 men) were available. BMC and BMD were...article 2003
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Tryfonidou, M.A. (author), Holl, M.S. (author), Stevenhagen, J.J. (author), Buurman, C.J. (author), Deluca, H.F. (author), Oosterlaken-Dijksterhuis, M.A. (author), van den Brom, W.E. (author), van Leeuwen, J.P.T.M. (author), Hazewinkel, H.A.W. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)The effects of excessive non-toxic dietary Vitamin D3 supplementation on Ca homeostasis with specific effects on endochondral ossification and skeletal remodeling were investigated in a group of growing Great Dane dogs supplemented with cholecalciferol (Vitamin D3; HVitD) versus a control group (CVitD) (1350 μg versus 11.4 μg Vitamin D3 per...article 2003