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van den Heuvel, E.G.H.M. (author), Muijs, T. (author), Brouns, F. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)Consumption of fructo-oligosaccharides (FOS) has been shown to improve mineral absorption in the short term, but no long-term effects were studied in girls with a low calcium intake. Therefore, we hypothesized that short- and long-term consumption of short-chain FOS (sc-FOS) improves calcium and magnesium absorption in girls with a low habitual...article 2009
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Brink, E. (author), Coxam, V. (author), Robins, S. (author), Wahala, K. (author), Cassidy, A. (author), Branca, F. (author), KvL (author)Background: Osteoporosis is a major health problem. It was hypothesized that isoflavone-containing products may be a potential alternative to hormone replacement therapy for preventing bone loss during the menopausal transition. Objective: The objective was to investigate whether the consumption of isoflavone-enriched foods for 1 y affects bone...article 2008
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Ainola, M. (author), Valleala, H. (author), Nykänen, P. (author), Risteli, J. (author), Hanemaaijer, R. (author), Konttinen, Y.T. (author), TNO Kwaliteit van Leven (author)Objective. The excellent poster painter Henri de Toulouse-Lautrec is the most famous patient with cathepsin K-deficient pycnodysostosis. Cathepsin K is believed to play a major role in osteoclast-driven bone resorption. In this study we explored the role of cathepsin K in bone resorption in a patient with a cathepsin K mutation causing...article 2008
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Budziszewski, P. (author), van Nunen, E. (author), Mordaka, J.K. (author), Kȩdzior, K. (author), TNO Industrie en Techniek (author)This paper describes the development of numerical model of human upper extremity able to perform movements and stabilization tasks in two degrees of freedom as a result of muscle activation controlled by a PID-based controller. These tasks are defined by functions of specified angle for every degree of freedom. Comparisons between model...conference paper 2008
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van Weel, V. (author), van Tongeren, R.B. (author), van Hinsbergh, V.W.M. (author), van Bockel, J.H. (author), Quax, P.H.A. (author), TNO Kwaliteit van Leven (author)Stimulation of vascular growth to treat limb ischemia is promising, and early results obtained from uncontrolled clinical trials using angiogenic agents, e.g., vascular endothelial growth factor, led to high expectations. However, negative results from recent placebo-controlled trials warrant further research. Here, current insights into...article 2008
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TNO Kwaliteit van Leven (author), Hunter, D.J. (author), LaValley, M. (author), Li, J. (author), Bauer, D.C. (author), Nevitt, M. (author), de Groot, J. (author), Poole, R. (author), Eyre, D. (author), Guermazi, A. (author), Gale, D. (author), Totterman, S. (author), Felson, D.T. (author)Introduction: Our objective was to determine whether markers of bone resorption and formation could serve as markers for the presence of bone marrow lesions (BMLs). Methods: We conducted an analysis of data from the Boston Osteoarthritis of the Knee Study (BOKS). Knee magnetic resonance images were scored for BMLs using a semiquantitative...article 2008
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TNO Kwaliteit van Leven (author), Chanteranne, B. (author), Branca, F. (author), Kardinaal, A. (author), Wahala, K. (author), Braesco, V. (author), Ladroite, P. (author), Brouns, F. (author), Coxam, V. (author)The estrogenic effects of soy isoflavones (IF) on symptoms of menopause are of particular interest. The aim of the present study was to improve compliance of IF in two IF-enriched foods providing the same IF circulating levels in postmenopausal women. Forty-two healthy postmenopausal women (mean age: 53.28 years) were recruited for a randomized,...article 2008
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TNO Kwaliteit van Leven (author), van den Bos, T. (author), Speijer, D. (author), Bank, R.A. (author), Bromme, D. (author), Everts, V. (author)The mammalian skeleton consists of bones that are formed in two different ways: long bones via endochondral ossification and flat bones via intramembranous ossification. These different formation modes may result in differences in the composition of the two bone types. Using the 2D-difference in gel electrophoresis technique and mass...article 2008
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Prado, M. (author), Berben, G. (author), Fumière, O. (author), van Duijn, G. (author), Mensinga-Kruize, J. (author), Reaney, S. (author), Boix, A. (author), von Holst, C. (author), TNO Kwaliteit van Leven (author)The commercialization of animal feeds infected by prions proved to be the main cause of transmission of bovine spongiform encephalopathy (BSE). Therefore, feed bans were enforced, initially for ruminant feeds, and later for all feeds for farmed animals. The development and validation of analytical methods for the species-specific detection of...article 2007
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Meulenbelt, I. (author), Kloppenburg, M. (author), Kroon, H.M. (author), Houwing-Duistermaat, J.J. (author), Garnero, P. (author), Hellio-Le Graverand, M.-P. (author), de Groot, J. (author), Slagboom, P.E. (author), TNO Kwaliteit van Leven (author)Objective: To assess the relationship of biochemical markers and radiographic signs of osteoarthritis (ROA) in the subjects with symptomatic osteoarthritis (OA) at multiple sites of the Genetics osteoARthritis and Progression (GARP) study. Methods: We have measured eight biochemical markers, representing tissue turnover of cartilage, bone,...article 2007
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Zuiderwijk-Sick, E.A. (author), van der Putten, C. (author), Bsibsi, M. (author), Deuzing, I.P. (author), de Boer, W. (author), Persoon-Deen, C. (author), Kondova, I. (author), Boven, L.A. (author), van Noort, J.M. (author), 't Hart, B.A. (author), Amor, S. (author), Bajramovic, J.J. (author), TNO Defensie en Veiligheid TNO Kwaliteit van Leven (author)Activated microglia are found in a variety of neuroinflammatory disorders where they have attributed roles as effector as well as antigen-presenting cells (APC). Critical determinants for the multifaceted role of microglia are the differentiation potential of microglia and their mode of activation. In this study, we have investigated the effects...article 2007
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Westerterp, M. (author), van Eck, M. (author), de Haan, W. (author), Offerman, E.H. (author), van Berkel, T.J.C. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), TNO Kwaliteit van Leven (author)Objective: Apolipoprotein CI (apoCI) is expressed in the liver and in macrophages, and has several roles in lipid metabolism. Since macrophage apoCI expression might affect macrophage lipid homeostasis and atherosclerotic lesion development locally in the arterial wall, we investigated the effect of both systemic and macrophage apoCI on...article 2007
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van Bezooijen, R.L. (author), Svensson, J.P. (author), Eefting, D. (author), Visser, A. (author), van der Horst, G. (author), Karperien, M. (author), Quax, P.H.A. (author), Vrieling, H. (author), Papapoulos, S.E. (author), ten Dijke, P. (author), Löwik, W.G.M.C. (author), TNO Kwaliteit van Leven (author)Sclerostin is an osteocyte-derived negative regulator of bone formation. It inhibits BMP-stimulated bone formation both in vitro and in vivo but has no direct effect on BMP signaling. Instead, sclerostin inhibits Wnt signaling that is required for BMP-stimulated osteoblastic differentiation. Introduction: Sclerostin is a member of the Dan family...article 2007
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Valstar, D.L. (author), Schijf, M.A. (author), Arts, J.H.E. (author), Kuper, C.F. (author), Nijkamp, F.P. (author), Storm, G. (author), Bloksma, N. (author), Henricks, P.A.J. (author), TNO Kwaliteit van Leven (author)Occupational exposure to low molecular weight chemicals, like trimellitic anhydride (TMA), can result in occupational asthma. Alveolar macrophages (AMs) are among the first cells to encounter these inhaled compounds and were previously shown to affect TMA-induced asthma-like symptoms in the Brown Norway rat (Valstar et al., Toxicol. Appl....article 2006
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Mandelin, J. (author), Hukkanen, M. (author), Li, T.F. (author), Korhonen, M. (author), Liljeström, M. (author), Sillat, T. (author), Hanemaaijer, R. (author), Salo, J. (author), Santavirta, S. (author), Konttinen, Y.T. (author), TNO Kwaliteit van Leven (author)Healthy bone is a rigid yet living tissue that undergoes continuous remodeling. Osteoclasts resorb bone in the remodeling cycle. They secrete H+-ions and proteinases to dissolve bone mineral and degrade organic bone matrix, respectively. One of the main collagenolytic proteinase in osteoclasts is cathepsin K, a member of papain family cysteine...article 2006
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van Hinsbergh, V.W.M. (author), Engelse, M.A. (author), Quax, P.H.A. (author), TNO Kwaliteit van Leven (author)Pericellular proteases play an important role in angiogenesis and vasculogenesis. They comprise (membrane-type) matrix metalloproteinases [(MT-)MMPs], serine proteases, cysteine cathepsins, and membrane-bound aminopeptidases. Specific inhibitors regulate them. Major roles in initiating angiogenesis have been attributed to MT1-matrix...article 2006
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Mulder, S.J. (author), Mulder-Bos, G.C. (author), TNO Kwaliteit van Leven (author)Coeliac disease frequency increases by obscure reasons and affects in some Western countries as much as 1% of the populations. The second one of monozygotic twins does not develop the disease in 100% but only in 20-50%. To unravel these mysteries, literature was searched to determine the disease background and find suggestions for research and...article 2006
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van den Akker-van Marle, M.E. (author), Gurwitz, D. (author), Detmar, S.B. (author), Enzing, C.M. (author), Hopkins, M.M. (author), Gutierrez De Mesa, E. (author), Ibarreta, D. (author), TNO Kwaliteit van Leven (author)Only a few studies have addressed the cost-effectiveness of pharmacogenetics interventions in healthcare. Lack of health economics data on aspects of pharmacogenetics is perceived as one of the barriers hindering its implementation for improving drug safety. Thus, a recent Institute for Prospective Technological Studies (IPTS) study, entitled ...article 2006
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TNO Kwaliteit van Leven (author), Silva, M.J. (author), Brodt, M.D. (author), Wopenka, B. (author), Thomopoulos, S. (author), Williams, D. (author), Wassen, M.H.M. (author), Ko, M. (author), Kusano, N. (author), Bank, R.A. (author)To examine the link between bone material properties and skeletal fragility, we analyzed the mechanical, histological, biochemical, and spectroscopic properties of bones from a murine model of skeletal fragility (SAMP6). Intact bones from SAMP6 mice are weak and brittle compared with SAMR1 controls, a defect attributed to reduced strength of the...article 2006
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Lin, Y.L. (author), Brama, P.A.J. (author), Kiers, G.H. (author), van Weeren, P.R. (author), de Groot, J. (author), TNO Preventie en Gezondheid (author)The objectives of the present study were to test the hypotheses that: (1) the composition of the extracellular matrix of the equine superficial digital flexor tendon (SDFT) shows great functional similarities with articular cartilage, i.e. that significant differences exist in biochemical composition of differently loaded areas (which in the...article 2005