Searched for: subject:"alpha%5C+tocopherol"
(1 - 20 of 41)

Pages

document
van den Broek, T.J. (author), Kremer, B.H.A. (author), marcondes Rezende, M. (author), Hoevenaars, F.P.M. (author), Weber, P. (author), Hoeller, U. (author), van Ommen, B. (author), Wopereis, S. (author)
Background. Vitamins and carotenoids are key micronutrients facilitating the maintenance of health, as evidenced by the increased risk of disease with low intake. Optimal phenotypic flexibility, i.e., the ability to respond to a physiological challenge, is an essential indicator of health status. Therefore, health can be measured by applying a...
article 2017
document
Raiten, D.J. (author), Sakr Ashour, F.A. (author), Ross, A.C. (author), Meydani, S.N. (author), Dawson, H.D. (author), Stephensen, C.B. (author), Brabin, B.J. (author), Suchdev, P.S. (author), van Ommen, B. (author), Ahluwalia, N. (author), Ahmed, T. (author), Allen, L. (author), Beck, M. (author), Blanchard, H. (author), Brindle, E. (author), Brown, K. (author), Calder, P. (author), Checkley, W. (author), Claycombe, K. (author), Coles, C. (author), Esamai, F. (author), Friis, H. (author), Gardner, E. (author), Grinspoon, S. (author), Guerrant, R. (author), Hellerstein, M. (author), Hunt, J. (author), King, J. (author), Klasing, K. (author), Kramer, B. (author), Koski, K. (author), Northrop-Clewes, C. (author), Pfeiffer, C. (author), Prentice, A. (author), Ramirez-Zea, M. (author), van Rheenan, P. (author), Rink, L. (author), Srinivasa, S. (author), Benn, C.S. (author), Stephensen, C. (author), Suchdev, P. (author), Sullivan, K. (author), Thurnham, D. (author), Varadhan, R. (author), Van Der Ven, A. (author), Walston, J. (author), Xia, J. (author)
An increasing recognition has emerged of the complexities of the global health agenda-specifically, the collision of infections and noncommunicable diseases and the dual burden of over- and undernutrition. Of particular practical concern are both 1) the need for a better understanding of the bidirectional relations between nutritional status and...
article 2015
document
Verschuren, L. (author), Wielinga, P.Y. (author), van Duyvenvoorde, W. (author), Tijani, S. (author), Toet, K. (author), van Ommen, B. (author), Kooistra, T. (author), Kleemann, R. (author)
Chronic inflammation and proatherogenic lipids are important risk factors of cardiovascular disease (CVD). Specific dietary constituents such as polyphenols and fish oils may improve cardiovascular risk factors and may have a beneficial effect on disease outcomes. We hypothesized that the intake of an antiinflammatory dietary mixture (AIDM)...
article 2011
document
van Dijk, B.A.C. (author), Schouten, L.J. (author), Oosterwijk, E. (author), Kaa, C.A. (author), Kiemeney, L.A.L.M. (author), Goldbohm, R.A. (author), Schalken, J.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Objective: We investigated whether dietary carotenoid and vitamin intake and supplemental vitamin use were inversely associated with RCC risk and with Von Hippel-Lindau (VHL)-gene mutations in clear-cell renal cell carcinoma (RCC). Methods: The Netherlands Cohort Study on diet and cancer (NLCS) includes 120,852 persons, who completed a self...
article 2008
document
TNO Kwaliteit van Leven (author), van Ommen, B. (author), Fairweather-Tait, S. (author), Freidig, A. (author), Kardinaal, A. (author), Scalbert, A. (author), Wopereis, S. (author)
Micronutrients are involved in specific biochemical pathways and have dedicated functions in the body, but they are also interconnected in complex metabolic networks, such as oxidative-reductive and inflammatory pathways and hormonal regulation, in which the overarching function is to optimise health. Post-genomic technologies, in particular...
article 2008
document
Gibbs, S. (author), van de Sandt, J.J.M. (author), Merk, H.F. (author), Lockley, D.J. (author), Pendlington, R.U. (author), Pease, C.K. (author), TNO Kwaliteit van Leven (author)
In this review, we discuss and compare studies of xenobiotic metabolism in both human skin and 3D human skin reconstructs. In comparison to the liver, the skin is a less studied organ in terms of characterising metabolic capability. While the skin forms the major protective barrier to environmental chemical exposure, it is also a potential...
article 2007
document
Slimani, N. (author), Deharveng, G. (author), Unwin, I. (author), Southgate, D.A.T. (author), Vignat, J. (author), Skeie, G. (author), Salvini, S. (author), Parpinel, M. (author), Møller, A. (author), Ireland, J. (author), Becker, W. (author), Farran, A. (author), Westenbrink, S. (author), Vasilopoulou, E. (author), Unwin, J. (author), Borgejordet, Å. (author), Rohrmann, S. (author), Church, S. (author), Gnagnarella, P. (author), Casagrande, C. (author), van Bakel, M. (author), Niravong, M. (author), Boutron-Ruault, M.C. (author), Stripp, C. (author), Tjønneland, A. (author), Trichopoulou, A. (author), Georga, K. (author), Nilsson, S. (author), Mattisson, I. (author), Ray, J. (author), Boeing, H. (author), Ocké, M. (author), Peeters, P.H.M. (author), Jakszyn, P. (author), Amiano, P. (author), Engeset, D. (author), Lund, E. (author), Santucci de Magistris, M. (author), Sacerdote, C. (author), Welch, A. (author), Bingham, S. (author), Subar, A.F. (author), Riboli, E. (author), TNO Kwaliteit van Leven (author)
Objective: This paper describes the ad hoc methodological concepts and procedures developed to improve the comparability of Nutrient databases (NDBs) across the 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). This was required because there is currently no European reference NDB...
article 2007
document
Zeegers, M.P. (author), Selen, R.F.M. (author), Kleinjans, J.C.S. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Objectives: N-nitroso compounds, endogenously formed from nitrate-derived nitrite, are suspected to be important bladder carcinogens. However, the association between nitrate exposure from food or drinking water and bladder cancer has not been substantially investigated in epidemiologic studies. Methods: We evaluated the associations between...
article 2006
document
van den Brandt, P.A. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven (author)
Diet has been hypothesized to play a role in the etiology of gastrointestinal cancer for a long time. Initially, strong evidence of such effects was found in retrospective epidemiological studies. Dietary habits, in particular those from the distant past, are difficult to measure, however. Results from recent, prospective and larger studies of...
article 2006
document
Cho, E. (author), Hunter, D.J. (author), Spiegelman, D. (author), Albanes, D. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Colditz, G.A. (author), Feskanich, D. (author), Folsom, A.R. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Miller, A.B. (author), Rohan, T.E. (author), Sellers, T.A. (author), Virtamo, J. (author), Willett, W.C. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)
Intakes of vitamins A, C and E and folate have been hypothesized to reduce lung cancer risk. We examined these associations in a pooled analysis of the primary data from 8 prospective studies from North America and Europe. Baseline vitamin intake was assessed using a validated food-frequency questionnaire, in each study. We calculated study...
article 2006
document
Männistö, S. (author), Dixon, L.B. (author), Balder, H.F. (author), Virtanen, M.J. (author), Krogh, V. (author), Khani, B.R. (author), Berrino, F. (author), van den Brandt, P.A. (author), Hartman, A.M. (author), Pietinen, P. (author), Tan, F. (author), Wolk, A. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven TNO Voeding (author)
Objective: Only a few consistent findings on individual foods or nutrients that influence breast cancer risk have emerged thus far. Since people do not consume individual foods but certain combinations of them, the analysis of dietary patterns may offer an additional aspect for assessing associations between diet and diseases such as breast...
article 2005
document
Dagnelie, P.C. (author), Schuurman, A.G. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding (author)
We reviewed 37 prospective cohort and four intervention studies on potential dietary risk factors for prostate cancer, published between 1966 and September 2003. Some studies were limited by small size, crude measurement of dietary exposure and limited control for confounders. Intervention and prospective cohort studies support a protective role...
article 2004
document
Post, S.M. (author), Groenendijk, M. (author), Solaas, K. (author), Rensen, P.C.N. (author), Princen, H.M.G. (author), TNO Preventie en Gezondheid (author)
Objective-Cholesterol 7α-hydroxylase (cyp7a1) catalyzes the rate-limiting step in conversion of cholesterol to bile acids. To study the relationship between bile acid biosynthesis and triglyceride metabolism, we cross-bred mice lacking cyp7a1 on a hyperlipidemic APOE*3-Leiden background. Methods and Results-Female mice received a chow or...
article 2004
document
van Herpen-Broekmans, W. (author), Klöpping-Ketelaars, I. (author), Michiel, B. (author), Cornelis, K. (author), Hans, P. (author), Hendriks, F.J. (author), Tijburg, L. (author), van Poppel, G. (author), Kardinaal, A. (author), TNO Preventie en Gezondheid (author)
Background: Endothelial cell dysfunction may be related to an increase in cellular oxidative stress. Carotenoids and vitamins could have an antioxidant-mediated tempering influence on endothelial function and inflammation, thereby reducing the risk of atherosclerosis. Methods: We measured serum carotenoids, α-tocopherol and Vitamin C...
article 2004
document
Dommels, Y.E.M. (author), Haring, M.M.G. (author), Keestra, N.G.M. (author), Alink, G.M. (author), van Bladeren, P.J. (author), van Ommen, B. (author)
This study was conducted to investigate the role of the enzyme cyclooxygenase (COX) and its prostaglandin product PGE2 in n-6 and n-3 polyunsaturated fatty acid (PUFA)-mediated effects on cellular proliferation of two human colorectal carcinoma cell lines. The long chain PUFAs eicosapentaenoic acid (EPA; 20:5n-3) and arachidonic acid (AA; 20:4n...
article 2003
document
Balder, H.F. (author), Virtanen, M. (author), Brants, H.A.M. (author), Krogh, V. (author), Dixon, L.B. (author), Tan, F. (author), Mannisto, S. (author), Bellocco, R. (author), Pietinen, P. (author), Wolk, A. (author), Berrino, F. (author), van den Brandt, P.A. (author), Hartman, A.M. (author), Goldbohm, R.A. (author)
The association between diet and cancer, predominantly investigated univariately, has often been inconsistent, possibly because of the large number of candidate risk factors and their high intercorrelations. Analysis of dietary patterns is expected to give more insight than analysis of single nutrients or foods. This study aimed to develop and...
article 2003
document
Broekmans, W.M.R. (author), Klöpping-Ketelaars, I.A.A. (author), Weststrate, J.A. (author), Tijburg, L.B.M. (author), van Poppel, G. (author), Vink, A.A. (author), Berendschot, T.T.J.M. (author), Bots, M.L. (author), Castenmiller, W.A.M. (author), Kardinaal, A.F.M. (author)
Excessive consumption of energy and fat increases the risk for obesity. Snacks containing sucrose polyesters (SPE) as a dietary fat replacer are on the market in the United States. SPE products have been shown to lower concentrations of serum carotenoids in short-term studies. Experimental studies on the longer-term effects on health of...
article 2003
document
Broekmans, W.M.R. (author), Vink, A.A. (author), Boelsma, E. (author), Klöpping-Ketelaars, W.A.A. (author), Tijburg, L.B.M. (author), van 't Veer, P. (author), van Poppel, G. (author), Kardinaal, A.F.M. (author), TNO Voeding (author)
Background: Acute effects of UV irradiation include UV-induced erythema. Sunlight plays an important role in the development of skin cancer. Several predictive factors of UV-induced erythema could also be predictive for skin cancer. Objective: Our objective was to quantitatively assess phenotypical and nutritional determinants of sensitivity to...
article 2003
document
Rhodes, L.E. (author), Shahbakhti, H. (author), Azurdia, R.M. (author), Moison, R.M.W. (author), Steenwinkel, M.J.S.T. (author), Homburg, M.I. (author), Dean, M.P. (author), McArdle, F. (author), Beijersbergen van Henegouwen, G.M.J. (author), Epe, B. (author), Vink, A.A. (author)
Dietary omega-3 polyunsaturated fatty acids (ω-3 PUFAs) protect against photocarcinogenesis in animals, but prospective human studies are scarce. The mechanism(s) underlying the photoprotection are uncertain, although ω-3 PUFAs may influence oxidative stress. We examined the effect of supplementation on a range of indicators of ultraviolet...
article 2003
document
van den Brandt, P.A. (author), Zeegers, M.P.A. (author), Bode, P. (author), Goldbohm, R.A. (author)
Results of a randomized controlled trial have suggested a protective effect of selenium against prostate cancer. Few other prospective studies have been conducted to confirm or refute this. The association between prostate cancer and baseline toenail selenium level was evaluated in the Netherlands Cohort Study, conducted among 58,279 men, aged...
article 2003
Searched for: subject:"alpha%5C+tocopherol"
(1 - 20 of 41)

Pages