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- Radiobiologisch Instituut TNO (author), Hermens, A.F. (author), Korving, R. (author), de Leeuw, A.M. (author), van den Berg, K.J. (author) article 1986
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CIVO Centraal instituut voor voedingsonderzoek TNO Werkgroep biomedische instrumentatie TNO (author), Langewouters, G.J. (author), Zwart, A. (author), Busse, R. (author), Wesseling, K.H. (author)Pressure-diameter relationships of segments of human finger arteries, aged 57-85 years, were measured in vitro. The arteries, obtained at autopsy within 48 h after death, were stored in glucose-free Tyrode at 4 degrees C. Experiments began within 40 h after autopsy. The diameter responses to various transmural pressure changes, with and without...article 1986
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D'Angelo, A. (author), Kluft, C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)In nine patients with non-malignant diseases undergoing major upper abdominal surgery, the mechanism of the postoperative fibrinolytic shut-down was investigated because of its potential significance for postoperative deep vein thrombosis by employing new and specific methods for assessing and stimulating the fibrinolytic system. The shut-down...article 1985
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Horbach, G.J.M.J. (author), Princen, H.M.G. (author), van der Kroef, M. (author), van Bezooijen, C.F.A. (author), Yap, S.H. (author)To investigate the regulation of age-related changes in albumin synthesis in the rat liver, total postnuclear RNA and polyribosomes, both membrane-bound and free, were prepared from livers of rats of different ages. By the use of a specific complementary DNA probe, the albumin mRNA sequence content was quantitated in these RNA fractions. These...article 1984
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- Kooijman, S.A.L.M. (author), Metz, J.A.J. (author), Hoofdgroep Maatschappelijke Technologie TNO Centraal Laboratorium TNO (author) article 1984
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- Tans, J.T.J. (author), Poortvliet, D.C.J. (author), Instituut voor Gezondheidstechniek TNO Medisch Biologisch Laboratorium TNO (author) article 1984
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Vaandrager, G.J. (author), Bruining, G.J. (author), Veenhof, F.J. (author), Drayer, N.M. (author), TNO Preventie en Gezondheid (author)The incidence of childhood diabetes (0-19 years of age) in The Netherlands, where there is no nationalized health-care system, was investigated retrospectively in the years 1978 to 1980 inclusive. The method chosen was a questionnaire among all Dutch paediatricians and internal physicians acting as consultants. Ascertainment was by the same...article 1984
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Instituut CIVO-Toxicologie en Voeding TNO (author), Schrijver, J. (author), van Rijn, H.J.M. (author), Schreurs, W.H.P. (author)The reference values of the three main types of serum haptoglobin Hp 1-1, Hp 2-1, and Hp 2-2, as determined by radial immunodiffusion and with phenotype determination on polyacrylamide gel electrophoresis have been re-evaluated for both sexes. For that purpose about 500 serum samples were collected from normal, healthy Dutch volunteers. The...article 1984
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Instituut voor experimentele gerontologie TNO (author), Horbach, G.J.M.J. (author), Yap, S.H. (author), van Bezooijen, C.F.A. (author)Albumin elimination rates were determined in 3-, 12-, 24- and 36-month-old female WAG/Rij rats. No change in elimination half-life was found with age. However, as there was an increase in the whole-body albumin pool, a concomitant increase in albumin clearance was observed at between 12 and 36 months of age. It was concluded that the increase in...article 1983
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Instituut voor experimentele gerontologie TNO (author), Brouwer, A. (author), Knook, D.L. (author)This review represents an attempt to summarize and evaluate the literature data on the changes occurring in the reticuloendothelial system (RES) during aging. The RES is briefly introduced with emphasis on cellular composition, function, physiology, regulation and the methods employed for assessment of its functions. The age-related changes in...article 1983
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Instituut voor experimentele gerontologie TNO (author), van Bezooijen, C.F.A. (author), Sakkee, A.N. (author), Knook, D.L. (author)Protein-synthesizing activity was studied in hepatocytes isolated from rats of various ages with or without treatment with 80 mg meclofenoxate/day per kg body weight for 2 weeks. The substance did not influence protein synthesis in hepatocytes isolated from 3- and 12-month-old rats, but drastically decreased the synthesis of protein by...article 1983
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Brommer, E.J.P. (author), Leuven, J.A.G. (author), Barrett-Bergshoeff, M.M. (author), Schouten, J.A. (author), Gaubius instituut TNO (author)Impairment of fibrinolysis is supposed to contribute to CVD. In 38 hyperlipoproteinemic patients, known to be at risk for early CVD, fibrinolytic activity was measured before and after stimulation with DDAVP. A negative correlation was found between serum triglyceride levels and fibrinolytic activity, both before and after DDAVP. A subnormal...article 1982
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Instituut voor experimentele gerontologie TNO (author), Kitani, K. (author), Sato, Y. (author), van Bezooijen, K. (author)The biliary excretion of digitoxin (Dt3) and its metabolites was studied in female BN/Bi rats of different ages ranging from 3 to 30 mth. The disappearance of radioactivity from plasma after an i.v. injection of [3H]Dt3 (0.01 mg/100 g body weight) gradually slowed as rat age advanced. The 2-h biliary recovery of radioactivity (percent of the...article 1982
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Ponsen, L. (author), Jonkman, E.J. (author), TNO Res. Unit Clin. Neurophysiol., c/o Westeinde Hosp., 2512 VA The Hague, Netherlands Medisch Biologisch Laboratorium TNO (author)Part I of this article reviewed aetiological and clinical phenomena related to the Creutzfeldt-Jakob disease. A case history of one patient was presented together with some electro-encephalographic aspects in relation to this disease and results of computer analysis of the EEG. The slow virus concept and its implications for treatment of...article 1981
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Nooijen, W.J. (author), Koppert, P.W. (author), Gaubius instituut TNO (author)A specific glucagon antiserum was generated in rabbits using a derivatisation of the methionine residue in glucagon. A sensitive and specific assay for glucagon has been developed. Interference with the assay system by plasma factors was abolished by both extraction of plasma samples and the production of glucagon-free plasma for each individual...article 1981
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Wolthuis, O. (author), Vanwersch, R.A.P. (author), van der Wiel, H.J. (author), Medisch Biologisch Laboratorium TNO (author)Previous results had shown that bis-pyridinium oximes, particularly HI-6 are quite effective therapeutically in soman-poisoned rats and mice in vivo and in the rat diaphragm preparation in vitro. The aim of the present study was to investigate the efficacy of bis-pyridinium oximes on soman-inhibited neuromuscular transmission in muscle...article 1981
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Gaubius Instituut TNO (author), Havekes, L. (author), Vermeer, B.J. (author), Brugman, T. (author), Emeis, J. (author)Chemicals/CAS: Lipoprotein(a); Lipoproteins; Lipoproteins, LDL; Receptors, Cell Surface; Receptors, LDLarticle 1981
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Kruisbeek, A.M. (author), Steinmeier, F.A. (author), Instituut voor experimentele gerontologie TNO (author)Much data support the notion that with increasing age a decline in T cell effector function occurs. In the present study, qualitative rather than quantitative age-related changes in vitro alloreactive cytotoxic T lymphocyte (CTL) responses were observed. The level of specific alloreactive CTL responses was not consistently lower in aged mice,...article 1980
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Meihuizen, S.P. (author), Blansjaar, N. (author), Instituut voor experimentele gerontologie TNO (author)Hepatocyte morphology of the three zones of the liver lobule was evaluated by stereological analysis in 3-month-old and 35-month-old virgin female WAG/Rij rats. In the old rats, the volume of the nucleus and cytoplasm, and volume densities of smooth endoplasmic reticulum and lysosomes were increased in all areas of the liver lobule, while the...article 1980
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de Koning-Verest, I.F. (author), Medisch Biologisch Laboratorium TNO (author)The metabolism of glutamate, taken as an index of the metabolic state of the brain, was studied in brains of 3-, 12- and 30-month-old rats. Following the injection of a mixture of [3H]acetate and d-[2-14C]glucose, the brain levels of glutamate and aspartate were decreased in 30-month-old rats when compared with those of 3-month-old rats. No...article 1980