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TNO Preventie en Gezondheid (author), Herngreen, W.P. (author), van Buuren, S. (author), van Wieringen, J.C. (author), Reerink, J.D. (author), Verloove-Vanhorick, S.P. (author), Ruys, J.H. (author)Of nearly 1900 live-born singletons, born from April 1988 to October 1989 inclusive, nine measurements of length and weight have been taken between the ages of 1 and 24 months. In the first part of the study, differences in attained length and weight at 1 and 2 years of age are analysed according to socioeconomic status (SES). Multiple...article 1994
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de Vries, A.C.J. (author), Vermeer, M.A. (author), Bredman, J.J. (author), Bar, P.R. (author), Cohen, L.H. (author), Instituut voor verouderings- en vaatziekten onderzoek TNO (author)The influence of the 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors pravastatin and simvastatin on lens cholesterol metabolism was investigated in the rat. Short-term organ culture experiments with explanted lenses from 21-day-old Wistar rats showed that simvastatin was at least 35 times more effective than pravastatin in...article 1993
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Buitendijk, S.E. (author), van Enk, A. (author), Oosterhout, R. (author), Ris, M. (author), TNO Preventie en Gezondheid (author)The objective was to compare the course of teenage pregnancies and deliveries with those of women between the ages of 20 and 29, using data from the 1989 National Obstetric Database (LVR) when approximately 76% of cases conducted by obstetricians were registered. 4500 teenage pregnancies were studied to compare the risk of preterm birth, low...article 1993
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- Verloove-Vanhorick, S.P. (author), TNO Preventie en Gezondheid (author) article 1993
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Walraven, J. (author), Janzen, P. (author)In this investigation, carried out under a Youth Health Care postgraduate course in Nijmegen, the stereopsis of a school population of 730 children, aged 4-18 years, was recorded and clinically evaluated. Stereopsis was measured using the TNO test, a random-dot stereo test especially designed for the early detection of amblyopia. The main aims...article 1993
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TNO Biomedical Instrumentation (author), Wesseling, K.H. (author), Jansen, J.R.C. (author), Settels, J.J. (author), Schreuder, J.J. (author)We computed aortic flow pulsations from arterial pressure by simulating a nonlinear, time-varying three-element model of aortic input impedance. The model elements represent aortic characteristic impedance, arterial compliance, and systemic vascular resistance. Parameter values for the first two elements were computed from a published, age...article 1993
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Treurniet, H.F. (author), Davidse, W. (author)Objective - To present general trends in sexually transmitted disease (STD) in the Netherlands during the period 1984-1990 and to describe characteristics of the patients in order to get insight into possible factors underlying these trends. Methods - Since 1984 patients diagnosed with STD visiting STD clinics and local public health services in...article 1993
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de Vries, A.C.J. (author), Cohen, L.H. (author), Gaubius Laboratory IVVO-TNO, P.O. Box 430, 2300 AK Leiden, Netherlands Instituut voor verouderings- en vaatziekten onderzoek TNO (author)This study aimed to investigate the influence of the hypocholesterolemic drugs pravastatin and lovastatin on the cholesterol biosynthesis in the ocular lens. Two model systems were used: a human lens organ culture system and an in vivo rat lens system. For measurements of cholesterol and fatty acid synthesis rates, human lenses were incubated...article 1993
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Korteling, J.E. (author)When a dual-tracking task, consisting of two incoherent (uncorrelated) subtasks is partly integrated, such that it is characterized by incompatibility of similarity, or when axis similarity of subtasks is high, it may be difficult to map subtask stimuli to the proper responses. Especially for older adults, an increase in mapping demands may be a...article 1993
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- Gaubius instituut Instituut voor experimentele gerontologie TNO (author), Slagboom, P.E. (author) doctoral thesis 1993
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- TNO Technische Menskunde (author) conference paper 1993
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Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author), Esbach, S. (author), Pieters, M.N. (author), van der Boom, J. (author), Schouten, D. (author), van der Heyde, M.N. (author), Roholl, P.J.M. (author), Brouwer, A. (author), van Berkel, T.J.C. (author), Knook, D.L. (author)The interaction of oxidized human low-density lipoproteins with human and rat liver was analyzed by light and electron microscopy. At the light microscopic level oxidized low-density lipoprotein was visualized by the fluorescent dye 1,1' dioctadecyl 3,3,3',3' tetramethyl indocarbocyanine perchlorate, whereas at the electron microscopic level, an...article 1993
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- TNO Preventie en Gezondheid (author), Verloove-Vanhorick, S.P. (author) article 1993
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Gezondheidsorganisatie TNO Instituut voor verouderings- en vaatziekten onderzoek TNO (author), HogenEsch, H. (author), Niewold, T.A. (author), Higuchi, K. (author), Tooten, P.C.J. (author), Gruys, E. (author), Radl, J. (author)The light microscopic and immunohistochemical features of a novel localized senile amyloidosis in the gastrointestinal tract of C57BL/Ka mice are described. Senile gastrointestinal amyloidosis was predominantly found in the lamina propria of the ileum, cecum and stomach and infrequently in other segments of the gastrointestinal tract. The Congo...article 1993
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Centraal Instituut voor Voedingsonderzoek TNO (author), Kardinaal, A.F.M. (author), Kok, F.J. (author), Ringstad, J. (author), Gomez-Aracena, J. (author), Mazaev, V.P. (author), Kohlmeier, L. (author), Martin, B.C. (author), Aro, A. (author), Kark, J.D. (author), Delgado-Rodriguez, M. (author), Riemersma, R.A. (author), van 't Veer, P. (author), Huttunen, J.K. (author), Martin-Moreno, J.M. (author)Laboratory and epidemiological studies suggest that the antioxidants, vitamin E and β-carotene, protect against coronary heart disease. In a European multicentre case-control study α-tocopherol and β-carotene concentrations were measured in adipose-tissued samples collected in 1991-92 from 683 people with acute myocardial infarction and 727...article 1993
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Ens-Dokkum, M.H. (author), Schreuder, A.M. (author), Veen, S. (author), Verloove-Vanhorick, S.P. (author), Brand, R. (author), Ruys, J.H. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)Since the introduction of neonatal intensive care in the 1960s, mortality in very preterm and very low birthweight infants has been decreasing steadily. Consequently, interest in the outcome of surviving infants is growing. Restriction of health care resources has stressed the need for information concerning the effect of individual treatment...article 1992
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Haan, J. (author), Kluft, C. (author), Leebeek, F.W.G. (author), de Bart, A.C.W. (author), Buruma, O.J. (author), Roos, R.A.C. (author)In view of reported associations between increased bleeding tendency and systemically decreased alpha 2-antiplasmin in patients with systemic amyloid deposition we studied alpha 2-antiplasmin, fibrinogen, C-reactive protein and blood levels of locally produced endothelial hemostasis factors in the acute and quiescent phase in 16 patients with...article 1992
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- Radl, J. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author) article 1992
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van Loon, A.A.W.M. (author), Raadsheer, F.C. (author), Timmerman, A.J. (author), Haanen, C. (author), Wessels, J. (author), van der Schans, G.P. (author), Lohmans, P.H.M. (author), Baan, R.A. (author), Medisch Biologisch Laboratorium TNO (author)Chemotherapy combined with total-body irradiation (TBI), a conditioning regimen for bone-marrow transplantation (BMT), causes lesions in the cellular DNA of the patients treated. To understand possible consequences of the DNA damage induced during such treatment, information is required about the nature of the damage, the level of induction and...article 1992
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Brommer, E.J.P. (author), van Bockel, J.H. (author), Gaubius Laboratorium Instituut voor verouderings- en vaatziekten onderzoek TNO (author)Each of three distinct, concentric layers of human arterial thrombi, was analysed immunochemically for the plasminogen and fibrin content, and for the ex vivo susceptibility to thrombolysis by various thrombolytic agents in a saline or plasma milieu. The age of the thrombus layer determined: (a) the plasminogen content; (b) the fibrin content,...article 1992