- document
-
Theuns, H.M. (author), Offerman, E. (author), Blauw, B. (author), Hoven, P.v.d. (author), Bekker, H. (author), Roholl, P.J.M. (author), TNO Preventie en Gezondheid National Institute of Public Health and Environmental Protection (RIVM), Laboratory of Pathology, Netherlands (author)Ageing rats are more appropriate for studies on age-related osteopenia than growing or young adult rats, because of the better similarity with ageing man. Both have a negative bone balance, a low bone turnover, decreasing intestinal calcium absorption and decreasing levels of systemic hormones influencing the calcium and bone metabolism....article 1994
- document
-
Smits, R.C.F. (author), Emmen, H.H. (author), Bertelmans, F.W. (author), Kulig, B.M. (author), van Loenen, A.C. (author), Polman, C.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo- controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could...article 1994
- document
-
Kwan, A.L. (author), Verloove-Vanhorick, S.P. (author), Verwey, R.A. (author), Brand, R. (author), Ruys, J.H. (author), TNO Preventie en Gezondheid (author)Objective. To analyse whether the conventional so-called Kloosterman charts for birthweight of preterm infants based on data from 1931-1965 are still valid. Design. Descriptive investigation. Location. The Netherlands. Methods. Data were obtained from the 'project of the premature and small for gestational age' (POPS) survey in 1983. The...article 1994
- document
-
Slagboom, P.E. (author), Droog, S. (author), Boomsma, D.I. (author), TNO Preventie en Gezondheid (author)Reduction of telomere length has been postulated to be a causal factor in cellular aging. Human telomeres terminate in tandemly arranged repeat arrays consisting of the (TTAGGG) motif. The length of these arrays in cells from human mitotic tissues is inversely related to the age of the donor, indicating telomere reduction with age. In addition...article 1994
- document
-
Kampman, E. (author), Bijl, A.J. (author), Kok, C. (author), van 't Veer, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)We analysed data from a case-control study in the Netherlands in order to investigate whether reproductive events and hormonal factors are similarly related to colon cancer risk in men and women after adjustment for dietary factors. In total, 232 colon cancer cases (102 women, 130 men) and 259 controls (123 women, 136 men) were interviewed about...article 1994
- document
-
Goldbohm, R.A. (author), van den Brandt, P.A. (author), van 't Veer, P. (author), Dorant, E. (author), Sturmans, F. (author), Hermus, R.J.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)The association between alcohol consumption and cancer of the colon and rectum was investigated in a prospective cohort study, conducted in the Netherlands from 1986 onwards among 120,852 men and women, aged 55 to 69 years. During 3.3 years of follow-up, 312 and 166 cases of colon and rectal cancer had accumulated, respectively. After exclusion...article 1994
- document
-
Ruwaard, D. (author), Hirasing, R.A. (author), Reeser, H.M. (author), van Buuren, S. (author), Barker, K. (author), Heine, R.J. (author), Geerdink, R.A. (author), Bruining, G.J. (author), Vaandrager, G.J. (author), Verloove-Vanhorick, S.P. (author), TNO Preventie en Gezondheid (author)OBJECTIVE - A nationwide retrospective study was conducted to assess the incidence of type 1 diabetes in The Netherlands among children <20 years of age in 1988-1990. The first study with a similar design covered 1978-1980. RESEARCH DESIGN AND METHODS - The capture-recapture census method was chosen for analysis of the data. A questionnaire was...article 1994
- document
-
Groen, K. (author), Breimer, D.D. (author), Jansen, E.J. (author), van Bezooijen, C.F.A. (author), Gaubius Instituut TNO (author)The influence of aging on the metabolism of antipyrine (AP) and hexobarbital enantiomers (R-HB and S-HB) with and without phenobarbital (PB) induction was investigated in a longitudinal study in rats aged 6, 12, 24 and 30 months. The metabolic clearances of AP (Cl(m AP)), R-HB (Cl(m R-HB)) and S-HB (Cl(m S-HB)) were used as indicators for P450...article 1994
- document
-
Hille, E.T.M. (author), den Ouden, A.L. (author), Bauer, L. (author), van den Oudenrijn, C. (author), Brand, R. (author), Verloove-Vanhorick, S.P. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)To assess the impact of both perinatal disorders and developmental problems identified at preschool age on school performance, we followed a virtually complete birth cohort of very premature (<32 completed weeks of gestation) and very low birth weight infants until they were 9 years of age. In 84% of the survivors (n = 813), data on school...article 1994
- document
-
Hirasing, R.A. (author), Reus, H. (author), TNO Preventie en Gezondheid (author)Good long-term results of dry bed training of children with nocturnal enuresis. Objective. To determine the long-term effect of dry bed training in a youth health care setting. Setting. Haarlemmermeer, the Netherlands.Design. Descriptive. Method. Parents of 36 children (mean age 9 year) subjected to dry bed training in 1987-1989, were asked in...article 1994
- document
-
Velthuis-te Wierik, E.J.M. (author), Hoogzaad, L.V. (author), van den Berg, H. (author), Schaafsma, G. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)Energy restriction (ER) has shown to be an effective 'anti-aging' factor in rodents, resulting in an increased life span and preventing or delaying the occurrence of many age-related diseases in rodents. As a part of a feasibility study on the potential application of ER in humans, we studied the effects of moderate ER on physical performance in...article 1994
- document
-
Verkerk, P.H. (author), Buitendijk, S.E. (author), Verloove-Vanhorick, S.P. (author)Background. The validity of the results of studies using retrospectively collected information on exposures is often criticized, because cases may report differently from controls even if their true exposure status is the same. This study was performed to quantify the extent to which this effect (differential misclassification) may occur for...article 1994
- document
-
Nijhuis, E. (author), Hinloopen, B. (author), van Duijn, C. (author), Hofman, A. (author), Rozing, J. (author), Nagelkerken, L. (author), Section of Immunology, Inst. of Aging and Vascular Research, TNO, Leiden, Netherlands TNO Preventie en Gezondheid (author)Cortisol levels in patients with Alzheimer's disease (AD) are relatively unaffected by a challenge with dexamethasone (DEX) in vivo. The present study demonstrates that DEX is less inhibitory for phytohemagglutinin (PHA)-induced T cell proliferation in AD patients as compared to age-matched controls. Since no significant differences were found...article 1994
- document
-
Verkerk, P.H. (author), Zaadstra, B.M. (author), Reerink, J.D. (author), Herngreen, W.P. (author), Verloove-Vanhorick, S.P. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)Social class and ethnicity are important risk factors for small-for-gestational-age and preterm delivery in many countries. This study was performed to assess whether this is also the case in the Netherlands, a country with a high level of social security, relatively small income differences and easy access to medical care for all its...article 1994
- document
-
van Ree, J.H. (author), van den Broek, W.J.A.A. (author), Dahlmans, V.E.H. (author), Groot, P.H.E. (author), Vidgeon-Hart, M. (author), Frants, R.R. (author), Wieringa, B. (author), Havekes, L.M. (author), Hofker, M.H. (author), TNO Preventie en Gezondheid (author)Apolipoprotein (apo) E is a ligand for the receptor-mediated uptake of lipoprotein remnant particles. Complete absence of apo E in humans leads to a severe form of type III hyperlipoproteinemia. We have used targeted inactivation in murine embryonic stem cells, as also described by others, to specifically study the effects of heterozygous Apoe...article 1994
- document
- TNO Preventie en Gezondheid (author), Zaal, K. (author) report 1994
- document
-
Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author), Houtman, I.L.D. (author), Bongers, P.M. (author), Smulders, P.G.W. (author), Kompier, M.A.J. (author)Objectives - This paper examines the relationship between work stressors and the following health indicators: psychosomatic complaints, health behavior, and musculoskeletal problems. Methods - Secondary analyses were performed on data from the National Work and Living Condition Survey, which provides a representative sample of the working...article 1994
- document
-
TNO Technische Menskunde (author), Korteling, J.E. (author)In our modern society, complex technological systems typically require people to perform several tasks in a limited period of time. In order to be able to optimize such technological systems, the present thesis aims at explicating some difficulties with regard to the fundamentals of multiple-task performance theory - especially in relation to...doctoral thesis 1994
- document
-
Gaubius Instituut TNO (author), van der Mooren, M.J. (author), Gevers Leuven, J.A. (author), Rolland, R. (author)Objective: To study the possible changes in serum lipids and lipoproteins during hormone replacement therapy with special emphasis on the possible effects brought about by the progestogen. Design: Open-label randomized prospective comparative study. Setting: Gynecological outpatient department of a university hospital. Patients: Thirty-three...article 1994
- document
-
TNO Preventie en Gezondheid (author), Verkerk, P.H. (author), van Spronsen, F.J. (author), van Houten, M. (author), Smit, G.P. (author), Sengers, R.C. (author)We studied the relationship between plasma phenylalanine level at first diagnostic visit, country of origin of the mother, birth cohort, child clinic, sex, and social class on the one hand and mean plasma phenylalanine levels in the first five years of life on the other hand in patients with phenylketonuria (PKU) who were treated early. The...article 1994