Searched for: subject:"adolescent"
(1 - 10 of 10)
document
Draisma, H.H.M. (author), Reijmers, T.H. (author), Bobeldijk - Pastorova, I. (author), Meulman, J.J. (author), van Estourgie - Burk, G.F. (author), Bartels, M. (author), Ramaker, R. (author), van der Greef, J. (author), Boomsma, D.I. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
Differences in genetic background and/or environmental exposure among individuals are expected to give rise to differences in measurable characteristics, or phenotypes. Consequently, genetic resemblance and similarities in environment should manifest as similarities in phenotypes. The metabolome reflects many of the system properties, and is...
article 2008
document
Beekman, M. (author), Posthuma, D. (author), Heijmans, B.T. (author), Lakenberg, N. (author), Suchiman, H.E.D. (author), Snieder, H. (author), de Knijff, P. (author), Frants, R.R. (author), van Ommen, G.J.B. (author), Kluft, C. (author), Vogler, G.P. (author), Slagboom, P.E. (author), Boomsma, D.I. (author)
Combined association and linkage analysis is a powerful tool for pinpointing functional quantitative traits (QTLs) responsible for regions of significant linkage identified in genome-wide scans. We applied this technique to apoE plasma levels and the APOEε2/ε3/ε4 polymorphism in two Dutch twin cohorts of different age ranges. Across chromosome...
article 2004
document
van Dommelen, P. (author), de Gunst, M.C.M. (author), van der Vaart, A.W. (author), Boomsma, D.I. (author)
Longitudinal height and weight data from 4649 Dutch twin pairs between birth and 2.5 years of age were analyzed. The data were first summarized into parameters of a polynomial of degree 4 by a mixed-effects procedure. Next, the variation and covariation in the parameters of the growth curve (size at one year of age, growth velocity, deceleration...
article 2004
document
Beekman, M. (author), Heijmans, B.T. (author), Martin, N.G. (author), Whitfield, J.B. (author), Pedersen, N.L. (author), de Faire, U. (author), Snieder, H. (author), Lakenberg, N. (author), Suchiman, H.E.D. (author), de Knijff, P. (author), Frants, R.R. (author), van Ommen, G.J.B. (author), Kluft, C. (author), Vogler, G.P. (author), Boomsma, D.I. (author), Slagboom, P.E. (author)
The genetic basis of cardiovascular disease (CVD) with its complex etiology is still largely elusive. Plasma levels of lipids and apolipoproteins are among the major quantitative risk factors for CVD and are well-established intermediate traits that may be more accessible to genetic dissection than clinical CVD end points. Chromosome 19 harbors...
article 2003
document
Beekman, M. (author), Heijmans, B.T. (author), Martin, N.G. (author), Whitfield, J.B. (author), Pedersen, N.L. (author), de Faire, U. (author), Snieder, H. (author), Lakenberg, N. (author), de Knijff, P. (author), Frants, R.R. (author), van Ommen, G.J.B. (author), Kluft, C. (author), Vogler, G.P. (author), Slagboom, P.E. (author), Boomsma, D.I. (author)
Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a...
article 2003
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Vogler, G.P. (author), McClearn, G.E. (author), Snieder, H. (author), Boomsma, D.I. (author), Palmer, R. (author), de Knijff, P. (author), Slagboom, P.E. (author), TNO Preventie en Gezondheid (author)
This is the second in a series of three articles addressing the intersection of interests in behavioral genetics and behavioral medicine. In this article, we use risk factors for cardiovascular disease as a prototypical trait for which behavioral genetic approaches provide powerful tools for understanding how risk factors, behavior, and health...
article 1997
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Boomsma, D.I. (author), Kempen, H.J.M. (author), Gevers Leuven, J.A. (author), Havekes, L. (author), de Knijff, P. (author), Frants, R.R. (author), TNO Preventie en Gezondheid (author)
In a sample of Dutch families consisting of parents aged 35-65 years and their twin offspring aged 14-21 years, a significant difference between generations was observed in phenotypic variances and in genetic heritabilities for plasma levels of total cholesterol, triglycerides, high density lipoprotein (HDL) and low density lipoprotein (LDL)...
article 1996
document
Hennis, B.C. (author), Boomsma, D.I. (author), Fijnvandraat, K. (author), Gevers Leuven, J.A. (author), Peters, M. (author), Kluft, C. (author), Gaubius Instituut TNO (author)
Plasma levels of histidine-rich glycoprotein (HRG) were investigated in three groups of women receiving a different dose of estrogens. First, the effect of low-dose estrogen was studied in a group of 83 postmenopausal women who were treated with 0.625 mg conjugated estrogens (CE). No significant change from baseline levels was found at the end...
article 1995
document
Meulenbelt, I. (author), Droog, S. (author), Trommelen, G.J.M. (author), Boomsma, D.I. (author), Slagboom, P.E. (author), TNO Preventie en Gezondheid (author)
article 1995
document
Slagboom, P.E. (author), Droog, S. (author), Boomsma, D.I. (author), TNO Preventie en Gezondheid (author)
Reduction of telomere length has been postulated to be a causal factor in cellular aging. Human telomeres terminate in tandemly arranged repeat arrays consisting of the (TTAGGG) motif. The length of these arrays in cells from human mitotic tissues is inversely related to the age of the donor, indicating telomere reduction with age. In addition...
article 1994
Searched for: subject:"adolescent"
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