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Sijbrands, E.J.G. (author), Hoffer, M.J.V. (author), Meinders, A.E. (author), Havekes, L.M. (author), Frants, R.R. (author), Smelt, A.H.M. (author), de Knijff, P. (author), Gaubius instituut TNO (author)
More than 90% of patients with type III hyperlipoproteinemia are homozygous carriers of the apolipoprotein (apo) E*2 allele. The great majority of these apoE2(Arg158→Cys) homozygotes in the general population, however, are normolipidemic. Apparently, expression of the hyperlipidemic state requires additional genetic and/or environmental factors,...
article 1999
Sijbrands, E.J.G. (author), Lombardi, M.P. (author), Westendorp, R.G.J. (author), Gevers Leuven, J.A. (author), Meinders, A.E. (author), van der Laarse, A. (author), Frants, R.R. (author), Havekes, L.M. (author), Smelt, A.H.M. (author), Gaubius Instituut TNO (author)
In patients heterozygous for familial hypercholesterolemia, the low- density lipoprotein (LDL) cholesterol lowering effect of β-hydroxy-β- methylglutaryl coenzyme A reductase inhibitors may depend on the nature of the mutation in the LDL receptor gene. To test this hypothesis, we compared the response to simvastatin, 20 mg daily for 9 weeks,...
article 1998