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Klous, L. (author), van Diemen, F. (author), Ruijs, S. (author), Gerrett, N. (author), Daanen, H. (author), de Weerd, M. (author), Veenstra, B. (author), Levels, K. (author)
Purpose: Three feasible cooling methods for treatment of hyperthermic individuals in the military, that differed considerably in water volume needed (none to ~80 L), were evaluated. Methods: Ten male soldiers were cooled following exercise-induced hyperthermia (rectal temperature (Tre) ∼39.5 °C) using ventilation by fanning (1.7 m s−1),...
article 2022
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Hussein, A. (author), Krom, A.H.M. (author), Dey, P. (author), Sunnardianto, G.K. (author), Moultos, O.A. (author), Walters, C.L. (author)
article 2021
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Wambaugh, J.F. (author), Hughes, M.F. (author), Ring, C.L. (author), MacMillan, D.K. (author), Ford, J. (author), Fennell, T.R. (author), Black, S.R. (author), Snyder, R.W. (author), Sipes, N.S. (author), Wetmore, B.A. (author), Westerhout, J. (author), Setzer, R.W. (author), Pearce, R.G. (author), Simmons, J.E. (author), Thomas, R.S. (author)
Prioritizing the risk posed by thousands of chemicals potentially present in the environment requires exposure, toxicity, and toxicokinetic (TK) data, which are often unavailable. Relatively high throughput, in vitro TK (HTTK) assays and in vitro-to-in vivo extrapolation (IVIVE) methods have been developed to predict TK, but most of the in vivo...
article 2018
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Zanoletti, M. (author), Marti, A. (author), Marengo, M. (author), Iametti, S. (author), Pagani, M.A. (author), Renzetti, S. (author)
A molecular and material science approach is used to describe the influence of coarse and fine buckwheat bran on wheat dough properties and bread textural quality. Focus is given on (i) gluten solvation and structural arrangements in presence of bran as studied by front-face fluorescence; (ii) thermo-mechanical behavior of dough during heating...
article 2017
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Schultze-Jena, A. (author), Boon, M.A. (author), Bussmann, P.J.T. (author), Janssen, A.E.M. (author), van der Padt, A. (author)
In industrial liquid separation processes chromatography often has a key function in the optimization of yield and purity. For the design of an industrial system, chromatographic processes are generally simulated using mathematical models, tested and optimized at laboratory level, and then scaled up to pilot and subsequently industrial scale. To...
article 2017
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Sharma, M.K. (author), Wieringa, F.P. (author), Frijns, A.J.H. (author), Kooman, J.P. (author)
Introduction: End-stage renal disease (ESRD) patients depend on dialysis for removal of toxic waste products, fluid overload relief and maintenance of electrolyte balance. Dialysis prolongs millions of lives. To some extent, ESRD has become a manageable disease with a steadily growing dialysis population of increasing average age and associated...
article 2016
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Cnubben, N.H.P. (author), Tel, S.L. (author), Hemmes, M.A. (author), Langenkamp-Brand, A. (author), Grossouw, D. (author), Jansen, H.T. (author), de Bie, B.T.H.J. (author)
Background: Worldwide obesity has nearly doubled since 1980 and is a leading risk for global deaths, profoundly affecting morbidity, mortality, health-care costs, and professional and personal quality of life. Treatment of obesity and its consequences include lifestyle intervention, pharmacotherapy, and bariatric surgery. Polyglucosamines have...
article 2016
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Schmidt, R.D.O. (author), Sadre, R. (author), Sperotto, A. (author), van den Berg, H. (author), Pras, A. (author)
Link dimensioning is used by network operators to properly provision the capacity of their network links. Proposed methods for link dimensioning often require statistics, such as traffic variance, that need to be calculated from packet-level measurements. In practice, due to increasing traffic volume, operators deploy packet sampling techniques...
article 2015
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Inui, T. (author), Mandamparambil, R. (author), Araki, T. (author), Abbel, R.J. (author), Koga, H. (author), Nogi, M. (author), Suganuma, K. (author)
Non-contact printing techniques are receiving increasing interest in the field of printed electronics, because they can be used to pattern various inks on arbitrary substrates without applying mechanical pressure or damaging pre-patterned components. The ink-jet process is frequently used for non-contact printing of various conductive inks....
article 2015
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Garner, C.R. (author), Park, K.B. (author), French, N.S. (author), Earnshaw, C. (author), Schipani, A. (author), Selby, A.M. (author), Byrne, L. (author), Siner, S. (author), Crawley, F.P. (author), Vaes, W.H.J. (author), van Duijn, E. (author), de ligt, R. (author), Varendi, H. (author), Lass, J. (author), Grynkiewicz, G. (author), Maruszak, W. (author), Turner, M.A. (author)
Aims The aims of the study were to compare [14C]-paracetamol ([14C]-PARA) paediatric pharmacokinetics (PK) after administration mixed in a therapeutic dose or an isolated microdose and to develop further and validate accelerator mass spectrometry (AMS) bioanalysis in the 0-2 year old age group. Methods [14C]-PARA concentrations in 10-15 μl...
article 2015
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Tan, E. (author), Boessen, R. (author), Fishwick, D. (author), Klein Entink, R. (author), Meijster, T. (author), Pronk, A. (author), van Duuren-Stuurman, B. (author), Warren, N. (author)
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease that is thought to affect over one million people in Great Britain. The main factor contributing to the development of COPD is tobacco smoke. This paper presents a microsimulation model for the development of COPD, incorporating population dynamics and trends in smoking. The...
article 2015
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Peters, E. (author), Egberts, P.J.P. (author), Loeve, D. (author), Hofstee, C. (author)
Geological storage of CO2 in large, saline aquifers needs to be monitored for safety purposes. In particular the observation of the pressure behavior of a storage site is relevant for the indication of CO2 leakage. However, interpretation of observed pressure is not straightforward in these systems, due to the large number of natural processes...
article 2015
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ter Heege, J.H. (author), Zijp, M.H.A.A. (author), de Bruin, G. (author), ten Veen, J.H. (author)
Uncertainties in upfront predictions of hydraulic fracturing and gas production of underexplored shale gas targets are important as often large potential resources are deduced based on limited available data. In this paper, uncertainties are quantified by using normal distributions of different input parameters in wellbased models for hydraulic...
conference paper 2014
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Eeftens, M. (author), Hoek, G. (author), Gruzieva, O. (author), Mölter, A. (author), Agius, R. (author), Beelen, R. (author), Brunekreef, B. (author), Custovic, A. (author), Cyrys, J. (author), Fuertes, E. (author), Heinrich, J. (author), Hoffmann, B. (author), De Hoogh, K. (author), Jedynska, A. (author), Keuken, M. (author), Klümper, C. (author), Kooter, I. (author), Krämer, U. (author), Korek, M. (author), Koppelman, G.H. (author), Kuhlbusch, T.A.J. (author), Simpson, A. (author), Smit, H.A. (author), Tsai, M.Y. (author), Wang, M. (author), Wolf, K. (author), Pershagen, G. (author), Gehring, U. (author)
BACKGROUND: Negative effects of long-term exposure to particulate matter (PM) on lung function have been shown repeatedly. Spatial differences in the composition and toxicity of PM may explain differences in observed effect sizes between studies. METHODS: We conducted a multicenter study in 5 European birth cohorts - BAMSE (Sweden), GINIplus and...
article 2014
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Jin, X. (author), van der Sman, R.G.M. (author), van Maanen, J.F.C. (author), van Deventer, H.C. (author), van Straten, G. (author), Boom, R.M. (author), van Boxtel, A.J.B. (author)
In this work, the Flory Huggins Free Volume theory is used to interpret the sorption isotherms of broccoli from its composition and using physical properties of the components. This theory considers the mixing properties of water, biopolymers and solutes and has the potential to describe the sorption isotherms for varying product moisture...
article 2014
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Louwe, M.C. (author), Karper, J.C. (author), de Vries, M.R. (author), Nossent, A.Y. (author), Bastiaansen, A.J.N.M. (author), van der Hoorn, J.W.A. (author), Willems Van Dijk, K. (author), Rensen, P.C.N. (author), Steendijk, P. (author), Smit, J.W.A. (author), Quax, P.H.A. (author)
Background Toll-like receptor-4 (TLR4), a receptor of the innate immune system, is suggested to have detrimental effects on cardiac function after myocardial infarction (MI). RP105 (CD180) is a TLR4 homolog lacking the intracellular signaling domain that competitively inhibits TLR4-signaling. Thus, we hypothesized that RP105 deficiency, by...
article 2014
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Bakker, L.E.H. (author), Boon, M.R. (author), van der Linden, R.A.D. (author), Arias-Bouda, L.P. (author), van Klinken, J.B. (author), Smit, F. (author), Verberne, H.J. (author), Jukema, J.W. (author), Tamsma, J.T. (author), Havekes, L.M. (author), van Marken Lichtenbelt, W.D. (author), Jazet, I.M. (author), Rensen, P.C.N. (author)
Background: Individuals of south Asian origin have a very high risk of developing type 2 diabetes compared with white Caucasians. We aimed to assess volume and activity of brown adipose tissue (BAT), which is thought to have a role in energy metabolism by combusting fatty acids and glucose to produce heat and might contribute to the difference...
article 2014
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Schiavon, G. (author), Ruggiero, A. (author), Bekers, D.J. (author), Barry, P.A. (author), Sleijfer, S. (author), Kloth, J. (author), Krestin, G.P. (author), Schöffski, P. (author), Verweij, J. (author), Mathijssen, R.H.J. (author)
Purpose: Tumour response assessment to therapy is crucial in oncology. We analysed the morphology of liver metastases (LM) in gastrointestinal stromal tumour (GIST) patients to determine whether uni-dimensional measurement of lesions by Response Evaluation Criteria in Solid Tumours (RECIST), accurately reflects lesion volume. Materials and...
article 2014
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Louwe, M.C. (author), Karper, J.C. (author), de Vries, M.R. (author), Bastiaansen, A.J.N.M. (author), van der Hoorn, J.W.A. (author), Willems Van Dijk, K. (author), Rensen, P.C.N. (author), Steendijk, P. (author), Smit, J.W.A. (author), Quax, P.H.A. (author)
Purpose: Toll-like receptor-4 (TLR4), a receptor of the innate immune system, is suggested to have detrimental effects on cardiac function after myocardial infarction (MI). RP105 (CD180) is a TLR4 homolog lacking the intracellular signalling domain that competitively inhibits TLR4-signalling. Thus, we hypothesized that RP105 deficiency, by...
article 2014
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James, N.K. (author), van den Ende, D.A. (author), Lafont, U. (author), van der Zwaag, S. (author), Groen, W.A. (author)
Structured lead zirconium titanate (PZT)-epoxy composites are prepared by dielectrophoresis. The piezoelectric and dielectric properties of the composites as a function of PZT volume fraction are investigated and compared with the corresponding unstructured composites. The effect of poling voltage on piezoelectric properties of the composites is...
article 2013
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