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van Boxtel, E.L. (author), van Koningsveld, G.A. (author), Koppelman, S.J. (author), van den Broek, L.A.M. (author), Voragen, A.G.J. (author), Gruppen, H. (author), TNO Kwaliteit van Leven (author)A new, fast, large-scale purification method for Ber e 1, the major allergen from Brazil nuts, using expanded bed adsorption (EBA) chromatography, is presented. Using EBA, crude extracts can be applied to a fluidized column, which allows the unhindered passage of particulate impurities, thereby avoiding time-consuming centrifugation or...article 2006
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Moreno, J.F. (author), Asner, G.P. (author), Bach, H. (author), Belenguer, T. (author), Bell, A. (author), Buschmann, C. (author), Calera, A. (author), Calpe, J. (author), Campbell, P. (author), Cecchi, G. (author), Colombo, R. (author), Corp, L.A. (author), Court, A.J. (author), Cutter, M.A. (author), Disney, M. (author), Dudelzak, A. (author), D'Urso, G. (author), Fernandes, R. (author), Flexas, J. (author), Gege, P. (author), Gielen, B. (author), Gitelson, A. (author), Gloor, E.U. (author), Gower, J. (author), Green, R.O. (author), Hill, J. (author), Jacquemoud, S. (author), Jia, L. (author), Kneubühler, M. (author), Laurila, T. (author), Lewis, P. (author), Lobb, D. (author), Magnani, F. (author), Maier, S.W. (author), Marek, M.V. (author), Martinez, A. (author), Martinez-Cobo, P. (author), Mazzinghi, P. (author), Menenti, M. (author), Merton, R. (author), Middleton, E. (author), de Miguel, E. (author), Miller, J. (author), Mohammed, G. (author), Milton, E.J. (author), Morales, F. (author), Moya, I. (author), Nedbal, L. (author), Knorr, W. (author), Ottlé, C. (author), Olioso, A. (author), Pace, S. (author), Palucci, A. (author), Pedros, R. (author), Peltoniemi, J. (author), Peñuelas, J. (author), Plaza, A. (author), Polcher, J. (author), Rascher, U. (author), Reuter, R. (author), Rosema, A. (author), Roujean, J.L. (author), Saito, Y. (author), Saugier, B. (author), Schaepman, M. (author), Serrano, J.B. (author), Settle, J.J. (author), Sierra, M. (author), Sobrino, J. (author), Stoll, M.P. (author), Bob Su, Z. (author), Tobehn, C. (author), Tremblay, N. (author), Valcke, R. (author), Verhoef, W. (author), Veroustraete, F. (author), Verstraete, M. (author), Zarco-Tejada, P. (author), TNO Industrie en Techniek (author)The FLuorescence EXplorer (FLEX) mission proposes to launch a satellite for the global monitoring of steady-state chlorophyll fluorescence in terrestrial vegetation. Fluorescence is a sensitive probe of photosynthetic function in both healthy and physiologically perturbed vegetation, and a powerful non-invasive tool to track the status,...conference paper 2006
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van Hoof, T.B. (author), Bunnik, F.P.M. (author), Waucomont, J.G.M. (author), Kürschner, W.M. (author), Visscher, H. (author)Well-dated pollen assemblages from an organic-rich infill of an oxbow lake of the river Roer (southeastern Netherlands) provide a high-resolution reconstruction of regional vegetation development and land-use for the period between AD 1000 and 1500. Regional effects of the mid-14th century plague pandemic known as the Black Death are reflected...article 2006
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Balder, H.F. (author), de Vogel, J. (author), Jansen, M.C.J.F. (author), Weijenberg, M.P. (author), van den Brandt, P.A. (author), Westenbrink, S. (author), van der Meer, R.D. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven (author)Background: The evidence for red meat as a determinant of colorectal cancer remains equivocal, which might be explained by differences in heme content. Heme is the prooxidant, iron-containing porphyrin pigment of meat and its content depends on the type of meat. Chlorophyll from green vegetables might modify this association. Methods: The...article 2006
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Hamer, R.J. (author), TNO Kwaliteit van Leven (author)Coeliac Disease has to be considered a main food related affliction, with life long consequences for the people having the disease. Coeliac Disease patients suffer from adverse effects that can be related to specific gluten peptide sequences that trigger a sequence of immune related reactions leading to damage of the intestine and related...article 2005
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Janssen, E.G.O.N. (author), Tse, T.C. (author), Mas, J.L. (author), Elvira, J. (author), Hovland, S. (author), TNO Bouw en Ondergrond (author)This paper describes a design proposal for adapting the OGEGU Food Production Unit (FPU) to the surface of Mars in order to produce up to 40% of the diet for a six-member crew by growing a pre-defined set of vegetable food species. The external structure, lighting system and plant support system are assessed using ESM analysis. The study shows...conference paper 2005
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Männistö, S. (author), Dixon, L.B. (author), Balder, H.F. (author), Virtanen, M.J. (author), Krogh, V. (author), Khani, B.R. (author), Berrino, F. (author), van den Brandt, P.A. (author), Hartman, A.M. (author), Pietinen, P. (author), Tan, F. (author), Wolk, A. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven TNO Voeding (author)Objective: Only a few consistent findings on individual foods or nutrients that influence breast cancer risk have emerged thus far. Since people do not consume individual foods but certain combinations of them, the analysis of dietary patterns may offer an additional aspect for assessing associations between diet and diseases such as breast...article 2005
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Mas, J.L. (author), Vanrobaeys, X. (author), Hagenbeek, D. (author), Chaerle, L. (author), van der Straeten, D. (author), Kassel, R. (author), Janssen, E.G.O.N. (author), Hovland, S. (author), TNO Bouw en Ondergrond (author)Interest on food production systems based on the cultivation of vegetables for future planetary exploration missions is increasing as these units can help overcoming difficult and costly re-supply logistics. In addition to producing edible biomass by growing vegetable species, these systems can be used in closed loop configuration with bio...conference paper 2005
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Wark, P.A. (author), Weijenberg, M.P. (author), van 't Veer, P. (author), van Wijhe, G. (author), Luchtenborg, M. (author), van Muijen, G.N.P. (author), de Goeij, A.F.P.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Background: Clinical and pathologic differences exist between colon carcinomas deficient and proficient in the mismatch repair protein hMLH1. Animal and in vitro studies suggest that fruits, vegetables, folate, and antioxidants are associated with colonic expression of mismatch repair genes. Methods: Associations between consumption of fruits...article 2005
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Balder, H.F. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)The objective of this article was to study the association between dietary patterns and lung cancer incidence in the Netherlands Cohort Study on Diet and Cancer. The baseline measurement of this prospective case cohort study that was completed by 58,279 men in 1986 included a self-administered questionnaire on dietary intake, smoking habits, and...article 2005
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Koushik, A. (author), Hunter, D.J. (author), Spiegelman, D. (author), Anderson, K.E. (author), Arslan, A.A. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Buring, J.E. (author), Cerhan, J.R. (author), Colditz, G.A. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Genkinger, J.M. (author), Goldbohm, R.A. (author), Hankinson, S.E. (author), Koenig, K.L. (author), Larsson, S.C. (author), Leitzmann, M. (author), McCullough, M.L. (author), Miller, A.B. (author), Patel, A. (author), Rohan, T.E. (author), Schatzkin, A. (author), Smit, E. (author), Willett, W.C. (author), Wolk, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)Because fruits and vegetables are rich in bioactive compounds with potential cancer-preventive actions, increased consumption may reduce the risk of ovarian cancer. Evidence on the association between fruit and vegetable intake and ovarian cancer risk has not been consistent. We analyzed and pooled the primary data from 12 prospective studies in...article 2005
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Mommers, M. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)BACKGROUND. To the authors' knowledge, only a few prospective studies to date have investigated the correlation between vegetable and fruit consumption and the risk of ovarian carcinoma and their results have been inconclusive. METHODS. Vegetable and fruit intake was assessed in relation to ovarian carcinoma, among 62,573 postmenopausal women...article 2005
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van Dijk, B.A.C. (author), Schouten, L.J. (author), Kiemeney, L.A.L.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Vegetable and fruit consumption is generally inversely associated with various cancer types, including renal cell carcinoma (RCC). The Netherlands cohort study on diet and cancer (NLCS) consists of 120,852 men and women, aged 55-69 years, who filled out a self-administered questionnaire that includes ISO-item food-frequency questions and...article 2005
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TNO Kwaliteit van Leven (author), Knippels, L.M.J. (author), Penninks, A.H. (author)The potential allergenicity of newly introduced proteins in genetically engineered foods has become an important safety evaluation issue. However, to evaluate the potential allergenicity and the potency of new proteins in our food, there are still no widely accepted and reliable test systems. The best-known allergy assessment proposal for foods...article 2005
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Minekus, M. (author), Jelier, M. (author), Xiao, J.-Z. (author), Kondo, S. (author), Iwatsuki, K. (author), Kokubo, S. (author), Bos, M. (author), Dunnewind, B. (author), Havenaar, R. (author), TNO Kwaliteit van Leven (author)The Addition of a compound that lowers the intestinal uptake of fat and cholesterol might be an interesting strategy to reduce the risk of vascular disease. Partially hydrolyzed guar gum (PHGG) has been shown to have this effect in healthy volunteers after intake of a yogurt drink with 3 to 6% PHGG. In the present study a yogurt drink with 3%...article 2005
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Maraschin, S.D.F. (author), Gaussand, G. (author), Pulido, A. (author), Olmedilla, A. (author), Lamers, G.E.M. (author), Korthout, H. (author), Spaink, H.P. (author), Wang, M. (author)Androgenesis represents one of the most fascinating examples of cell differentiation in plants. In barley, the conversion of stressed uninucleate microspores into embryo-like structures is highly efficient. One of the bottlenecks in this process is the successful release of embryo-like structures out of the exine wall of microspores. In the...article 2005
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Dagnelie, P.C. (author), Schuurman, A.G. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding (author)We reviewed 37 prospective cohort and four intervention studies on potential dietary risk factors for prostate cancer, published between 1966 and September 2003. Some studies were limited by small size, crude measurement of dietary exposure and limited control for confounders. Intervention and prospective cohort studies support a protective role...article 2004
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O'Kane, F.E. (author), Happe, R.P. (author), Vereijken, J.M. (author), Gruppen, H. (author), van Boekel, M.A.J.S. (author), TNO Voeding (author)Gel network formation of pea legumin (8.4% on a protein basis, pH 7.6) was monitored via dynamic rheological measurements. Gelation was performed in the absence and presence of the thiol-blocking reagent N-ethylmaleimide, at different rates of heating and cooling. Overall, it was shown that pea legumin gel formation was not effected by changes...article 2004
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Jansen, M.C.J.F. (author), van Kappel, A.L. (author), Ocké, M.C. (author), van 't Veer, P. (author), Boshuizen, H.C. (author), Riboli, E. (author), Bueno-de-Mesquita, H.B. (author), TNO Voeding (author)Objective: Fruit and vegetable intake is inversely associated with cancer risk in many epidemiological studies. Accurate assessment of consumption of these foods is difficult, and biomarkers of intake would overcome several drawbacks of currently used dietary assessment methods. Therefore, we investigated the relation between plasma carotenoids...article 2004
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Bemelmans, W.J.E. (author), Broer, J. (author), Hulshof, K.F.A.M. (author), Siero, F.W. (author), May, J.F. (author), Meyboom-de Jong, B. (author), TNO Voeding (author)Background: Treatment of persons at high risk for coronary heart disease (CHD) should include nutritional counselling, but little is known about the effects of different types of education. Methods: In a quasi-experimental study design the effects of a nutritional education programme (1st year: three group sessions by a dietitian; 2nd year: one...article 2004