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TNO Kwaliteit van Leven (author), Altorf, W. (author), van der Kuil, W.A. (author), Engberink, M.F. (author), Brink, E.J. (author), van Baak, M.A. (author), Bakker, S.J.L. (author), Navis, G. (author), van't Veer, P. (author), Geleijnse, J.M. (author)Background: Elevated blood pressure (BP), which is a major risk factor for cardiovascular disease, is highly prevalent worldwide. Recently, interest has grown in the role of dietary protein in human BP. We performed a systematic review of all published scientific literature on dietary protein, including protein from various sources, in relation...article 2010
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Gubbels, J.S. (author), Kremers, S.P.J. (author), Stafleu, A. (author), Dagnelie, P.C. (author), de Vries, S.I. (author), de Vries, N.K. (author), Thijs, C. (author), TNO Kwaliteit van Leven (author)Objective: To examine clustering of energy balance-related behaviors (EBRBs) in young children. This is crucial because lifestyle habits are formed at an early age and track in later life. This study is the first to examine EBRB clustering in children as young as 2 years. Study design: Cross-sectional data originated from the Child, Parent and...article 2009
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Gubbels, J.S. (author), Kremers, S.P.J. (author), Stafleu, A. (author), Dagnelie, P.C. (author), Goldbohm, R.A. (author), de Vries, N.K. (author), Thijs, C. (author), TNO Kwaliteit van Leven (author)This study examined the relationship between diet-related parenting practices, parental characteristics, child characteristics, and 2-year-old child's dietary intake. Cross-sectional data (N = 2578) originated from the KOALA Birth Cohort Study. Principal component analyses revealed two restrictive parenting practice clusters: a cluster...article 2009
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van Boxtel, E.L. (author), van den Broek, L.A.M. (author), Koppelman, S.J. (author), Gruppen, H. (author), TNO Kwaliteit van Leven (author)Legumin proteins Ara h 3 from peanuts and glycinin from soybeans are increasingly described as important allergens. The stability of an allergen's IgE binding capacity towards heating and digestion is considered an important characteristic for food allergens. We investigated the effects of heating and digestion on the IgE binding of Ara h 3 and...article 2008
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Beumer, V. (author), van Wirdum, G. (author), Beltman, B. (author), Griffioen, J. (author), Grootjans, A.P. (author), Verhoeven, J.T.A. (author), TNO Bouw en Ondergrond (author)Dutch water policy aims for more frequent, controlled flooding of river valley floodplains to avoid unwanted flooding elsewhere; in anticipation of increased flooding risks resulting from climate changes. Controlled flooding usually takes place in winter in parts of the valleys which had not been subject to flooding in the last decades. It may...article 2008
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van Dokkum, W. (author), Frølich, W. (author), Saltmarsh, M. (author), Gee, J. (author), TNO Kwaliteit van Leven (author)COST (European Cooperation in the field of Scientific and Technical Research) Action 926 is a networking partnership funded by the European Union through the European Science Foundation. Scientists involved have evaluated whether or not the new 'omic' technologies can offer a means of obtaining the scientific evidence to underpin the established...article 2008
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van Boxtel, E.L. (author), Koppelman, S.J. (author), van den Broek, L.A.M. (author), Gruppen, H. (author), TNO Kwaliteit van Leven (author), KvL (author)This study was aimed at the determination of the pepsin-susceptible and pepsin-resistant epitopes in native and heat-treated Ara h 1, a major allergen from peanuts. Both the oligomeric structure and the trimeric structure of the allergen were investigated. Under the in vitro conditions applied, oligomeric Ara h 1, either unheated or preheated,...article 2008
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Wang, Y. (author), Xiao, Y. (author), Zhang, Y. (author), Chai, C. (author), Wei, G. (author), Wei, X. (author), Xu, H. (author), Wang, M. (author), Ouwerkerk, P.B.F. (author), Zhu, Z. (author), TNO Kwaliteit van Leven (author)Monosaccharides transporters play important roles in assimilate supply for sink tissue development. In this study, a new monosaccharide transporter gene OsMST6 was identified from rice (Oryza sativa L.). The predicted OsMST6 protein shows typical features of sugar transporters and shares 79.6% identity with the rice monosaccharide transporter...article 2008
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Preller, L. (author), Balder, H.F. (author), Tielemans, E. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven (author)Objectives: To assess male lung cancer risks for industrial sectors in the Netherlands and to estimate the proportion of lung cancer attributed to working in specific industrial sectors. Methods: Associations were studied among men aged 55-69 years (n = 58 279) from the prospective Netherlands Cohort Study. 1920 incident lung cancer cases were...article 2008
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TNO Kwaliteit van Leven (author), Pasman, W.J. (author), Heimerikx, J. (author), Rubingh, C.M. (author), van den Berg, R. (author), O'Shea, M. (author), Gambelli, L. (author), Hendriks, H.F.J. (author), Einerhand, A.W.C. (author), Scott, C. (author), Keizer, H.G. (author), Mennen, L.I. (author)Appetite suppressants may be one strategy in the fight against obesity. This study evaluated whether Korean pine nut free fatty acids (FFA) and triglycerides (TG) work as an appetite suppressant. Korean pine nut FFA were evaluated in STC-1 cell culture for their ability to increase cholecystokinin (CCK-8) secretion vs. several other dietary...article 2008
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Wang, Y. (author), Xu, H. (author), Wei, X. (author), Chai, C. (author), Xiao, Y. (author), Zhang, Y. (author), Chen, B. (author), Xiao, G. (author), Ouwerkerk, P.B.F. (author), Wang, M. (author), Zhu, Z. (author), TNO Kwaliteit van Leven (author)Monosaccharide transporters mediate the membrane transport of a variable range of monosaccharides, which plays a crucial role in sugar distribution throughout the plant. To investigate the significance of monosaccharide transporters for rice (Oryza sativa L.) seed development, cDNA of a new putative monosaccharide transporter gene OsMST4 was...article 2007
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van Boxtel, E.L. (author), van den Broek, L.A.M. (author), Koppelman, S.J. (author), Vincken, J.-P. (author), Gruppen, H. (author), TNO Kwaliteit van Leven (author)Mildly extracted peanut allergen Ara h 1 was previously reported to occur as an oligomeric complex. In this paper we describe how the protein in this oligomeric complex interacts noncovalently with phenolic compounds of the proanthocyanidin type. These interactions are being disrupted during anion exchange chromatography, resulting in the...article 2007
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Heiri, O. (author), Cremer, H. (author), Engels, S. (author), Hoek, W.Z. (author), Peeters, W. (author), Lotter, A.F. (author), TNO Bouw en Ondergrond (author)Lateglacial environments at Hijkermeer, northwest Netherlands, were reconstructed by means of chironomid, diatom and pollen analyses. Diatom assemblages indicate that Hijkermeer was a shallow, oligo- to mesotrophic lake during this period. Pollen assemblages reflect the typical northwest European Lateglacial vegetation development and provide an...article 2007
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Kemna, H.A. (author), Westerhoff, W.E. (author), TNO Bouw en Ondergrond (author)The chronostratigraphical subdivision of the Pliocene and Early Pleistocene as applied in terrestrial deposits of Central and NW-Europe largely relies on the pollen analytical investigations. This subdivision is almost entirely based on the interpretation of quantitative changes of the vegetational cover as recorded by the pollen content of...article 2007
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Koushik, A. (author), Hunter, D.J. (author), Spiegelman, D. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Buring, J.E. (author), Calle, E.E. (author), Cho, E. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Fuchs, C.S. (author), Giovannucci, E.L. (author), Goldbohm, R.A. (author), Harnack, L. (author), Jacobs Jr., D.R. (author), Kato, I. (author), Krogh, V. (author), Larsson, S.C. (author), Leitzmann, M.F. (author), Marshall, J.R. (author), McCullough, M.L. (author), Miller, A.B. (author), Pietinen, P. (author), Rohan, T.E. (author), Schatzkin, A. (author), Sieri, S. (author), Virtanen, M.J. (author), Wolk, A. (author), Zeleniuch-Jacquotte, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)Background Fruit and vegetable intakes have been associated with a reduced risk of colon cancer; however, in more recent studies associations have been less consistent. Statistical power to examine associations by colon site has been limited in previous studies. Methods Fruit and vegetable intakes in relation to colon cancer risk were examined...article 2007
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Beumer, V. (author), van Wirdum, G. (author), Beltman, B. (author), Griffioen, J. (author), Verhoeven, J.T.A. (author), TNO Bouw en Ondergrond (author)Climatic change has great impacts on stream catchments and their ecology. Expectations are that more extreme climate events will result in undesired flooding in stream catchments. In the Netherlands, former floodplains with a history of agricultural use are put into use again as flooding areas for the purpose of water retention. This study...article 2007
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Koppelman, S.J. (author), Vlooswijk, R. (author), Bottger, G. (author), van Duijn, G. (author), van der Schaft, P. (author), Dekker, J. (author), van Bemgen, H. (author), TNO Kwaliteit van Leven (author)An enzyme-linked immunosorbent assay for the detection of mustard protein was developed. The assay is based on a polyclonal antiserum directed against a mixture of mustard proteins raised in rabbits. The assay has a detection limit of 1.5 ppm (milligrams per kilogram) and is suitable for the detection of traces of mustard protein in mustard seed...article 2007
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van den Brandt, P.A. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven (author)Diet has been hypothesized to play a role in the etiology of gastrointestinal cancer for a long time. Initially, strong evidence of such effects was found in retrospective epidemiological studies. Dietary habits, in particular those from the distant past, are difficult to measure, however. Results from recent, prospective and larger studies of...article 2006
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Vermeulen, M. (author), van den Berg, R. (author), Freidig, A.P. (author), van Bladeren, P.J. (author), Vaes, W.H.J. (author), TNO Kwaliteit van Leven (author)A high intake of cruciferous vegetables is associated with a reduced risk of cancer and cardiovascular diseases. This protective effect has been linked to isothiocyanates, enzymatic hydrolysis products of glucosinolates. In this study, the metabolic fate of glucosinolates and isothiocyanates after ingestion of 19 different cruciferous vegetables...article 2006
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van Boxtel, E.L. (author), van Beers, M.M.C. (author), Koppelman, S.J. (author), van den Broek, L.A.M. (author), Gruppen, H. (author), TNO Kwaliteit van Leven (author)Ara h 1, a major peanut allergen, is known as a stable trimeric protein. Nevertheless, upon purification of native Ara h 1 from peanuts using only size exclusion chromatography, the allergen appeared to exist in an oligomeric structure, rather than as a trimeric structure. The oligomeric structure was independent of the salt concentration...article 2006