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Alcohol consumption and type 2 diabetes: Influence of genetic variation in alcohol dehydrogenase

Beulens, J.W.J. (author), Rimm, E.B. (author), Hendriks, H.F.J. (author), Hu, F.B. (author), Manson, J.E. (author), Hunter, D.J. (author), Mukamal, K.J. (author), TNO Kwaliteit van Leven (author)

OBJECTIVE - We sought to investigate whether a polymorphism in the alcohol dehydrogenase 1c (ADH1C) gene modifies the association between alcohol consumption and type 2 diabetes. RESEARCH DESIGN AND METHODS - In nested case-control studies of 640 women with incident diabetes and 1,000 control subjects from the Nurses' Health Study and 383 men...

article 2007

document

Cultured human adult microglia from different donors display stable cytokine, chemokine and growth factor gene profiles but respond differently to a pro-inflammatory stimulus

Meeuwsen, S. (author), Bsibsi, M. (author), Persoon-Deen, C. (author), Ravid, R. (author), van Noort, J.M. (author), TNO Preventie en Gezondheid (author)

Objectives: Brain microglia are highly responsive cells in the central nervous system that exert key functions in host defense as well as in neuroprotection and regeneration. In this study the gene expression profiles for 268 cytokines, chemokines, growth factors and their receptors were examined in cultures of purified human adult microglia,...

article 2005

document

The case for strategic international alliances to harness nutritional genomics for public and personal health

TNO Kwaliteit van Leven (author), Kaput, J. (author), Ordovas, J.M. (author), Ferguson, L. (author), van Ommen, B. (author), Rodriguez, R.L. (author), Allen, L. (author), Ames, B.N. (author), Dawson, K. (author), German, B. (author), Krauss, R. (author), Malyj, W. (author), Archer, M.C. (author), Barnes, S. (author), Bortholomew, A. (author), Birk, R. (author), van Bladeren, P. (author), Bradford, K.J. (author), Brown, K.H. (author), Caetano, R. (author), Castle, D. (author), Chadwick, R. (author), Clarke, S. (author), Clemént, K. (author), Cooney, C.A. (author), Corella, D. (author), da Cruz, I.B.M. (author), Daniel, H. (author), Duster, T. (author), Ebbesson, S.O.E. (author), Elliott, R. (author), Fairweather-Tait, S. (author), Felton, J. (author), Fenech, M. (author), Finley, J.W. (author), Fogg-Johnson, N. (author), Gill-Garrison, R. (author), Gibney, M.J. (author), Gillies, P.J. (author), Gustafsson, J.A. (author), Hartman IV, J.L. (author), He, L. (author), Hwang, J.K. (author), Jais, J.P. (author), Jang, Y. (author), Joost, H. (author), Junien, C. (author), Kanter, M. (author), Kibbe, W.A. (author), Koletzko, B. (author), Korf, B.R. (author), Kornman, K. (author), Krempin, D.W. (author), Langin, D. (author), Lauren, D.R. (author), Lee, J.H. (author), Leveille, G.A. (author), Lin, S.J. (author), Mathers, J. (author), Mayne, M. (author), McNabb, W. (author), Milner, J.A. (author), Morgan, P. (author), Muller, M. (author), Nikolsky, Y. (author), van der Ouderaa, F. (author), Park, T. (author), Pensel, N. (author), Perez-Jimenez, F. (author), Poutanen, K. (author), Roberts, M. (author), Saris, W.H.M. (author), Schuster, G. (author), Shelling, A.N. (author), Simopoulos, A.P. (author), Southon, S. (author), Shyong Tai, E. (author), Towne, B. (author), Trayhurn, P. (author), Uauy, R. (author), Visek, W.J. (author), Warden, C. (author), Weiss, R. (author), Wiencke, J. (author), Winkler, J. (author), Wolff, G.L. (author), Zhao-Wilson, X. (author), Zucker, J.D. (author)

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can...

article 2005

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A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism

TNO Kwaliteit van Leven (author), Verschuur, M. (author), Jong, M.de (author), Felida, L. (author), Maat, M.P.M.de (author), Vos, H.L. (author)

An elevated plasma fibrinogen level is an independent risk factor for cardiovascular disease. Therefore, an understanding of the regulation of fibrinogen expression is important. Inflammation and genetic variation of the fibrinogen beta gene regulate plasma fibrinogen levels, and there are indications that inflammation and genetic variation...

article 2005

document

Exploring Lactobacillus plantarum genome diversity by using microarrays

TNO Kwaliteit van Leven TNO Voeding (author), Molenaar, D. (author), Bringel, F. (author), Schuren, F.H. (author), Vos, W.M.de (author), Siezen, R.J. (author), Kleerebezem, M. (author)

Lactobacillus plantarum is a versatile and flexible species that is encountered in a variety of niches and can utilize a broad range of fermentable carbon sources. To assess if this versatility is linked to a variable gene pool, microarrays containing a subset of small genomic fragments of L. plantarum strain WCFS1 were used to perform stringent...

article 2005

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Interindividual variation in the response by fibrinogen, C-reactive protein and interleukin-6 to yellow fever vaccination

Verschuur, M. (author), van der Beek, M.T. (author), Tak, H.S. (author), Visser, L.G. (author), de Maat, M.P.M. (author), Gaubius Instituut TNO (author)

The acute phase reaction is important in many disease processes. Habitual levels of the acute phase proteins fibrinogen, C-reactive protein (CRP) and interleukin-6 (IL-6) are associated with an increased risk of cardiovascular disease, but the dynamic variation of plasma levels of acute phase proteins may be of importance as well. The aim of...

article 2004

document

Preeclampsia and its interaction with common variants in thrombophilia genes

de Maat, M.P.M. (author), Jansen, M.W.J.C. (author), Hille, E.T.M. (author), Vos, H. (author), Bloemenkamp, K.W.M. (author), Buitendijk, S.E. (author), Helmerhorst, F.M. (author), Wladimiroff, J.W. (author), Bertina, R.M. (author), de Groot, C.J.M. (author), TNO Preventie en Gezondheid (author)

Recently, it has been proposed that abnormalities in coagulation and fibrinolysis contribute to the development of preeclampsia by increasing the thrombotic tendency. This hypothesis was tested in women who have had preeclampsia (cases) compared with matched controls. Polymorphisms in the thrombophilia genes {plasminogen activator inhibitor type...

article 2004

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Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population

Beekman, M. (author), Heijmans, B.T. (author), Martin, N.G. (author), Whitfield, J.B. (author), Pedersen, N.L. (author), de Faire, U. (author), Snieder, H. (author), Lakenberg, N. (author), Suchiman, H.E.D. (author), de Knijff, P. (author), Frants, R.R. (author), van Ommen, G.J.B. (author), Kluft, C. (author), Vogler, G.P. (author), Boomsma, D.I. (author), Slagboom, P.E. (author)

The genetic basis of cardiovascular disease (CVD) with its complex etiology is still largely elusive. Plasma levels of lipids and apolipoproteins are among the major quantitative risk factors for CVD and are well-established intermediate traits that may be more accessible to genetic dissection than clinical CVD end points. Chromosome 19 harbors...

article 2003

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TR3 orphan receptor is expressed in vascular endothelial cells and mediates cell cycle arrest

Arkenbout, E.K. (author), van Bragt, M. (author), Eldering, E. (author), van Bree, C. (author), Grimbergen, J.M. (author), Quax, P.H.A. (author), Pannekoek, H. (author), de Vries, C.J.M. (author), Gaubius Instituut TNO (author)

Objective - Endothelial cells play a pivotal role in vascular homeostasis. In this study, we investigated the function of the nerve growth factor-induced protein-B (NGFI-B) subfamily of nuclear receptors comprising the TR3 orphan receptor (TR3), mitogen-induced nuclear orphan receptor (MINOR), and nuclear orphan receptor of T cells (NOT) in...

article 2003

document

Genetics of C-Reactive Protein: New Possibilities and Complications

Kluft, C. (author), de Maat, M.P.M. (author), Gaubius Instituut TNO (author)

article 2003

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Differences in denaturation of genetic variants of soy glycinin

TNO Voeding (author), Lakemond, C.M.M. (author), de Jongh, H.H.J. (author), Gruppen, H. (author), Voragen, A.G.J. (author)

In heat denaturation studies conducted in the past the genetic variants of glycinin have been considered as a homogeneous group of proteins. In this work the validity of this assumption was tested. It was found by calorimetric studies that glycinin denatures heterogeneously at pH 7.6. When the temperature of isothermal treatment is increased...

article 2002

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Establishing a campylobacter-free pig population through a top-down approach

Weijtens, M.J.B.M. (author), Urlings, H.A.P. (author), van der Plas, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Fattening pigs are often infected with campylobacter. To eliminate campylobacter from the pig population, a top-down approach, involving the breeding and reproduction farms, seems appropriate. In order to investigate the effectiveness of a top-down approach, sows' faeces from the following farms were analysed for the presence of campylobacter:...

article 2000

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ApoE polymorphism accounts for only part of the genetic variation in quantitative ApoE levels

Gaubius Instituut TNO Preventie en Gezondheid (author), Neale, M.C. (author), de Knijff, P. (author), Havekes, L.M. (author), Boomsma, D.I. (author)

ApoE levels and chromosome 19 ApoE polymorphisms were measured in a sample of 156 Dutch families. Each pedigree consisted of parents aged 35-65 years and their twin offspring aged 14-21 years. A significant effect of the chromosome 19 apoE locus on quantitative plasma levels of apolipoprotein E was observed. The ApoE polymorphism explained 16%...

article 2000

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Campylobacter infections in fattening pigs; Excretion pattern and genetic diversity

Weijtens, M.J.B.M. (author), Reinders, R.D. (author), Urlings, H.A.P. (author), van der Plas, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

The excretion of campylobacter by eight individually housed fattening pigs was monitored during 15 weeks. Rectal faeces samples were collected six times from these pigs and twice from their mothers (seven sows). Campylobacter was cultured from these samples on Preston medium. In some pigs, samples positive for campylobacter alternated with...

article 1999

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The role of biotransformation in dietary (anti)carcinogenesis

van Iersel, M.L.P.S. (author), Verhagen, H. (author), van Bladeren, P.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

The fact that dietary compounds influence the susceptibility of human beings to cancer, is widely accepted. One of the possible mechanisms that is responsible for these (anti)carcinogenic effects is that dietary constituents may modulate biotransformation enzymes, thereby affecting the (anti)carcinogenic potential of other compounds. This...

article 1999

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Angiotensin I-converting enzyme and plasminogen activator inhibitor-1 gene variants: Risk of mortality and fatal cardiovascular disease in an elderly population-based cohort

Heijmans, B.T. (author), Westendorp, R.G.J. (author), Knook, D.L. (author), Kluft, C. (author), Slagboom, P.E. (author), Gaubius instituut TNO (author)

OBJECTIVES: We studied the contribution of putative risk genotypes at the angiotensin I-converting enzyme inhibitor (ACE D/D) and plasminogen activator inhibitor-1 (PAI-1 4G/4G) loci to all-cause and cardiovascular mortality in a population-based cohort. BACKGROUND: The ACE D/D and PAI-1 4G/4G genotypes have been consistently associated with...

article 1999

document

Expression and secretion of defined cutinase variants by Aspergillus awamori

van Gemeren, I.A. (author), Beijersbergen, A. (author), van den Hondel, C.A.M.J.J. (author), Verrips, C.T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Several cutinase variants derived by molecular modelling and site- directed mutagenesis of a cutinase gene from Fusarium solani pisi are poorly secreted by Saccharomyces cerevisiae. The majority of these variants are successfully produced by the filamentous fungus Aspergillus awamori. However, the L51S and T179Y mutations caused reductions in...

article 1998

document

Functional involvement of CD44, a family of cell adhesion molecules, in immune responses, tumour progression and haematopoiesis

Günthert, U. (author), Schwärzler, C. (author), Wittig, B. (author), Laman, J. (author), Ruiz, P. (author), Stauder, R. (author), Bloem, A. (author), Smadja-Joffe, F. (author), Zöller, M. (author), Rolink, A. (author), TNO Preventie en Gezondheid (author)

bookPart 1998

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Evaluation of molecular typing techniques to assign genetic diversity among Saccharomyces cerevisiae strains

Baleiras Couto, M.M. (author), Eijsma, B. (author), Hofstra, H. (author), Huis in 't Veld, J.H.J. (author), van der Vossen, J.M.B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Discrimination of strains within the species Saccharomyces cerevisiae was demonstrated by the use of four different techniques to type 15 strains isolated from spoiled wine and beer. Random amplified polymorphic DNA with specific oligonucleotides and PCR fingerprinting with the microsatellite oligonucleotide primers (GAC)5 and (GTG)5 enabled...

article 1996

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Genetic analysis of sex and generation differences in plasma lipid, lipoprotein, and apolipoprotein levels in adolescent twins and their parents

Boomsma, D.I. (author), Kempen, H.J.M. (author), Gevers Leuven, J.A. (author), Havekes, L. (author), de Knijff, P. (author), Frants, R.R. (author), TNO Preventie en Gezondheid (author)

In a sample of Dutch families consisting of parents aged 35-65 years and their twin offspring aged 14-21 years, a significant difference between generations was observed in phenotypic variances and in genetic heritabilities for plasma levels of total cholesterol, triglycerides, high density lipoprotein (HDL) and low density lipoprotein (LDL)...

article 1996