Searched for: subject:"Validation%5C+process"
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Ramesh, S. (author), Nieuwenhof, R.J.C. (author), Seykens, X. (author), Srinivasan, S. (author), Sharma, G. (author)
SCR on Filter (SCRoF) is an efficient and compact NOX and PM reduction technology already used in series production for light-duty applications. The technology is now finding its way into the medium duty and heavy duty market. One of the key challenges for successful application is the robustness to real world variations. The solution to this...
conference paper 2016
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van der Voort, M.M. (author), van Wees, R.M.M. (author), Brouwer, S.D. (author), van der Jagt-Deutekom, M.J. (author), Verreault, J. (author)
Forensic analysis of explosions consists of determining the point of origin, the explosive substance involved, and the charge mass. Within the EU fP7 project Hyperion, TNO developed the Inverse Explosion Analysis (TNO-IEA) tool to estïmate the charge mass and point of origin based on observed damage around an explosion. In this paper inverse...
article 2015
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Souverein, O.W. (author), de Vries, J.H.M. (author), Freese, R. (author), Watzl, B. (author), Bub, A. (author), Miller III, E.R. (author), Castenmiller, J.J.M. (author), Pasman, W.J. (author), van het Hof, K. (author), Chopra, M. (author), Karlsen, A. (author), Dragsted, L.O. (author), Winkels, R. (author), Itsiopoulos, C. (author), Brazionis, L. (author), O'Dea, K. (author), van Loo-Bouwman, C.A. (author), Naber, T.H.J. (author), van der Voet, H. (author), Boshuizen, H.C. (author)
Fruit and vegetable consumption produces changes in several biomarkers in blood. The present study aimed to examine the dose-response curve between fruit and vegetable consumption and carotenoid (α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein and zeaxanthin), folate and vitamin C concentrations. Furthermore, a prediction model of...
article 2015
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Liang, W. (author), Menke, A.L. (author), Driessen, A. (author), Koek, G.H. (author), Lindeman, J.H. (author), Stoop, R. (author), Havekes, L.M. (author), Kleemann, R. (author), van den Hoek, A.M. (author)
Results: The criteria macrovesicular steatosis, microvesicular steatosis, hepatocellular hypertrophy, inflammation and fibrosis were generally applicable to rodent NAFLD. The inter-observer reproducibility (evaluated using the Intraclass Correlation Coefficient) between the ten observers was high for the analysis of macrovesicular steatosis and...
article 2014
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Berg, N. (author), de Wever, B. (author), Fuchs, H.W. (author), Gaca, M. (author), Krul, C.A.M. (author), Roggen, E.L. (author)
In November 2009 the In Vitro Testing Industrial Platform (IVTIP) organized a meeting entitled '. Toxicology in the 21st century - working our way towards a visionary reality'. Participating delegates included scientists, key opinion leaders, developers and users of 3Rs-related tests and testing strategies. This paper summarizes the discussions...
article 2011
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Coenen, P. (author), Kingma, I. (author), Boot, C.R.L. (author), Faber, G.S. (author), Xu, X. (author), Bongers, P.M. (author), van Dieën, J.H. (author)
This study aimed to develop, compare and validate two versions of a video analysis method for assessment of low back moments during occupational lifting tasks since for epidemiological studies and ergonomic practice relatively cheap and easily applicable methods to assess low back loads are needed. Ten healthy subjects participated in a protocol...
article 2011
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Manders, A.M.M. (author), Schaap, M. (author), Querol, X. (author), Albert, M.F.M.A. (author), Vercauteren, J. (author), Kuhlbusch, T.A.J. (author), Hoogerbrugge, R. (author), TNO Bouw en Ondergrond (author)
The oceans are a major source for particles that play an important role in many atmospheric processes. In Europe sea salt may contribute significantly to particulate matter concentrations. We have compiled sodium concentration data as a tracer for sea salt for 89 sites in Europe to provide more insight in the distribution of sea salt across...
article 2010
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Balvers, M.G.J. (author), Verhoeckx, K.C.M. (author), Witkamp, R.F. (author), TNO Kwaliteit van Leven (author)
A sensitive and specific LC-MS/MS method for the quantification of the endocannabinoids and related structures anandamide, 2-arachidonoyl glycerol, 2-arachidonyl glycerol ether, O-arachidonoyl ethanolamide, dihomo-γ-linolenoyl ethanolamide, docosatetraenoyl ethanolamide, N-arachidonoyl dopamine, N-arachidonyl glycine, N-oleoyl dopamine, oleoyl...
article 2009
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Hockley, S.L. (author), Mathijs, K. (author), Staal, Y.C.M. (author), Brewer, D. (author), Giddings, I. (author), van Delft, J.H.M. (author), Phillips, D.H. (author), TNO Kwaliteit van Leven (author)
Microarray technology is being used increasingly to study gene expression of biological systems on a large scale. Both interlaboratory and interplatform differences are known to contribute to variability in microarray data. In this study we have investigated data from different platforms and laboratories on the transcriptomic profile of HepG2...
article 2009
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de Boer, W.E.L. (author), Donceel, P. (author), Brage, S. (author), Rus, M. (author), Willems, J.H.B.M. (author), TNO Kwaliteit van Leven (author)
Background. Decisions on disability pensions are based, among others, on medical reports. The way these medical assessments are performed is largely unclear. The aim of the study was to determine which grounds are used by social insurance physicians (SIPs) in these assessments and to determine if the identification of these grounds can help...
article 2008
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Bottini, A.A. (author), Alepee, N. (author), Phillips, B. (author), Gribaldo, L. (author), de Silva, O. (author), Hartung, T. (author), Hendriksen, C. (author), Kuil, J. (author), Pazos, P. (author), Rhein, C. (author), Schiffelers, M.-J. (author), Stokes, W. (author), Theobald, A. (author), Vidal, J.-M. (author), van de Sandt, H. (author), Breier, S. (author), Sintes, J.R. (author), Blaauboer, B. (author), TNO Kwaliteit van Leven (author)
article 2008
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Tomaso, H. (author), Jacobs, D. (author), Eickhoff, M. (author), Scholz, H.C. (author), al Dahouk, S. (author), Kattar, M.M. (author), Reischl, U. (author), Plicka, H. (author), Strand Olsen, J. (author), Nikkari, S. (author), Matero, P. (author), Beuret, C. (author), Ciammaruconi, A. (author), Lista, F. (author), Gala, J.-L. (author), Broll, H. (author), Appel, B. (author), Sellek Cano, R.E. (author), Ybarra de Villavicencio, M.D.C. (author), Broekhuijsen, M.P. (author), Indra, A. (author), Petersen, R. (author), Neubauer, H. (author)
Background: Yersinia pestis (Y. pestis) is a zoonotic bacterium mainly circulating among rodents and their fleas. Transmission to humans can cause bubonic, pneumonic or septicemic plague with a high case-fatality rate. Therefore, rapid and reliable diagnostic tools are crucial. The objective of this study was to assess the inter-laboratory...
article 2008
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Fontaras, G. (author), Kouridis, H. (author), Samaras, Z. (author), Elst, D.A.M.M. (author), Gense, N.L.J. (author)
The reduction of CO2 emissions and fuel consumption from road transportation constitutes an important pillar of the EU commitment for implementing the Kyoto Protocol. Efforts to monitor and limit CO2 emissions from vehicles can effectively be supported by the use of vehicle modelling tools. This paper presents the application of such a tool for...
article 2007
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Oomes, S.J.C.M. (author), van Zuijlen, A.C.M. (author), Hehenkamp, J.O. (author), Witsenboer, H. (author), van der Vossen, J.M.B.M. (author), Brul, S. (author), TNO Kwaliteit van Leven (author)
Spore-forming bacteria can be a problem in the food industry, especially in the canning industry. Spores present in ingredients or present in the processing environment severely challenge the preservation process since their thermal resistance may be very high. We therefore asked the question which bacterial spore formers are found in a typical...
article 2007
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Vis, D.J. (author), Westerhuis, J.A. (author), Smilde, A.K. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
Background: Innovative extensions of (M) ANOVA gain common ground for the analysis of designed metabolomics experiments. ASCA is such a multivariate analysis method; it has successfully estimated effects in megavariate metabolomics data from biological experiments. However, rigorous statistical validation of megavariate effects is still...
article 2007
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Wilkinson, S.C. (author), Maas, W.J.M. (author), Nielsen, J.B. (author), Greaves, L.C. (author), van de Sandt, J.J.M. (author), Williams, F.M. (author), TNO Kwaliteit van Leven TNO Voeding (author)
Objectives: To determine the effect of skin thickness on the percutaneous penetration and distribution of test compounds with varying physicochemical properties using in vitro systems. Studies were carried out in accordance with OECD guidelines on skin absorption tests. Methods: Percutaneous penetration of caffeine (log P -0.01), testosterone ...
article 2006
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van den Berg, R.A. (author), Hoefsloot, H.C.J. (author), Westerhuis, J.A. (author), Smilde, A.K. (author), van der Werf, M.J. (author), TNO Kwaliteit van Leven (author)
Background: Extracting relevant biological information from large data sets is a major challenge in functional genomics research. Different aspects of the data hamper their biological interpretation. For instance, 5000-fold differences in concentration for different metabolites are present in a metabolomics data set, while these differences are...
article 2006
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Prinsen, M.K. (author), TNO Kwaliteit van Leven (author)
article 2006
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Cho, E. (author), Hunter, D.J. (author), Spiegelman, D. (author), Albanes, D. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Colditz, G.A. (author), Feskanich, D. (author), Folsom, A.R. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Miller, A.B. (author), Rohan, T.E. (author), Sellers, T.A. (author), Virtamo, J. (author), Willett, W.C. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)
Intakes of vitamins A, C and E and folate have been hypothesized to reduce lung cancer risk. We examined these associations in a pooled analysis of the primary data from 8 prospective studies from North America and Europe. Baseline vitamin intake was assessed using a validated food-frequency questionnaire, in each study. We calculated study...
article 2006
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Koushik, A. (author), Hunter, D.J. (author), Spiegelman, D. (author), Anderson, K.E. (author), Buring, J.E. (author), Freudenheim, J.L. (author), Goldbohm, R.A. (author), Hankinson, S.E. (author), Larsson, S.C. (author), Leitzmann, M. (author), Marshall, J.R. (author), McCullough, M.L. (author), Miller, A.B. (author), Rodriguez, C. (author), Rohan, T.E. (author), Ross, J.A. (author), Schatzkin, A. (author), Schouten, L.J. (author), Willett, W.C. (author), Wolk, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)
Carotenoids, found in fruits and vegetables, have the potential to protect against cancer because of their properties, including their functions as precursors to vitamin A and as antioxidants. We examined the associations between intakes of α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin and lycopene and the risk of invasive...
article 2006
Searched for: subject:"Validation%5C+process"
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