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van Dijk, K.W. (author), van Vlijmen, B.J.M. (author), de Winther, M.P.J. (author), van 't Hof, B. (author), van der Zee, A. (author), van der Boom, H. (author), Havekes, L.M. (author), Hofker, M.H. (author), Gaubius instituut TNO (author)To investigate the relative roles of the LDL receptor- and non-LDL receptor-mediated pathways in the clearance of apolipoprotein E (apoE) variants in vivo, we have generated apoE2(Arg158-Cys) (apoE2) and apoE3- Leiden transgenic mice deficient for the endogenous mouse Apoe and Ldl receptor genes (Apoe-/-.Ldlr-/- mice). Unexpectedly, on the Apoe-...article 1999
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TNO Preventie en Gezondheid (author), van Dijk, K.W. (author), van Vlijmen, B.J.M. (author), van 't Hof, H.B. (author), van der Zee, A. (author), Santamarina-Fojo, S. (author), van Berkel, T.J.C. (author), Havekes, L.M. (author), Hofker, M.H. (author)To investigate the quantitative requirement for apolipoprotein (apo) E in the clearance of lipoproteins via the non-low density lipoprotein (LDL) receptor mediated pathway, human APOE was overexpressed at various levels in the livers of mice deficient for both the endogenous Apoe and Ldlr genes (Apoe-/- ยท Ldlr-/-) using adenovirus-mediated gene...article 1999