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Jongen, V.W. (author), Schim van der Loeff, M.F. (author), Boyd, A. (author), Petrignani, M. (author), Prins, M. (author), van der Wal, M. (author), Nielen, A. (author), de Melker, H. (author), Pot, M. (author), Paulussen, T.G.W.M. (author), Alberts, C. (author)Introduction: It is unclear what role daughters play in the decision-making process regarding HPV vaccination. Therefore, we explored the impact of HPV vaccination intention among parents and their 12-13 year-old daughters on HPV vaccination uptake. Methods: In February 2014 parents/guardians and their 12-13 year-old daughters were invited to...article 2021
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Stevens, L.J. (author), Zhu, A.Z.X. (author), Chothe, P.P. (author), Chowdhury, S.K. (author), Donkers, J.M. (author), Vaes, W.H.J. (author), Knibbe, C.A.J. (author), Alwayn, I.P.J. (author), van de Steeg, E. (author)There is a lack of translational preclinical models that can predict hepatic handling of drugs. In this study we aimed to evaluate the applicability of normothermic machine perfusion (NMP) of porcine livers as a novel ex vivo model to predict hepatic clearance, biliary excretion and plasma exposure of drugs. For this evaluation we dosed...article 2021
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Gezici-Koc, Ö. (author), Erich, S.J.F. (author), Huinink, H.P. (author), van der Ven, L.G.J. (author), Adan, O.C.G. (author)In addition to the desired aesthetical properties, a coating is applied to protect against weathering. A coating prevents moisture accumulation in wood by reducing the water uptake into the wood by its barrier function. The studies in the coating permeability has gained interest with the shift towards waterborne coatings, which make coatings...article 2019
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Marra, E. (author), van Dam, L. (author), Kroone, N. (author), Alberts, C.J. (author), Craanen, M. (author), Zimet, G.D. (author), Heijmam, T. (author), Hogewoning, A.A. (author), Sonder, G.J.B. (author), de Vries, H.J.C. (author), Alberts, C.J. (author), Paulussen, T.G.W.M. (author), Schim van der Loeff, M.F. (author)Introduction: Female sex workers (FSWs) are at risk for human papillomavirus (HPV)-induced diseases but are currently not targeted by the HPV vaccination program in the Netherlands. We explored determinants of their intention to get vaccinated against HPV in case vaccination would be offered to them. Methods: In 2016, FSWs 18 years and older...article 2017
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van de Steeg, E. (author), Läppchen, T. (author), Aguilera, B. (author), Jansen, H.T. (author), Muilwijk, D. (author), Vermue, R. (author), van der Hoorn, J.W. (author), Donato, K. (author), Rossin, R. (author), de Visser, P.C. (author), Vlaming, M.L.H. (author)Antisense oligonucleotides (AONs) are promising candidates for treatment of Duchenne muscular dystrophy (DMD), a severe and progressive disease resulting in premature death. However, more knowledge on the pharmacokinetics of new AON drug candidates is desired for effective application in the clinic. We assessed the feasibility of using...article 2017
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Pot, M. (author), van Keulen, H.M. (author), Ruiter, R.A.C. (author), Eekhout, I. (author), Mollema, L. (author), Paulussen, T.W.G.M. (author)Background In the Netherlands, HPV-vaccination uptake among 12-year-old girls remains to be lower (61% in 2016) than expected. The present study is about 1) replicating the extent to which social-psychological determinants found in earlier cross-sectional studies explain HPV-vaccination intention, and 2) testing whether HPV-vaccination intention...article 2017
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Marra, E. (author), Alberts, C.J. (author), Zimet, G.D. (author), Paulussen, T.G.W.M. (author), Heijman, T. (author), Hogewoning, A.A. (author), Sonder, G.J.B. (author), Fennema, J.S. (author), de Vries, H.J.C. (author), Schim van der Loeff, M.F. (author)Background: Human papillomavirus (HPV) vaccination coverage in the Netherlands is low (~60%) compared to other childhood vaccinations (>90%), and even lower among ethnic minorities. The aim of this study was to explore the possible impact of ethnicity on the determinants of both HPV vaccination intention and HPV vaccination uptake among parents...article 2017
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Gezici-Koç, Ö. (author), Erich, S.J.F. (author), Huinink, H.P. (author), van der Ven, L.G.J. (author), Adan, O.C.G. (author)Knowledge on moisture transport in wood is important for understanding its utilization, durability and product quality. Moisture transport processes in wood can be studied by Nuclear Magnetic Resonance (NMR) imaging. By combining NMR imaging with relaxometry, the state of water within wood can be identified, i.e. water bound to the cell wall,...article 2017
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Gozalpour, E. (author), Greupink, R. (author), Wortelboer, H.M. (author), Bilos, A. (author), Schreurs, M. (author), Russel, F.G.M. (author), Koenderink, J.B. (author)Digitalis-like compounds (DLCs) such as digoxin, digitoxin, and ouabain, also known as cardiac glycosides, are among the oldest pharmacological treatments for heart failure. The compounds have a narrow therapeutic window, while at the same time, DLC pharmacokinetics is prone to drug-drug interactions at the transport level. Hepatic transporters...article 2014
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Donkers, P.A.J. (author), Huinink, H.P. (author), Erich, S.J.F. (author), Reuvers, N.J.W. (author), Adan, O.C.G. (author)Coatings are used in a variety of applications. Last decades more and more coating systems are transforming from solvent to waterborne coating systems. In this study the influence of pigments on the water permeability of a waterborne coating system is studied, with special interest in the possible interfacial layer of additives around the...article 2013
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Daanen, H.A.M. (author), Lamberts, R.P. (author), Kallen, V.L. (author), Jin, A. (author), Meeteren, N.L.U. (author)Heart-rate recovery (HRR) has been proposed as a marker of autonomic function and training status in athletes. The authors performed a systematic review of studies that examined HRR after training. Five cross-sectional studies and 8 studies investigating changes over time (longitudinal) met our criteria. Three out of 5 cross-sectional studies...article 2012
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Holtzer, A.C.G. (author), van der Giessen, A.M. (author), de Munck, S.G.E. (author), Poel, M.A. (author), Smets, R.C.J. (author)This deliverable describes the monitoring framework that will be used to monitor and evaluate the GEN6 project and its nine pilots. The main topics are IPv6 uptake and governance, as described by the EC. Monitoring and evaluation will be done during the course of the project. This report describes the monitoring framework, the monitoring...report 2012
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van Meel, P.A. (author), Erich, S.J.F. (author), Huinink, H.P. (author), Kopinga, K. (author), DE Jong, J. (author), Adan, O.C.G. (author)Moisture accumulation inside wood causes favorable conditions for decay. Application of a coating alters the moisture sorption of wood and prevents accumulation of moisture. This paper presents the results of a nuclear magnetic resonance (NMR) study on the influence of a coating on the moisture absorption of wood. NMR allows to determine both...article 2011
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van Bergen, F. (author), Spiers, C. (author), Floor, G. (author), Bots, P. (author), TNO Bouw en Ondergrond (author)Field experiments and laboratory studies have shown that swelling of coal takes place upon contact with carbon dioxide at underground pressure and temperature conditions. Understanding this swelling behavior is crucial for predicting the performance of future carbon dioxide sequestration operations in unminable coal seams conducted in...article 2009
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Wierckx, N. (author), Ruijssenaars, H.J. (author), de Winde, J.H. (author), Schmid, A. (author), Blank, L.M. (author), TNO Kwaliteit van Leven (author)The physiological effects of genetic and transcriptional changes observed in a phenol producing mutant of the solvent-tolerant Pseudomonas putida S12 were assessed with metabolic flux analysis. The upregulation of a malate/lactate dehydrogenase encoding gene could be connected to a flux increase from malate to oxaloacetate. A mutation in the...article 2009
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Vink, J.P.M. (author), TNO Bouw en Ondergrond (author)The speciation of heavy metals was measured over a variety of natural and undisturbed water/sediment interfaces. Simultaneously, two benthic species (oligochaete Limnodrilus spp. and the midge Chironomus riparius) were exposed to these sediments. Under occurring redox conditions, free ion activities of trace metals Cd, Cu, Ni, Pb, and Zn were...article 2009
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TNO Industrie en Techniek (author), Barbu, I. (author), Ivan, M.G. (author), Giesen, P.T.M. (author), van de Moosdijk, M. (author), Meinders, E.R. (author)Organic flexible electronics is an emerging technology with huge potential growth in the future which is likely to open up a complete new series of potential applications such as flexible OLED-based displays, urban commercial signage, and flexible electronic paper. The transistor is the fundamental building block of all these applications. A key...conference paper 2009
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Havenith, G. (author), TNO Defensie en Veiligheid (author)Data on metabolic rates (n = 0;81) and clothing insulation (n = 96) of school children and adolescents (A, primary school: age 9-10; B, primary school: age 10-11 year; C, junior vocational (technical) education: age 13-16 (lower level); D, same as C but at advanced level; and E, senior vocational (technical) education, advanced level: age 16-18)...article 2007
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Molag, M.L. (author), de Vries, J.H.M. (author), Ocké, M.C. (author), Dagnelie, P.C. (author), van den Brandt, P.A. (author), Jansen, M.C.J.F. (author), van Staveren, W.A. (author), van 't Veer, P. (author), TNO Kwaliteit van Leven (author)The authors investigated the role of food frequency questionnaire (FFQ) design, including length, use of portion-size questions, and FFQ origin, in ranking subjects according to their nutrient intake. They also studied the ability of the FFQ to detect differences in energy intake between subgroups and to assess energy and protein intake. In a...article 2007
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Wertheim, A.H. (author), Kemper, H.C.G. (author), Heus, R. (author)In previous studies on physical fatigue during simulated ship movements, the apparent exhaustion of subjects after experimentation suggested that the traditional index of physical workload, oxygen consumption expressed as the percentage of peak oxygen consumption (VO2-peak) measured in a separate graded exercise test (GXT), underestimates...article 2002
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