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Bayle, M.L. (author), Wopereis, S. (author), Bouwman, J. (author), van Ommen, B. (author), Scalbert, A. (author), Pujos-Guillot, E. (author)Recommended dietary allowances for micronutrients fluctuate noticeably within European Union countries. The Network of Excellence EURRECA (EURopean micronutrient RECommendations Aligned) aims at harmonising micronutrient intake recommendations through population groups. The lack of proper markers of status for some micronutrients limits progress...article 2012
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Coulier, L. (author), Gerritsen, H. (author), van Kampen, J.J.A. (author), Reedijk, M.L. (author), Luider, T.M. (author), Osterhaus, A.D.M.E. (author), Gruters, R.A. (author), Brüll, L. (author)Nucleoside reverse transcriptase inhibitors (NRTIs) are a key class of drugs for the treatment of HIV infection. NRTIs are intracellularly phosphorylated to their active triphosphate metabolites and compete with endogenous deoxynucleotides (dNTP) for substrate binding. It is therefore important to analyze the intracellular concentrations of...article 2011
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Hu, C. (author), Kong, H. (author), Zhu, C. (author), Wei, H. (author), Hankemeier, T. (author), van der Greef, J. (author), Wang, M. (author), Xu, G. (author)A method for fast analysis of ginsenosides in Panax ginseng roots was developed using ultra performance liquid chromatography-time-of-flight-mass spectrometry (UPLC-TOF-MS). The column used was HSS T3 (100 mm × 2.1 mm, 1.8 µm). The mobile phase consisted of 15 mmol/L ammonium formate and acetonitrile, eluted with the gradient program. The...article 2011
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Castro-Perez, J.M. (author), Kamphorst, J. (author), de Groot, J. (author), Lafeber, F. (author), Goshawk, J. (author), Yu, K. (author), Shockcor, J.P. (author), Vreeken, R.J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)A fast and robust method for lipid profiling utilizing liquid chromatography coupled with mass spectrometry has been demonstrated and validated for the analysis of human plasma. This method allowed quantification and identification of lipids in human plasma using parallel alternating low energy and high energy collision spectral acquisition...article 2010
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Wang, J. (author), Reijmers, T. (author), Chen, L. (author), van der Heijden, R. (author), Wang, M. (author), Peng, S. (author), Hankemeier, T. (author), Xu, G. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)A metabolomics-based systems toxicology approach was used to profile the urinary metabolites for the toxicity related processes and pathogenesis induced by doxorubicin (DOX) to rats. Endogenous metabolite profiles were obtained with ultra performance liquid chromatography-mass spectrometry (UPLC-MS) for rats receiving different single dosages of...article 2009