Searched for: subject:"Type%5C+2%5C+diabetes"
(1 - 18 of 18)
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Regeer, H. (author), Nieuwenhuijse, E.A. (author), Vos, R.C. (author), Kiefte-de Jong, J.C. (author), van Empelen, P. (author), de Koning, E.J.P. (author), Bilo, H.J.G. (author), Huisman, S.D. (author)
Aims: To investigate changes in physical activity (PA) and psychological factors during societal lockdown in people with type 2 diabetes. Methods: A cross-sectional study among Dutch adults with type 2 diabetes. Data were collected using online questionnaires. A multivariate multinomial logistic regression was performed with change in PA during...
article 2021
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Sluijs, T. (author), Lokkers, L. (author), Özsezen, S. (author), Veldhuis, G.A. (author), Wortelboer, H.M. (author)
The number of individuals suffering from type 2 diabetes is dramatically increasing worldwide, resulting in an increasing burden on society and rising healthcare costs. With increasing evidence supporting lifestyle intervention programs to reduce type 2 diabetes, and the use of scenario simulations for policy support, there is an opportunity to...
article 2021
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Regeer, H. (author), van Empelen, P. (author), Bilo, H.J.G. (author), de Koning, E.J.P. (author), Huisman, S.D. (author)
Objective. To examine the relationship between risk factors for low patient activation and change in patient activation, well-being, and health outcomes in people with type 2 diabetes mellitus (T2DM). Method. A longitudinal prospective study was conducted with measurements at baseline and 20-week follow-up among 603 people with T2DM...
article 2021
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Tans, R. (author), Verschuren, L. (author), Wessels, H.J.C.T. (author), Bakker, S.J.L. (author), Tack, C.J. (author), Gloerich, J. (author), van Gool, A.J. (author)
Introduction: The onset of type 2 diabetes mellitus (T2DM) is strongly associated with obesity and subsequent perturbations in immuno-metabolic responses. To understand the complexity of these systemic changes and better monitor the health status of people at risk, validated clinical biomarkers are needed. Omics technologies are increasingly...
article 2019
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van Ommen, B. (author), Wopereis, S. (author), van Empelen, P. (author), van Keulen, H.M. (author), Otten, W. (author), Kasteleyn, M. (author), Molema, J.J.W. (author), de Hoogh, I.M. (author), Chavannes, N.H. (author), Numans, M.E. (author), Evers, A.W.M. (author), Pijl, H. (author)
From a biological view, most of the processes involved in insulin resistance, which drives the pathobiology of type 2 diabetes, are reversible. This theoretically makes the disease reversible and curable by changing dietary habits and physical activity, particularly when adopted early in the disease process. Yet, this is not fully implemented...
article 2018
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van Stee, M.F. (author), de Graaf, A.A. (author), Groen, A.K. (author)
Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, both drugs act on glucose and lipid metabolism which could lead to adverse effects when used in combination as compared to monotherapy. In...
article 2018
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Sun, M. (author), van Wijk, E. (author), Koval, S. (author), van Wijk, R. (author), He, M. (author), Wang, M. (author), Hankemeier, T. (author), van der Greef, J. (author)
The global prevalence of type 2 diabetes is estimated to reach 4.4% by 2030, placing a significant burden on our healthcare system. Therefore, the ability to identify patients in early stages of the disease is essential for both prevention and effective management, and diagnostic methods based on traditional Chinese medicine (TCM) may be...
article 2017
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Wopereis, S. (author), Stroeve, J.H.M. (author), Stafleu, A. (author), Bakker, G.C.M. (author), Burggraaf, J. (author), van Erk, M.J. (author), Pellis, L. (author), Boessen, R. (author), Kardinaal, A.A.F. (author), van Ommen, B. (author)
Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultaneous quantification of major metabolic health processes. Currently, applied challenge tests are largely non-standardized. A...
article 2017
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Morrison, M.C. (author), Kleemann, R. (author)
Obesity is associated with a chronic low-grade inflammatory state that drives the -development of obesity-related co-morbidities such as insulin resistance/type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease. This metabolic inflammation is thought to originate in the adipose tissue, which becomes inflamed and...
article 2015
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Joosten, M.M. (author), Schrieks, I.C. (author), Hendriks, H.F.J. (author)
Background: Fetuin-A, a liver-derived glycoprotein that impairs insulin-signalling, has emerged as a biomarker for diabetes risk. Although moderate alcohol consumption has been inversely associated with fetuin-A, data from clinical trials are lacking. Thus, we evaluated whether moderate alcohol consumption decreases circulating levels of fetuin...
article 2014
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Stricker, M.D. (author), Hendriks, H.F.J. (author), Beulens, J.W.J. (author)
bookPart 2013
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Coomans, C.P. (author), Geerling, J.J. (author), van den Berg, S.A.A. (author), van Diepen, H.C. (author), Garcia-Tardõn, N. (author), Thomas, A. (author), Schröder-Van Der Elst, J.P. (author), Ouwens, D.M. (author), Pijl, H. (author), Rensen, P.C.N. (author), Havekes, L.M. (author), Guigas, B. (author), Romijn, J.A. (author)
Background and Purpose Topiramate improves insulin sensitivity, in addition to its antiepileptic action. However, the underlying mechanism is unknown. Therefore, the present study was aimed at investigating the mechanism of the insulin-sensitizing effect of topiramate both in vivo and in vitro. Experimental Approach Male C57Bl/6J mice were fed a...
article 2013
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Castiglione, F. (author), Tieri, P. (author), de Graaf, A.A. (author), Franceschi, C. (author), Liò, P. (author), van Ommen, B. (author), Mazzà, C. (author), Tuchel, A. (author), Bernaschi, M. (author), Samson, C. (author), Colombo, T. (author), Castellani, G.C. (author), Capri, M. (author), Garagnani, P. (author), Salvioli, S. (author), Nguyen, V.A. (author), Bobeldijk-Pastorova, I. (author), Krishnan, S. (author), Cappozzo, A. (author), Sacchetti, M. (author), Morettini, M. (author), Ernst, M. (author)
Background: Type 2 diabetes mellitus (T2D) is a common age-related disease, and is a major health concern, particularly in developed countries where the population is aging, including Europe. The multi-scale immune system simulator for the onset of type 2 diabetes (MISSION-T2D) is a European Union-funded project that aims to develop and validate...
article 2013
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van der Zijl, N.J. (author), Hanemaaijer, R. (author), Tushuizen, M.E. (author), Schindhelm, R.K. (author), Boerop, J. (author), Rustemeijer, C. (author), Bilo, H.J. (author), Verheijen, J.H. (author), Diamant, M. (author), TNO Kwaliteit van Leven (author)
Matrix metalloproteinases (MMPs) may play a pathophysiological role in the development of diabetic nephropathy (DN). We hypothesized that urinary MMP activity in patients with type 2 diabetes mellitus (T2DM) is related to a decline in renal function. We determined MMP-2, -8 and -9 activity in 24-h urine collections in relation to risk factors...
article 2010
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van den Hoek, A.M. (author), Teusink, B. (author), Voshol, P.J. (author), Havekes, L.M. (author), Romijn, J.A. (author), Pijl, H. (author), TNO Kwaliteit van Leven (author)
Obese humans are often insulin- and leptin resistant. Since leptin can affect glucose metabolism, it is conceivable that a lack of leptin signal transduction contributes to insulin resistance. It remains unclear whether leptin affects glucose metabolism via peripheral and/or central mechanistic routes. In the present study, we aimed: (i) to...
article 2008
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Spijkerman, A.M.W. (author), Gall, M.A. (author), Tarnow, L. (author), Twisk, J.W.R. (author), Lauritzen, E. (author), Lund-Andersen, H. (author), Emeis, J. (author), Parving, H.H. (author), Stehouwer, C.D.A. (author), TNO Kwaliteit van Leven (author)
Aims: To study whether microalbuminuria, endothelial dysfunction and low-grade inflammation are associated with the presence and progression of diabetic retinopathy. Methods: Patients with Type 2 diabetes (n = 328) attending a diabetes clinic were followed for 10 years and examined annually during the last 7 years. Retinopathy was assessed after...
article 2007
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van de Laar, F.A. (author), van de Lisdonk, E.H. (author), Lucassen, P.L.B.J. (author), Stafleu, A. (author), Mulder, J. (author), van den Hoogen, H.J.M. (author), Rutten, G.E.H.M. (author), van Weel, C. (author), TNO Kwaliteit van Leven (author)
Aims: To assess restrained, emotional and external eating behaviour in patients newly diagnosed with Type 2 diabetes compared with the general population, and to assess the relationship of eating behaviour to changes in fat and energy. Methods: We assessed emotional, external, and restrained eating behaviour and measured fat and energy intake in...
article 2006
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Manders, R.J. (author), Koopman, R. (author), Sluijsmans, W.E. (author), van den Berg, R. (author), Verbeek, K. (author), Saris, W.H. (author), Wagenmakers, A.J. (author), van Loon, L.J. (author), TNO Kwaliteit van Leven (author)
This study examined postprandial plasma insulin and glucose responses after co-ingestion of an insulinotropic protein (Pro) hydrolysate with and without additional free leucine with a single bolus of carbohydrate (Cho). Male patients with long-standing Type 2 diabetes (n = 10) and healthy controls (n = 10) participated in 3 trials in which...
article 2006
Searched for: subject:"Type%5C+2%5C+diabetes"
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