Searched for: subject:"Trichloroethylene"
(1 - 9 of 9)
document
Li, X. (author), Kjellander, B.K.C. (author), Anthony, J.E. (author), Bastiaansen, C.W.M. (author), Broer, D.J. (author), Gelinck, G.H. (author), TNO Industrie en Techniek (author)
Here, a new approach is introduced to prepare large single crystals of π-conjugated organic molecules from solution. Utilizing the concept of azeotropism, single crystals of tri-isopropylsilylethynyl pentacene (TIPS-PEN) with dimensions up to millimeters are facilely self-assembled from homogeneous solutions comprising two solvents with opposing...
article 2009
document
Hendriksen, P.J.M. (author), Freidig, A.P. (author), Jonker, D. (author), Thissen, U. (author), Bogaards, J.J.P. (author), Mumtaz, M.M. (author), Groten, J.P. (author), Stierum, R.H. (author), TNO Kwaliteit van Leven (author)
The present research aimed to study the interaction of three chemicals, methyl mercury, benzene and trichloroethylene, on mRNA expression alterations in rat liver and kidney measured by microarray analysis. These compounds were selected based on presumed different modes of action. The chemicals were administered daily for 14 days at the Lowest...
article 2007
document
Hissink, E.M. (author), Bogaards, J.J.P. (author), Freidig, A.P. (author), Commandeur, J.N.M. (author), Vermeulen, N.P.E. (author), van Bladeren, P.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
A physiologically based pharmacokinetic (PBPK) model has been developed for trichloroethylene (1,1,2-trichloroethene, TRI) for rat and humans, based on in vitro metabolic parameters. These were obtained using individual cytochrome P450 and glutathione S-transferase enzymes. The main enzymes involved both for rats and humans are CYP2E1 and the μ-...
article 2002
document
Vermeulen, N.P.E. (author), van Bladeren, P.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Interindividual variability in the disposition and effects of xenobiotics in humans and related inter-species differences should play a major role in human risk assessment. In particular for low-dose exposures to potentially carcinogenic compounds, novel tools and concepts are necessary to assess risks of chemical exposure, preferably based on...
article 2001
document
van Haelst, A.G. (author), Hansen, B.G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
One of the four steps within Council Regulation 793/93/EEC on the evaluation and control of existing chemicals is the priority setting step. The priority setting step is concerned with selecting high-priority substances from a large number of substances, initially starting with 2,474 high-production-volume chemicals. In order to be able to...
article 2000
document
Rijnaarts, H.H.M. (author), van Aalst-van Leeuwen, M.A. (author), van Heiningen, E. (author), van Buyzen, H. (author), Sinke, A. (author), van Liere, H.C. (author), Harkes, M. (author), Baartmans, R. (author), Bosma, T.N.P. (author), Doddema, H.J. (author), TNO Milieu, Energie en Procesinnovatie (author)
The feasibility of intrinsic and enhanced bioremediation approaches for 16 contaminated sites in the Netherlands are discussed. At at least five out of 10 chlorinated solvent sites, natural attenuation can be used as one of the tools to prevent further dispersion of the plume. At two sites stimulation of the intrinsic dechlorination processes in...
conference paper 1998
document
van Zutphen, M. (author), Heron, G. (author), Enfield, C.G. (author), Christensen, T.H. (author), Nederlands Instituut voor Toegepaste Geowetenschappen TNO (author)
A 2D-laboratory box experiment (12 x 56 x 116 cm) was conducted to simulate the enhancement of soil vapor extraction by the application of low frequency electrical heating Uoule heating) for the remediation of a low permeable, silty soil contaminated with trichloroethylene. Joule heating enlarged the flux of extracted TCE with a factor 19 (when...
conference paper 1998
document
Jonker, D. (author), Woutersen, R.A. (author), Feron, V.J. (author), TNO Voeding (author)
The toxicity of mixtures of chemicals with the same target organ was examined in rats using nephrotoxicants with similar or dissimilar modes of action. In a 4-wk feeding study, lysinoalanine, mercuric chloride, hexachloro-1,3-butadiene and d-limonene, each affecting renal proximal tubular cells but through different modes of action, were...
article 1996
document
Jaspers, R.M.A. (author), Muijser, H. (author), Lammers, J.H.C.M. (author), Kulig, B.M. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author)
Modification of auditory evoked startle responding using prepulse inhibition was used to examine the effects of trichloroethylene (TCE) exposure on auditory thresholds. Rats were exposed by inhalation to 0, 1500, or 3000 ppm TCE for 18 hours per day, 5 days a week for 3 weeks. Auditory thresholds for 5 and 20 kHz tones were measured before...
article 1993
Searched for: subject:"Trichloroethylene"
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