Searched for: subject%3A%22Triacylglycerol%255C%2Bblood%255C%2Blevel%22
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Gaubius Instituut TNO (author), Goudriaan, J.R. (author), Dahlmans, V.E.H. (author), Teusink, B. (author), Ouwens, D.M. (author), Febbraio, M. (author), Maassen, J.A. (author), Romijn, J.A. (author), Havekes, L.M. (author), Voshol, P.J. (author)
CD36 (fatty acid translocase) is involved in high-affinity peripheral fatty acid uptake. Mice lacking CD36 exhibit increased plasma free fatty acid and triglyceride (TG) levels and decreased glucose levels. Studies in spontaneous hypertensive rats lacking functional CD36 link CD36 to the insulin-resistance syndrome. To clarify the relationship...
article 2003
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Riese, H. (author), Houtman, I.L.D. (author), Doornen, L.J.P. (author), de Geus, E.J.C. (author)
This study examined the possible effects of job demands, decision latitude, and job-related social support on risk indicators for cardiovascular disease (CVD) in 165 female nurses. Job strain was measured with the Job Content Questionnaire; CVD risk was measured with insulin, total cholesterol, triglyceride (TG), high-density lipoprotein...
article 2000
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Schaafsma, G. (author), Meuling, W.J.A. (author), van Dokkum, W. (author), Bouley, C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: To investigate in adult male volunteers the effect of a new fermented milk product, fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids. Design: Randomized placebo-controlled double-blind two-way cross over trial with two treatment periods of three weeks, separated by a wash-out period of one...
article 1998
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Haverkate, F. (author), Thompson, S.G. (author), Pyke, S.D.M. (author), Gallimore, J.R. (author), Pepys, M.B. (author), TNO Preventie en Gezondheid (author)
Background. Inflammation is an important feature of atherosclerotic lesions, and increased production of the acute-phase reactant, C-reactive protein (CRP), is associated with a poor prognosis in severe unstable angina. We have investigated the existence and possible significance of the acute-phase responses of CRP and another sensitive reactant...
article 1997
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Kockx, M. (author), de Maat, M.P.M. (author), Knipscheer, H.C. (author), Kastelein, J.P. (author), Kluft, C. (author), Princen, H.M.G. (author), Kooistra, T. (author), Gaubius Instituut TNO (author)
Evaluation of fibrate treatment in humans has focused primarily on its anti-lipidaemic effects. A potentially favourable haemostasis-modulating activity of fibrates has also been recognized but the data are not consistent. We sought to learn more about this variability by examining the effects of gemfibrozil and ciprofibrate on plasma levels of...
article 1997
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Schuit, A.J. (author), Schouten, E.G. (author), Kluft, C. (author), de Maat, M. (author), Menheere, P.P.C.A. (author), Kok, F.J. (author), Gaubius Instituut TNO (author)
The elevated incidence of thrombotic disease in elderly people may be associated with an increase in PAI-1 and fibrinogen with ageing. Cross-sectional studies report an inverse relation of PAI-1 and fibrinogen with physical activity, but training studies show inconsistent results. In a controlled intervention study among elderly subjects (aged...
article 1997
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Mennen, L.I. (author), de Maat, M.P.M. (author), Schouten, E.G. (author), Kluft, C. (author), de Jong, P.T.V.M. (author), Hofman, A. (author), Grobbee, D.E. (author), Gaubius Instituut TNO (author)
Coagulation factor VII activity (FVII:C) is a risk indicator for cardiovascular disease. It is related to serum-triglycerides and the R/Q353 polymorphism (alleles R and Q) in the gene coding for factor VII is strongly associated with factor VU[. The association of serum-triglycerides with factor VII may differ between the genotypes, but the...
article 1997
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Jong, M.C. (author), Dahlmans, V.E.H. (author), van Gorp, P.J.J. (author), Breuer, M.L. (author), Mol, M.J.T.M. (author), van der Zee, A. (author), Frants, R.R. (author), Hofker, M.H. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
Transgenic mice overexpressing human APOE*3Leiden are highly susceptible to diet-induced hyperlipoproteinemia and atherosclerosis due to a defect in hepatic uptake of remnant lipoproteins. In addition to the human APOE*3Leiden gene, these mice carry the human APOC1 gene (APOE*3Leiden- C1). To investigate the possible effect of simultaneous...
article 1996
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van Ree, J.H. (author), Hofker, M.H. (author), van den Broek, J.A.A. (author), van Deursen, J.M.A. (author), van der Boom, H. (author), Frants, R.R. (author), Wieringa, B. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
The function of apolipoprotein (apo) C1 in vivo is not well understood. From in vitro studies it has been reported that an excess of apoC1 relative to apoE inhibits receptor-mediated uptake of remnant lipoproteins. In order to gain a better understanding of the role of apoC1 in lipoprotein metabolism in vivo, we have generated apoC1-deficient...
article 1995
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