- document
-
van Gool, A.J. (author), Bietrix, F. (author), Caldenhoven, E. (author), Zatloukal, K. (author), Scherer, A. (author), Litton, J.E. (author), Meijer, G. (author), Blomberg, N. (author), Smith, A. (author), Mons, B. (author), Heringa, J. (author), Koot, W.J. (author), Smit, M.J. (author), Hajduch, M. (author), Rijnders, T. (author), Ussi, A. (author)[No abstract available] Chemicals / CAS Biomarkers.article 2017
- document
-
Mihaescu, R. (author), Detmar, S.B. (author), Cornel, M.C. (author), van der Flier, W.M. (author), Heutink, P. (author), Hol, E.M. (author), Rikkert, M.G.M.O. (author), van Duijn, C.M. (author), Janssens, A.C.J.W. (author), TNO Kwaliteit van leven (author)Alzheimer's disease (AD) is the most prevalent form of dementia and the number of cases is expected to increase exponentially worldwide. Three highly penetrant genes (AβPP, PSEN1, and PSEN2) explain only a small number of AD cases with a Mendelian transmission pattern. Many genes have been analyzed for association with non-Mendelian AD, but the...article 2010
- document
-
TNO Kwaliteit van Leven (author), Gaisser, S. (author), Vignola-Gagné, E. (author), Hüsing, B. (author), Enzing, C. (author), van der Valk, T. (author)Against the background of a number of first drug-diagnostic co-products developed and introduce into the European market, European decision-makers feel impelled to react and position themselves in the field of personalized medicine. Their reactions cover a broad range, from the analysis of knowledge requirements for market approval to the need...article 2009
- document
-
Damian, D. (author), Orešič, M. (author), Verheij, E. (author), Meulman, J. (author), Friedman, J. (author), Adourian, A. (author), Morel, N. (author), Smilde, A. (author), Greef, J. (author), TNO Kwaliteit van Leven (author)A novel clustering approach named Clustering Objects on Subsets of Attributes (COSA) has been proposed (Friedman and Meulman, (2004). Clustering objects on subsets of attributes. J. R. Statist. Soc. B 66, 1-25.) for unsupervised analysis of complex data sets. We demonstrate its usefulness in medical systems biology studies. Examples of...article 2007