Searched for: subject%3A%22Trachea%22
(1 - 17 of 17)
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Koivisto, A.J. (author), Kling, K.I. (author), Fonseca, A.S. (author), Brostrøm Bluhme, A. (author), Moreman, M. (author), Yu, M. (author), Costa, A.L. (author), Giovanni, B. (author), Ortelli, S. (author), Fransman, W. (author), Vogel, U. (author), Jensen, K.A. (author)
Nanoscale TiO2 (nTiO2) is manufactured in high volumes and is of potential concern in occupational health. Here, we measured workers exposure levels while ceramic honeycombs were dip coated with liquid photoactive nanoparticle suspension and dried with an air blade. The measured nTiO2 concentration levels were used to assess process specific...
article 2018
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Rusch, G.M. (author), Bowden, A.M. (author), Muijser, H. (author), Arts, J. (author), TNO Kwaliteit van Leven (author)
The objectives of this study were to examine the respiratory irritancy of boron trifluoride (BF3) and fluorosulfonic acid (FSA) following acute inhalation exposure. Testing was conducted using groups of 10 male and 10 female rats (BF3) or groups of 6 male rats (FSA). Rats were exposed for a single 4-h period (BF3) or a single 1-h period (FSA)...
article 2008
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Arts, J.H.E. (author), de Koning, M.W. (author), Bloksma, N. (author), Kuper, C.F. (author), TNO Voeding (author)
The present study investigated whether airway responses of sensitized rats to trimellitic anhydride (TMA) were concentration dependent and whether these were related to irritation by TMA. Groups of BN and Wistar rats were sensitized by two dermal applications of TMA (50% w/v, followed by 25% w/v in vehicle). Controls received vehicle (acetone...
article 2004
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van Helden, H.P.M. (author), Kuijpers, W.C. (author), Diemel, R.V. (author)
The purpose of the present study was to investigate: (1) the acute effects of sulfur mustard on airway, lung, and surface tension of bronchoalveolar lavage fluid (BALfluid) in guinea pigs following intratracheal (i.t.) exposure to 1LD50 of an aerosolized solution of sulfur mustard in saline, and (2) the therapeutic efficacy of i.t....
article 2004
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van Rozendaal, B.A.W.M. (author), van de Lest, C.H.A. (author), van Eijk, M. (author), van Golde, L.M.G. (author), Voorhout, W.F. (author), van Helden, H.P.M. (author), Haagsman, H.P. (author)
Collectins are carbohydrate binding proteins that are implicated in innate host defense. The lung collectins, surfactant proteins A and D (SP-A and SP-D), bind a variety of pathogens in vitro and influence phagocytosis by alveolar macrophages. In this report we show that SP-D binds endotoxin (lipopolysaccharide, LPS) in vivo in a rat model of...
article 1999
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Wolterbeek, A.P.M. (author), Ciotti, M.A.L.T. (author), Schoevers, E.J. (author), Roggeband, R. (author), Baan, R.A. (author), Feron, V.J. (author), Rutten, A.A.J.J.L. (author), TNO Voeding (author)
Tracheal organ cultures and isolated tracheal epithelial cells are frequently used to study effects of carcinogens and retinoids on both proliferation and differentiation of respiratory tract epithelial cells. For each of these in vitro models, optimal culture conditions have been established, varying in type of culture medium and composition of...
article 1996
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Wolterbeek, A.P.M. (author), Ciotti, M.A.L.T. (author), Schoevers, E.J. (author), Feron, V.J. (author), Rutten, A.A.J.J.L. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Chemicals/CAS: benzo[a]pyrene, 50-32-8; calcium ion, 14127-61-8; retinol, 68-26-8, 82445-97-4
article 1996
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Wolterbeek, A.P.M. (author), Roggeband, R. (author), Baan, R.A. (author), Feron, V.J. (author), Rutten, A.A.J.J.L. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Vitamin A and β-carotene protect against respiratory tract cancer by inhibiting the formation of DNA damage and controlling cellular proliferation and differentiation, Recently, it has been shown that the p53 tumor-suppressor gene plays a crucial role in the etiology of respiratory tract cancer. In the present study, we investigated the...
article 1995
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Wolterbeek, A.P.M. (author), Roggeband, R. (author), van Moorsel, C.J.A. (author), Baan, R.A. (author), Koeman, J.H. (author), Feron, V.J. (author), Rutten, A.A.J.J.L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Although most studies concerning the effect of vitamin A and β-carotene on chemical carcinogenesis are focused on tumour promotion and progression, these compounds may affect initiation as well. In this study the influence of vitamin A and β-carotene on unscheduled DNA synthesis (UDS) was investigated in hamster tracheal epithelium in organ...
article 1995
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Instituut CIVO-Toxicologie en Voeding TNO (author), Bogaards, J.J.P. (author), van Ommen, B. (author), van Bladeren, P.J. (author)
Eight dimeric isoenzymes of glutathione S-transferase (GST) were purified from liver, kidney and testis of the Syrian golden hamster, using S-hexylglutathione affinity chromatography and chromatofocusing. The isoenzymes were characterized according to their substrate selectivity, physical properties and amino acid sequence analysis. Thus a...
article 1992
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Rutten, A.A.J.J.L. (author), Wilmer, J.W.G.M. (author), Beems, R.B. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The effects of cigarette smoke condensate (CSC) and all-trans retinol on the cell proliferative activity of vitamin A-deprived hamster tracheal epithelium have been studied in vitamin A-deficient, serum-free, hormone-supplemented medium in organ culture. In the absence of retinol, CSC induced a dose-dependent increase in labelig index (LI)...
article 1988
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Rutten, A.A.J.J.L. (author), Beems, R.B. (author), Wilmer, J.W.G.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The effects of all-trans retinol and cigarette smoke condensate (CSC) on tissue morphology and cellular differentiation were investigated in vitamin A-deprived tracheal epithelium cultured in vitamin A- and serum-free hormone-supplemented medium. Physiological retinol concentrations prevented the development of hyperplasia and squamous...
article 1988
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Rutten, A.A.J.J.L. (author), Jongen, W.M.F. (author), de Haan, L.H.J. (author), Hendriksen, E.G.J. (author), Koeman, J.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The dye-coupled intercellular communication across gap junctions in primary hamster tracheal epithelial cells has been studied in serum-free, hormone-supplemented medium. In the absence of vitamin A, non-cytotoxic concentrations of cigarette-smoke condensate (CSC) inhibited intercellular communication between tracheal epithelial cells in a...
article 1988
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Reynders, J.B.J. (author), Immel, H.R. (author), Scherrenberg, P.M. (author), Feron, V.J. (author), Beems, R.B. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Two groups of male and female Syrian golden hamsters, of which the trachea was severely injured by electrocoagulation, received 6 weekly intratracheal instillations of benzo[a]pyrene (BaP) + ferric oxide in saline or saline alone. Two comparable groups of hamsters were similarly treated but had an undamaged trachea. The experiment was terminated...
article 1985
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Feron, V.J. (author), Immel, H.R. (author), Spit, B.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
The trachea of Syrian golden hamsters was injured by electrocoagulation. The lesions induced as well as the repair process were studied by light and scanning electron microscopy. The changes observed were considered to create the proper conditions for studying the significance of severe focal damage to the respiratory tract for the formation of...
article 1984
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Instituut CIVO-Toxicologie en Voeding TNO (author), Reuzel, P.G.J. (author), Immel, H.R. (author), Spit, B.J. (author), Feron, V.J. (author)
article 1984
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Reuzel, P.G.J. (author), Feron, V.J. (author), Spit, B.J. (author), Beems, R.B. (author), Kroes, R. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Cofactors involved in respiratory tract carcinogenesis were studied in Syrian golden hamster or in rats using benzo(a)pyrene as the carcinogenic agent. These factors included severe tissue tissue damage induced by electro-coagulation, glass fibers administered by intratracheal instillation, acetaldehyde as irritant vapor, food restriction, and...
article 1983
Searched for: subject%3A%22Trachea%22
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